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"Changwoo Kang"

Original Articles

Toxicology

Therapeutic effect of ascorbic acid on dapsone-induced methemoglobinemia in rats
Changwoo Kang, Dong Hoon Kim, Taeyun Kim, Soo Hoon Lee, Jin Hee Jeong, Sang Bong Lee, Jin Hyun Kim, Myeong Hee Jung, Kyung-woo Lee, In Sung Park
Clin Exp Emerg Med 2018;5(3):192-198.   Published online September 30, 2018
DOI: https://doi.org/10.15441/ceem.17.253

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Therapeutic effect of ascorbic acid on dapsone-induced methemoglobinemia in rats
Clin Exp Emerg Med. 2018;5(3):192-198.   Published online September 30, 2018
DOI: https://doi.org/10.15441/ceem.17.253
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Therapeutic effect of ascorbic acid on dapsone-induced methemoglobinemia in rats
Clin Exp Emerg Med. 2018;5(3):192-198.   Published online September 30, 2018
DOI: https://doi.org/10.15441/ceem.17.253
Close
Objective
Dapsone (diaminodiphenyl sulfone, DDS) is currently used to treat leprosy, malaria, dermatitis herpetiformis, and other diseases. It is also used to treat pneumocystis pneumonia and Toxoplasma gondii infection in HIV-positive patients. The most common adverse effect of DDS is methemoglobinemia from oxidative stress. Ascorbic acid is an antioxidant and reducing agent that scavenges the free radicals produced by oxidative stress. The present study aimed to investigate the effect of ascorbic acid in the treatment of DDS induced methemoglobinemia.
Methods
Male Sprague-Dawley rats were divided into three groups: an ascorbic acid group, a methylene blue (MB) group, and a control group. After DDS (40 mg/kg) treatment via oral gavage, ascorbic acid (15 mg/kg), MB (1 mg/kg), or normal saline were administered via tail vein injection. Depending on the duration of the DDS treatment, blood methemoglobin levels, as well as the nitric oxide levels and catalase activity, were measured at 60, 120, or 180 minutes after DDS administration.
Results
Methemoglobin concentrations in the ascorbic acid and MB groups were significantly lower compared to those in the control group across multiple time points. The plasma nitric oxide levels and catalase activity were not different among the groups or time points.
Conclusion
Intravenous ascorbic acid administration is effective in treating DDS-induced methemoglobinemia in a murine model.

Citations

Citations to this article as recorded by  Crossref logo
  • Congenital methaemoglobinaemia in pregnancy
    Anusha Tamma Reddy, Manisha Madhai Beck, Greeshma Grace Thomas, Nitish Vijayanand
    BMJ Case Reports.2025; 18(5): e263737.     CrossRef
  • Alpha-Lipoic Acid Reduces Methemoglobin and Oxidative Imbalance in the Blood and Liver Induced by Dapsone in Mice: Molecular Mechanism of Antioxidant Action
    Savio Monteiro dos Santos, Joni Tetsuo Sakai, Bruno Alexandre Quadros Gomes, Lisa Maria Mendes de Almeida Souza, Roseane Guimarães Ferreira, Kaio Murilo Monteiro Espíndola, Ana Flávia Oliveira Pampolha, Kelly Davis, Pamela Suelen da S. Seabra, Larissa de
    ACS Pharmacology & Translational Science.2025; 8(7): 2153.     CrossRef
  • Ascorbic Acid for Methemoglobinemia Treatment: A Case Report and Literature Review
    Kelli R Keats, Rachel Robinson, Mallika Patel, Alexis Wallace, Stephanie Albrecht
    Journal of Pharmacy Practice.2024; 37(4): 1015.     CrossRef
  • The Potential Effect of Dapsone on the Inflammatory Reactions in COVID-19: Staggering View
    Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Engy Elekhnawy, Athanasios Alexiou, Gaber El-Saber Batiha
    Combinatorial Chemistry & High Throughput Screening.2024; 27(5): 674.     CrossRef
  • Free Radical Scavenging Activity of Boron and Vitamin C in Nitrite-Induced Hemoglobin Oxidation Model: In vitro and in vivo Studies
    Hozan Jaza Hama Salh, Tavga Ahmed Aziz, Zheen Aorahman Ahmed, Dlivan Fattah Aziz
    Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ).2023; 5: 157.     CrossRef
  • Hemolytic anemia in COVID-19
    Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Ajeet Kaushik, Małgorzata Kujawska, Gaber El-Saber Batiha
    Annals of Hematology.2022; 101(9): 1887.     CrossRef
  • Methaemoglobinaemia in pregnancy: Real world experience in a single centre in Malaysia
    Andy Sing Ong Tang, Kok Choon Cheah, Tze Shin Leong, Lee Ping Chew
    Proceedings of Singapore Healthcare.2022;[Epub]     CrossRef
  • Rapid Potentiometric Determination of Ascorbic Acid Using Iodate as a Reagent
    Anita Martinović Bevanda, Antonela Matić, Stanislava Talić, Anita Ivanković, Ante Prkić, Andrea Paut, Tina Vukušić
    International Journal of Electrochemical Science.2022; 17(7): 220730.     CrossRef
  • Methemoglobinemia due to prilocaine use during jaw deformity surgery: A case report
    Naoko Tsunoda, Tadashi Kawai, Kei Onodera, Yuko Komatsu, Shuu Suzuki, Toshimi Chiba, Hiroyuki Yamada
    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2020; 32(5): 377.     CrossRef
  • Role of ascorbic acid in dapsone induced methemoglobinemia
    Kamal Kant Sahu, Ajay Kumar Mishra
    Clinical and Experimental Emergency Medicine.2019; 6(1): 91.     CrossRef
  • Methemoglobinemia: Infants at risk
    Sarah Fossen Johnson
    Current Problems in Pediatric and Adolescent Health Care.2019; 49(3): 57.     CrossRef
  • 19,139 View
  • 196 Download
  • 13 Web of Science
  • 11 Crossref

Imaging

Change in guardians’ preference for computed tomography after explanation by emergency physicians in pediatric head injury
Jin Hee Jeong, Jin Hee Lee, Kyuseok Kim, Joong Eui Rhee, Tae Yun Kim, You Hwan Jo, Yu Jin Kim, Jae Hyuk Lee, Changwoo Kang, Soo Hoon Lee, Joonghee Kim, Chan Jong Park, Hyuksool Kwon
Clin Exp Emerg Med 2015;2(4):226-235.   Published online December 28, 2015
DOI: https://doi.org/10.15441/ceem.14.039

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Change in guardians’ preference for computed tomography after explanation by emergency physicians in pediatric head injury
Clin Exp Emerg Med. 2015;2(4):226-235.   Published online December 28, 2015
DOI: https://doi.org/10.15441/ceem.14.039
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Change in guardians’ preference for computed tomography after explanation by emergency physicians in pediatric head injury
Clin Exp Emerg Med. 2015;2(4):226-235.   Published online December 28, 2015
DOI: https://doi.org/10.15441/ceem.14.039
Close
Objective
Head injury in children is a common problem presenting to emergency departments, and cranial computed tomography scanning is the diagnostic standard for these patients. Several decision rules are used to determine whether computed tomography scans should be used; however, the use of computed tomography scans is often influenced by guardians’ preference toward the scans. The objective of this study was to identify changes in guardian preference for minor head injuries after receiving an explanation based on the institutional clinical practice guideline.
Methods
A survey was conducted between July 2010 and June 2012. Patients younger than 16 years with a Glasgow Coma Scale score of 15 after a head injury and their guardians were included. Pre- and post-explanation questionnaires were given to guardians to assess their preference for computed tomography scans and factors related to the degree of preference. Treating physicians explained the risks and benefits of cranial computed tomography scanning using the institutional clinical practice guideline. Guardian preference for a computed tomography scan was examined using a 100-mm visual analog scale.
Results
In total, 208 patients and their guardians were included in this survey. Guardian preference for computed tomography scans was significantly reduced after explanation (46.7 vs. 17.4, P<0.01). Pre-explanation preference and the strength of the physician recommendation to get a computed tomography were the most important factors affecting pre- and post-explanation changes in preferences.
Conclusion
Explanation of the risks and benefits of cranial computed tomography scans using the institutional clinical practice guideline may significantly reduce guardian preference for computed tomography scans.

Citations

Citations to this article as recorded by  Crossref logo
  • Optimizing Advanced Imaging of the Pediatric Patient in the Emergency Department: Technical Report
    Jennifer R. Marin, Todd W. Lyons, Ilene Claudius, Mary E. Fallat, Michael Aquino, Timothy Ruttan, Reza J. Daugherty
    Journal of the American College of Radiology.2024; 21(7): e37.     CrossRef
  • Optimizing Advanced Imaging of the Pediatric Patient in the Emergency Department: Technical Report
    Jennifer R. Marin, Todd W. Lyons, Ilene Claudius, Mary E. Fallat, Michael Aquino, Timothy Ruttan, Reza J. Daugherty, Gregory P. Conners, Sylvia Owusu-Ansah, Kerry S. Caperell, Jennifer Hoffmann, Benson Hsu, Deborah Hsu, Jennifer E. McCain, Mohsen Saidinej
    Pediatrics.2024;[Epub]     CrossRef
  • Risk stratification of intermediate-risk children with minor head injury: a secondary publication translated into Korean
    Jung Heon Kim
    Pediatric Emergency Medicine Journal.2022; 9(1): 1.     CrossRef
  • Clinical Decision Rule to Identify Orbital Wall Fracture Among Children
    So Hyun Paek, Jin Hee Jung, Young Ho Kwak, Do Kyun Kim, Jin Hee Lee, Jae Yun Jung, Sohee Oh
    Pediatric Emergency Care.2020; 36(5): e280.     CrossRef
  • Risk Stratification of Intermediate-Risk Children With Minor Head Injury
    Yura Ko, Ji Sook Lee, Minjung Kathy Chae, Jung Hwan Ahn, Hyuk-Hoon Kim, Eun Jung Park, Jung Heon Kim
    Pediatric Emergency Care.2020; 36(11): e659.     CrossRef
  • Is cranial computed tomography unnecessary in children with a head injury and isolated vomiting?
    Simon Hardman, Ola Rominiyi, David King, Edward Snelson
    BMJ.2019; : l1875.     CrossRef
  • 10,699 View
  • 117 Download
  • 4 Web of Science
  • 6 Crossref
Perception of radiation dose and potential risks of computed tomography in emergency department medical personnel
Jin Hee Lee, Kyuseok Kim, Kyoung Ho Lee, Kwang Pyo Kim, Yu Jin Kim, Chanjong Park, Changwoo Kang, Soo Hoon Lee, Jin Hee Jeong, Joong Eui Rhee
Clin Exp Emerg Med 2015;2(2):123-129.   Published online June 30, 2015
DOI: https://doi.org/10.15441/ceem.14.019

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Perception of radiation dose and potential risks of computed tomography in emergency department medical personnel
Clin Exp Emerg Med. 2015;2(2):123-129.   Published online June 30, 2015
DOI: https://doi.org/10.15441/ceem.14.019
Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
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Perception of radiation dose and potential risks of computed tomography in emergency department medical personnel
Clin Exp Emerg Med. 2015;2(2):123-129.   Published online June 30, 2015
DOI: https://doi.org/10.15441/ceem.14.019
Close
Objective
The overall use of Computed Tomography (CT) continues to grow inside the hospital. Despite CT imaging is a valuable diagnostic technique, the relatively high radiation doses associated with CT compared with conventional radiography have raised health concerns such as future cancer risk. We investigated the awareness level concerning radiation dose and possible risks associated with CT scans in medical personnel (MP).
Methods
and materials: This study was conducted from April to May 2012. Physicians and nurses who worked in emergency department of 17 training hospitals were enrolled in the survey. The questionnaire included the degree of CT scan or radiography affecting health using a 10 numerical rating scale, estimation of the radiation dose for the CT scan compared with one chest radiograph, and the perception of the increased lifetime cancer risk of CT scan.
Results
A total of 354 MP participated in this study. They included 142 nurses, 87 interns, 86 residents, and 39 specialists. Interns were less aware of CT scan or radiography affecting health than other physicians or nurses (4.8±2.7 vs. 5.9±2.7 vs. 6.1±2.7 vs. 6.0±2.2, interns vs. residents vs. faculties vs. nurses, respectively. mean (SD). p < 0.05). There was significant difference in the knowledge about the relative radiation dose of the CT scan for one chest radiograph between doctors and nurses (48.6% vs. 28.9%, doctors vs. nurses, p < 0.05). MPs perceived increased cancer risk from radiation of CT scan.
Conclusions
Medical personnels perceived the radiation risk associated with CT scan, but seems to be insufficient.

Citations

Citations to this article as recorded by  Crossref logo
  • A Flowchart to Guide Emergency Physicians to Order Radiological Imaging in Pregnant Patients: Findings from an Emergency Department Questionnaire
    Fatih Cemal Tekin, Abdullah Enes Ataş, Fulya Köse, Demet Acar
    Healthcare.2025; 13(23): 3138.     CrossRef
  • Establishment of CT diagnostic reference levels (DRLs) for a Singapore healthcare cluster
    L. Arlany, H.G. Toh, B. Nazir, J.J. Ng, Y.H. Tay, Y.S. Tay, C.J.X. Poon, L.N. Lee, W.K.S. Fum, E.Y.T. Lee, S.I. Mariah, M.V. Fortier, W.P. Tham, L.L. Chew, K.H.E. Chong, L.R. Chong
    Radiography.2023; 29(1): 184.     CrossRef
  • Do physicians counsel patients regarding radiation risks of CT?: A survey of emergency department patients
    Elizabeth Sullivan, Brook Danboise, Kaitlin Hunt, Mary Hamblen, Michael Simmons, Shreya Kumar, Peter Richman
    The American Journal of Emergency Medicine.2023; 71: 233.     CrossRef
  • Strategies for Dose Optimization: Views From Health Care Systems
    Robin R. Whitebird, Leif I. Solberg, Philip W. Chu, Rebecca Smith-Bindman
    Journal of the American College of Radiology.2022; 19(4): 534.     CrossRef
  • Patients’ perception of radiation safety of radiological investigations in urology
    Prakrit R Kumar, Stuart Irving
    Journal of Clinical Urology.2021; 14(6): 475.     CrossRef
  • 13,861 View
  • 102 Download
  • 7 Web of Science
  • 5 Crossref

Critical Care

Awareness and knowledge of sepsis in the general Korean population: comparison with the awareness and knowledge of acute myocardial infarction and stroke
Minji Park, Kyuseok Kim, Jae Hyuk Lee, Changwoo Kang, You Hwan Jo, Dong Hoon Kim, Kyeong Won Kang, Soo Hoon Lee, Chanjong Park, Joonghee Kim, Heajin Chung, Hyunmi Park, Sujin Jang
Clin Exp Emerg Med 2014;1(1):41-48.   Published online September 30, 2014
DOI: https://doi.org/10.15441/ceem.14.014

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Awareness and knowledge of sepsis in the general Korean population: comparison with the awareness and knowledge of acute myocardial infarction and stroke
Clin Exp Emerg Med. 2014;1(1):41-48.   Published online September 30, 2014
DOI: https://doi.org/10.15441/ceem.14.014
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Awareness and knowledge of sepsis in the general Korean population: comparison with the awareness and knowledge of acute myocardial infarction and stroke
Clin Exp Emerg Med. 2014;1(1):41-48.   Published online September 30, 2014
DOI: https://doi.org/10.15441/ceem.14.014
Close
Objective

Patients with severe sepsis or septic shock require timely, aggressive management to improve their outcomes, and early presentation of patients to the hospital may also be important. Thus, public awareness about sepsis may be important for improved outcomes. However, there are no studies regarding the public awareness of sepsis in the general Korean population. Therefore, the objective of this survey was to gain insight into the public awareness of sepsis.

 Methods

Prospective paper-based and web-based surveys were issued between May and June 2013 to adults aged ≥18 years.

 Results

A total of 1,081 participants responded to the survey (394 paper-based and 687 web-based). Mean age was 38.7±11.4 years, and 541 participants (50%) were men. Of the 1,081 participants, 831 (76.9%) had heard of the term “sepsis.” Of these participants, only 295 (35%) responded correctly regarding the definition of sepsis. However, 1,019 participants (94.3%) had heard of acute myocardial infarction, and 817 of these (80%) correctly defined acute myocardial infarction. Regarding stroke, 1,047 (96.9%) had heard of stroke, and 975 of these responded (93.1%) correctly to the definition of stroke.

 Conclusion

There is poor public awareness about sepsis compared with that of acute myocardial infarction and stroke. This may limit the timely management of severe sepsis and septic shock.

Citations

Citations to this article as recorded by  Crossref logo
  • The Role of Perceived Urgency and Barriers in Using Emergency Medical Care for Sepsis: A German-Wide, Representative Survey Using Case Vignettes
    Sebastian Born, Norman Rose, Silke Piedmont, Daniel Schwarzkopf, Mathias W. Pletz, Wiltrud Abels, Konrad Reinhart, Carolin Fleischmann-Struzek
    Critical Care Medicine.2026; 54(2): 291.     CrossRef
  • Public knoweldge of sepsis in Saudi Arabia: A cross-sectional study
    Kadejh Abdulrahman Bashekah, Alla Hussain Felemban, Lubna Abdulrahman Hafiz, Abdulrahman Mauafaq Aljifri, Dalal Nasser Gaith Alsharif, Abdulaziz Ahmad Albarakati, Hind Mauafaq Aljifri, Sarah Mauafaq Aljifri, Hind Abdullah Ebrahim Abdullah, Hanan Ali Zurba
    Medicine.2025; 104(22): e42643.     CrossRef
  • Sepsis incidence, suspicion, prediction and mortality in emergency medical services: a cohort study related to the current international sepsis guideline
    Silke Piedmont, Ludwig Goldhahn, Enno Swart, Bernt-Peter Robra, Carolin Fleischmann-Struzek, Rajan Somasundaram, Wolfgang Bauer
    Infection.2024; 52(4): 1325.     CrossRef
  • Most patients with an increased risk for sepsis-related morbidity or death do not recognize sepsis as a medical emergency: results of a survey study using case vignettes
    Sebastian Born, Carolin Fleischmann-Struzek, Wiltrud Abels, Silke Piedmont, Edmund Neugebauer, Konrad Reinhart, Evjenia Toubekis, Odette Wegwarth, Daniel Schwarzkopf
    Critical Care.2023;[Epub]     CrossRef
  • Assessing Awareness and Actions Must Be Taken in Acute Myocardial Infarction: A Cross-Sectional Study on the General Population in Alahssa, Saudi Arabia
    Abdullah Almaqhawi, Abdullah Alkhalaf, Mohammed Al Qadhib, Ali M Alhashim, Norah S Alsaad, Mshari S Alqahtani, Mohammed Alqahtani, Osama F Alamri, Fatimah Buali, Ibraheem Alhusain
    Cureus.2023;[Epub]     CrossRef
  • Text-Based vs. Graphical Information Formats in Sepsis Prevention and Early Detection: A Randomized Controlled Trial on Informed Choice
    Luka Johanna Debbeler, Anne Pohrt, Carolin Fleischmann-Struzek, Daniel Schwarzkopf, Sebastian Born, Konrad Reinhart, Odette Wegwarth
    Journal of Clinical Medicine.2022; 11(13): 3659.     CrossRef
  • Public awareness and knowledge of sepsis: a cross-sectional survey of adults in Canada
    Jeanna Parsons Leigh, Rebecca Brundin-Mather, Stephana Julia Moss, Angie Nickel, Ariana Parolini, Deirdre Walsh, Blair L. Bigham, Alix J. E. Carter, Alison Fox-Robichaud, Kirsten M. Fiest
    Critical Care.2022;[Epub]     CrossRef
  • Public Awareness of Sepsis Compared to Acute Myocardial Infarction and Stroke in Jeddah, Saudi Arabia: Questionnaire Study
    Nourah Al-Orainan, Adel Mohamed EL-Shabasy, Khawlah Alamin Al-Shanqiti, Rawan Awad Al-Harbi, Hadeel Rajeh Alnashri, Raghad Ahmed Rezqallah, Alanoud Abdallah Mirghani
    Interactive Journal of Medical Research.2020; 9(2): e16195.     CrossRef
  • Korean Registry for Improving Sepsis Survival (KISS): Protocol for a Multicenter Cohort of Adult Patients with Sepsis or Septic Shock
    Jong Hun Kim, Nam Su Ku, Youn Jeong Kim, Hong Bin Kim, Hyeri Seok, Dong-Gun Lee, Jin Seo Lee, Su Jin Jeong, Jung-Hyun Choi, Jang Wook Sohn, Min Ja Kim, Dae Won Park
    Infection & Chemotherapy.2020; 52(1): 31.     CrossRef
  • Level of Knowledge on Stroke and Associated Factors: A Cross-Sectional Study at Primary Health Care Centers in Morocco
    Ahmed Kharbach, Majdouline Obtel, Abderrahmane Achbani, Youssef Bouchriti, Kenza Hassouni, Laila Lahlou, Rachid Razine
    Annals of Global Health.2020;[Epub]     CrossRef
  • Development of questionnaire on awareness and action towards symptoms and risk factors of heart attack and stroke among a Malaysian population
    Abdullah Abdulmajid Abdo Ahmed, Abdulkareem Mohammed AL-Shami, Shazia Jamshed, Abdul Rahman Fata Nahas
    BMC Public Health.2019;[Epub]     CrossRef
  • Determinants of sepsis knowledge: a representative survey of the elderly population in Germany
    Sarah Eitze, Carolin Fleischmann-Struzek, Cornelia Betsch, Konrad Reinhart
    Critical Care.2018;[Epub]     CrossRef
  • Assessment of the general public's knowledge of stroke: A cross-sectional study in Yaoundé, Cameroon
    Jobert Richie Nansseu, Cedric Paterson Atangana, Saint-Just N. Petnga, Joseph Kamtchum-Tatuene, Jean Jacques Noubiap
    Journal of the Neurological Sciences.2017; 378: 123.     CrossRef
  • Public Awareness of Sepsis Is Low in Sweden
    Lisa Mellhammar, Bertil Christensson, Adam Linder
    Open Forum Infectious Diseases.2015;[Epub]     CrossRef
  • 17,094 View
  • 166 Download
  • 14 Web of Science
  • 14 Crossref
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CEEM : Clinical and Experimental Emergency Medicine