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"Dong Hoon Kim"

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"Dong Hoon Kim"

Original Article

Toxicology

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Therapeutic effect of ascorbic acid on dapsone-induced methemoglobinemia in rats
Clin Exp Emerg Med. 2018;5(3):192-198.   Published online September 30, 2018
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Therapeutic effect of ascorbic acid on dapsone-induced methemoglobinemia in rats
Clin Exp Emerg Med. 2018;5(3):192-198.   Published online September 30, 2018
Close
Objective
Dapsone (diaminodiphenyl sulfone, DDS) is currently used to treat leprosy, malaria, dermatitis herpetiformis, and other diseases. It is also used to treat pneumocystis pneumonia and Toxoplasma gondii infection in HIV-positive patients. The most common adverse effect of DDS is methemoglobinemia from oxidative stress. Ascorbic acid is an antioxidant and reducing agent that scavenges the free radicals produced by oxidative stress. The present study aimed to investigate the effect of ascorbic acid in the treatment of DDS induced methemoglobinemia.
Methods
Male Sprague-Dawley rats were divided into three groups: an ascorbic acid group, a methylene blue (MB) group, and a control group. After DDS (40 mg/kg) treatment via oral gavage, ascorbic acid (15 mg/kg), MB (1 mg/kg), or normal saline were administered via tail vein injection. Depending on the duration of the DDS treatment, blood methemoglobin levels, as well as the nitric oxide levels and catalase activity, were measured at 60, 120, or 180 minutes after DDS administration.
Results
Methemoglobin concentrations in the ascorbic acid and MB groups were significantly lower compared to those in the control group across multiple time points. The plasma nitric oxide levels and catalase activity were not different among the groups or time points.
Conclusion
Intravenous ascorbic acid administration is effective in treating DDS-induced methemoglobinemia in a murine model.

Citations

Citations to this article as recorded by  Crossref logo
  • Congenital methaemoglobinaemia in pregnancy
    Anusha Tamma Reddy, Manisha Madhai Beck, Greeshma Grace Thomas, Nitish Vijayanand
    BMJ Case Reports.2025; 18(5): e263737.     CrossRef
  • Alpha-Lipoic Acid Reduces Methemoglobin and Oxidative Imbalance in the Blood and Liver Induced by Dapsone in Mice: Molecular Mechanism of Antioxidant Action
    Savio Monteiro dos Santos, Joni Tetsuo Sakai, Bruno Alexandre Quadros Gomes, Lisa Maria Mendes de Almeida Souza, Roseane Guimarães Ferreira, Kaio Murilo Monteiro Espíndola, Ana Flávia Oliveira Pampolha, Kelly Davis, Pamela Suelen da S. Seabra, Larissa de
    ACS Pharmacology & Translational Science.2025; 8(7): 2153.     CrossRef
  • Ascorbic Acid for Methemoglobinemia Treatment: A Case Report and Literature Review
    Kelli R Keats, Rachel Robinson, Mallika Patel, Alexis Wallace, Stephanie Albrecht
    Journal of Pharmacy Practice.2024; 37(4): 1015.     CrossRef
  • The Potential Effect of Dapsone on the Inflammatory Reactions in COVID-19: Staggering View
    Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Engy Elekhnawy, Athanasios Alexiou, Gaber El-Saber Batiha
    Combinatorial Chemistry & High Throughput Screening.2024; 27(5): 674.     CrossRef
  • Free Radical Scavenging Activity of Boron and Vitamin C in Nitrite-Induced Hemoglobin Oxidation Model: In vitro and in vivo Studies
    Hozan Jaza Hama Salh, Tavga Ahmed Aziz, Zheen Aorahman Ahmed, Dlivan Fattah Aziz
    Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ).2023; 5: 157.     CrossRef
  • Hemolytic anemia in COVID-19
    Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Ajeet Kaushik, Małgorzata Kujawska, Gaber El-Saber Batiha
    Annals of Hematology.2022; 101(9): 1887.     CrossRef
  • Methaemoglobinaemia in pregnancy: Real world experience in a single centre in Malaysia
    Andy Sing Ong Tang, Kok Choon Cheah, Tze Shin Leong, Lee Ping Chew
    Proceedings of Singapore Healthcare.2022;[Epub]     CrossRef
  • Rapid Potentiometric Determination of Ascorbic Acid Using Iodate as a Reagent
    Anita Martinović Bevanda, Antonela Matić, Stanislava Talić, Anita Ivanković, Ante Prkić, Andrea Paut, Tina Vukušić
    International Journal of Electrochemical Science.2022; 17(7): 220730.     CrossRef
  • Methemoglobinemia due to prilocaine use during jaw deformity surgery: A case report
    Naoko Tsunoda, Tadashi Kawai, Kei Onodera, Yuko Komatsu, Shuu Suzuki, Toshimi Chiba, Hiroyuki Yamada
    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2020; 32(5): 377.     CrossRef
  • Role of ascorbic acid in dapsone induced methemoglobinemia
    Kamal Kant Sahu, Ajay Kumar Mishra
    Clinical and Experimental Emergency Medicine.2019; 6(1): 91.     CrossRef
  • Methemoglobinemia: Infants at risk
    Sarah Fossen Johnson
    Current Problems in Pediatric and Adolescent Health Care.2019; 49(3): 57.     CrossRef
  • 19,140 View
  • 196 Download
  • 13 Web of Science
  • 11 Crossref

Case Report

Neurology

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Non-aneurysmal and non-traumatic subarachnoid hemorrhage after attempted suicide by incomplete hanging
Clin Exp Emerg Med. 2017;4(1):56-59.   Published online March 30, 2017
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Non-aneurysmal and non-traumatic subarachnoid hemorrhage after attempted suicide by incomplete hanging
Clin Exp Emerg Med. 2017;4(1):56-59.   Published online March 30, 2017
Close
Hanging is a common method of suicide that is being reported more frequently in many countries. Several complications including injuries to the cervical spine, neck vessels, and brain can occur after attempted suicide by hanging. There are only a few reports of brain computed tomography and magnetic resonance imaging of hanging victims. The most common abnormality was diffuse cerebral edema. A subarachnoid hemorrhage is an atypical complication by suicidal hanging. We report a case of a female patient who presented to an emergency department with altered mental status after attempting suicide by incomplete hanging. The patient was diagnosed with a non-aneurysmal and non-traumatic subarachnoid hemorrhage. This case shows that spontaneous subarachnoid hemorrhage can develop due to a sudden elevation of intracranial pressure, as occurs with hanging.

Citations

Citations to this article as recorded by  Crossref logo
  • Depression as a risk factor for Alzheimer’s disease: A human post-mortem study
    Mizuki Morisaki, Farnoosh Rezaali, Laurie C. Lau, Delphine Boche, Golam M. Khandaker, Gustavo Turecki, Lindsey I. Sinclair, Mu-Hong Chen
    PLOS ONE.2025; 20(4): e0320561.     CrossRef
  • Subdural hemorrhage in hanging deaths: a retrospective case–control study
    Dalia Alsaif, Musaed Alfares, Omar Baadheem, Mohammed Madadin, Yahya Alshaikhi, Magdy Khroshah
    Egyptian Journal of Forensic Sciences.2025;[Epub]     CrossRef
  • Subarachnoid Hemorrhage Confirmed by Magnetic Resonance Imaging in a Patient with Brain Death owing to Hypoxic Encephalopathy Following Suicide by Hanging
    Sotaro OSHIDA, Tomoki YOKOSAWA, Shizuka ARAYA, Shinpei SATO, Taro SUZUKI, Yosuke AKAMATSU, Kuniaki OGASAWARA
    NMC Case Report Journal.2024; 11: 61.     CrossRef
  • A Case of Hanging with Limited Specific Postmortem Brain Imaging
    Arata NAGAI, Tomoya KOBAYASHI, Kyuzo KUROSAWA, Kuniyasu NIIZUMA, Hidenori ENDO
    NMC Case Report Journal.2024; 11: 249.     CrossRef
  • Intracerebral and subarachnoid hemorrhage after suicidal “near-hanging”
    Nathalie Schwab, Lorena Díaz, Ignasi Galtés
    International Journal of Legal Medicine.2022; 136(5): 1359.     CrossRef
  • Traumatic Rupture of the Middle Cerebral Artery Followed by Acute Basal Subarachnoid Hemorrhage: Tailored Approach in Forensic Pathology by Aid of Post-mortem Angiographic Findings
    Sohyung Park, Sookyoung Lee, Kyung-moo Yang, Dukhoon Kim, Heon Lee, Jang Gyu Cha
    Korean Journal of Legal Medicine.2019; 43(1): 23.     CrossRef
  • Hounsfield units in pseudo subarachnoid hemorrhage: worth looking for
    Subramanian Senthilkumaran, Nanjundan Karthikeyan, Namasivayam Balamurugan, Ponniah Thirumalaikolundusubramanian
    Clinical and Experimental Emergency Medicine.2017; 4(3): 186.     CrossRef
  • Characteristics of Mexican children and adolescents who died by suicide: A study of psychological autopsies
    Thelma Beatriz González-Castro, Carlos Alfonso Tovilla-Zárate, Yazmín Hernández-Díaz, Isela E. Juárez-Rojop, Alejandra Giovanna León-Garibay, Crystell Guadalupe Guzmán-Priego, Lilia López-Narváez, Ana Frésan
    Journal of Forensic and Legal Medicine.2017; 52: 236.     CrossRef
  • 29,045 View
  • 157 Download
  • 5 Web of Science
  • 8 Crossref
Original Article

Critical Care

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Awareness and knowledge of sepsis in the general Korean population: comparison with the awareness and knowledge of acute myocardial infarction and stroke
Clin Exp Emerg Med. 2014;1(1):41-48.   Published online September 30, 2014
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Awareness and knowledge of sepsis in the general Korean population: comparison with the awareness and knowledge of acute myocardial infarction and stroke
Clin Exp Emerg Med. 2014;1(1):41-48.   Published online September 30, 2014
Close
Objective

Patients with severe sepsis or septic shock require timely, aggressive management to improve their outcomes, and early presentation of patients to the hospital may also be important. Thus, public awareness about sepsis may be important for improved outcomes. However, there are no studies regarding the public awareness of sepsis in the general Korean population. Therefore, the objective of this survey was to gain insight into the public awareness of sepsis.

Methods

Prospective paper-based and web-based surveys were issued between May and June 2013 to adults aged ≥18 years.

Results

A total of 1,081 participants responded to the survey (394 paper-based and 687 web-based). Mean age was 38.7±11.4 years, and 541 participants (50%) were men. Of the 1,081 participants, 831 (76.9%) had heard of the term “sepsis.” Of these participants, only 295 (35%) responded correctly regarding the definition of sepsis. However, 1,019 participants (94.3%) had heard of acute myocardial infarction, and 817 of these (80%) correctly defined acute myocardial infarction. Regarding stroke, 1,047 (96.9%) had heard of stroke, and 975 of these responded (93.1%) correctly to the definition of stroke.

Conclusion

There is poor public awareness about sepsis compared with that of acute myocardial infarction and stroke. This may limit the timely management of severe sepsis and septic shock.

Citations

Citations to this article as recorded by  Crossref logo
  • The Role of Perceived Urgency and Barriers in Using Emergency Medical Care for Sepsis: A German-Wide, Representative Survey Using Case Vignettes
    Sebastian Born, Norman Rose, Silke Piedmont, Daniel Schwarzkopf, Mathias W. Pletz, Wiltrud Abels, Konrad Reinhart, Carolin Fleischmann-Struzek
    Critical Care Medicine.2026; 54(2): 291.     CrossRef
  • Public knoweldge of sepsis in Saudi Arabia: A cross-sectional study
    Kadejh Abdulrahman Bashekah, Alla Hussain Felemban, Lubna Abdulrahman Hafiz, Abdulrahman Mauafaq Aljifri, Dalal Nasser Gaith Alsharif, Abdulaziz Ahmad Albarakati, Hind Mauafaq Aljifri, Sarah Mauafaq Aljifri, Hind Abdullah Ebrahim Abdullah, Hanan Ali Zurba
    Medicine.2025; 104(22): e42643.     CrossRef
  • Sepsis incidence, suspicion, prediction and mortality in emergency medical services: a cohort study related to the current international sepsis guideline
    Silke Piedmont, Ludwig Goldhahn, Enno Swart, Bernt-Peter Robra, Carolin Fleischmann-Struzek, Rajan Somasundaram, Wolfgang Bauer
    Infection.2024; 52(4): 1325.     CrossRef
  • Most patients with an increased risk for sepsis-related morbidity or death do not recognize sepsis as a medical emergency: results of a survey study using case vignettes
    Sebastian Born, Carolin Fleischmann-Struzek, Wiltrud Abels, Silke Piedmont, Edmund Neugebauer, Konrad Reinhart, Evjenia Toubekis, Odette Wegwarth, Daniel Schwarzkopf
    Critical Care.2023;[Epub]     CrossRef
  • Assessing Awareness and Actions Must Be Taken in Acute Myocardial Infarction: A Cross-Sectional Study on the General Population in Alahssa, Saudi Arabia
    Abdullah Almaqhawi, Abdullah Alkhalaf, Mohammed Al Qadhib, Ali M Alhashim, Norah S Alsaad, Mshari S Alqahtani, Mohammed Alqahtani, Osama F Alamri, Fatimah Buali, Ibraheem Alhusain
    Cureus.2023;[Epub]     CrossRef
  • Text-Based vs. Graphical Information Formats in Sepsis Prevention and Early Detection: A Randomized Controlled Trial on Informed Choice
    Luka Johanna Debbeler, Anne Pohrt, Carolin Fleischmann-Struzek, Daniel Schwarzkopf, Sebastian Born, Konrad Reinhart, Odette Wegwarth
    Journal of Clinical Medicine.2022; 11(13): 3659.     CrossRef
  • Public awareness and knowledge of sepsis: a cross-sectional survey of adults in Canada
    Jeanna Parsons Leigh, Rebecca Brundin-Mather, Stephana Julia Moss, Angie Nickel, Ariana Parolini, Deirdre Walsh, Blair L. Bigham, Alix J. E. Carter, Alison Fox-Robichaud, Kirsten M. Fiest
    Critical Care.2022;[Epub]     CrossRef
  • Public Awareness of Sepsis Compared to Acute Myocardial Infarction and Stroke in Jeddah, Saudi Arabia: Questionnaire Study
    Nourah Al-Orainan, Adel Mohamed EL-Shabasy, Khawlah Alamin Al-Shanqiti, Rawan Awad Al-Harbi, Hadeel Rajeh Alnashri, Raghad Ahmed Rezqallah, Alanoud Abdallah Mirghani
    Interactive Journal of Medical Research.2020; 9(2): e16195.     CrossRef
  • Korean Registry for Improving Sepsis Survival (KISS): Protocol for a Multicenter Cohort of Adult Patients with Sepsis or Septic Shock
    Jong Hun Kim, Nam Su Ku, Youn Jeong Kim, Hong Bin Kim, Hyeri Seok, Dong-Gun Lee, Jin Seo Lee, Su Jin Jeong, Jung-Hyun Choi, Jang Wook Sohn, Min Ja Kim, Dae Won Park
    Infection & Chemotherapy.2020; 52(1): 31.     CrossRef
  • Level of Knowledge on Stroke and Associated Factors: A Cross-Sectional Study at Primary Health Care Centers in Morocco
    Ahmed Kharbach, Majdouline Obtel, Abderrahmane Achbani, Youssef Bouchriti, Kenza Hassouni, Laila Lahlou, Rachid Razine
    Annals of Global Health.2020;[Epub]     CrossRef
  • Development of questionnaire on awareness and action towards symptoms and risk factors of heart attack and stroke among a Malaysian population
    Abdullah Abdulmajid Abdo Ahmed, Abdulkareem Mohammed AL-Shami, Shazia Jamshed, Abdul Rahman Fata Nahas
    BMC Public Health.2019;[Epub]     CrossRef
  • Determinants of sepsis knowledge: a representative survey of the elderly population in Germany
    Sarah Eitze, Carolin Fleischmann-Struzek, Cornelia Betsch, Konrad Reinhart
    Critical Care.2018;[Epub]     CrossRef
  • Assessment of the general public's knowledge of stroke: A cross-sectional study in Yaoundé, Cameroon
    Jobert Richie Nansseu, Cedric Paterson Atangana, Saint-Just N. Petnga, Joseph Kamtchum-Tatuene, Jean Jacques Noubiap
    Journal of the Neurological Sciences.2017; 378: 123.     CrossRef
  • Public Awareness of Sepsis Is Low in Sweden
    Lisa Mellhammar, Bertil Christensson, Adam Linder
    Open Forum Infectious Diseases.2015;[Epub]     CrossRef
  • 17,094 View
  • 166 Download
  • 14 Web of Science
  • 14 Crossref