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"Gil Joon Suh"

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"Gil Joon Suh"

Original Articles

Resuscitation

Lower post-rewarming body control temperature is associated with 1-year mortality of out-ofhospital cardiac arrest
Heesu Park, Jongwhan shin, Dong Keon Lee, Jungeun Lee, Mijung Yun, Heeye Lim, Jernghun Kim, Gil Joon Suh
In Press, Received July 17, 2025  Accepted October 15, 2025  Available online January 28, 2026  
DOI: https://doi.org/10.15441/ceem.25.158    [Accepted]

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Lower post-rewarming body control temperature is associated with 1-year mortality of out-ofhospital cardiac arrest
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Lower post-rewarming body control temperature is associated with 1-year mortality of out-ofhospital cardiac arrest
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Objective
To determine the relationship between post-rewarming control temperature and neurological outcomes in multicenter post cardiac arrest syndrome (PCAS) registry in South Korea.
Methods
We retrospectively analyzed the PCAS registry, which prospectively enrolled out-of-hospital cardiac arrest (OHCA) patients with sustained return of spontaneous circulation in the emergency departments of three urban hospitals from December 2013 to April 2021. Patients who received targeted temperature management (TTM) were included. Body temperature was measured at 4-hour intervals during the first 72 hours after the initiation of TTM. The post-rewarming control temperature was defined as the body temperature measured at 72 hours after TTM initiation. The primary outcome was favorable neurological outcomes, defined as cerebral performance category (CPC) 1-2 at 1-year, and secondary outcome was 1-year mortality.
Results
Of the 1,591 patients in the registry, 289 were included in the analysis. A favorable neurological outcome occurred in 75 patients (25.9%). Patients with favorable neurological outcomes exhibited higher body temperature at 4 hours and during 48-72 hours of TTM than those with unfavorable neurological outcomes. Body temperature at 72h of TTM was independently associated with 1-year mortality (adjusted odds ratio [aOR], 0.51; 95% confidence interval, 0.37-0.87; p=0.011), but not with 1-year favorable neurological outcomes (aOR, 1.10; 95% CI, 0.77–1.56; p= 0.573).
Conclusion
Low body temperature at 72 hours after TTM was independently associated with 1-year mortality.
  • 279 View
  • 3 Download

Experimental study

Protective role of kallistatin in oxygen-glucose deprivation and reoxygenation in human umbilical vein endothelial cells
Young Woo Um, Woon Yong Kwon, Seung-Yong Seong, Gil Joon Suh
Clin Exp Emerg Med 2024;11(1):43-50.   Published online March 21, 2024
DOI: https://doi.org/10.15441/ceem.23.106

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Protective role of kallistatin in oxygen-glucose deprivation and reoxygenation in human umbilical vein endothelial cells
Clin Exp Emerg Med. 2024;11(1):43-50.   Published online March 21, 2024
DOI: https://doi.org/10.15441/ceem.23.106
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Protective role of kallistatin in oxygen-glucose deprivation and reoxygenation in human umbilical vein endothelial cells
Clin Exp Emerg Med. 2024;11(1):43-50.   Published online March 21, 2024
DOI: https://doi.org/10.15441/ceem.23.106
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Objective
Ischemia-reperfusion (IR) injury is implicated in various clinical diseases. Kallistatin attenuates oxidative stress, and its deficiency has been associated with poor neurological outcomes after cardiac arrest. The present study investigated the antioxidant mechanism through which kallistatin prevents IR injury.
Methods
Human umbilical vein endothelial cells (HUVECs) were transfected with small interfering RNA (siRNA) targeting the human kallistatin gene (SERPINA4). Following SERPINA4 knockdown, the level of kallistatin expression was measured. To induce IR injury, HUVECs were exposed to 24 h of oxygen-glucose deprivation and reoxygenation (OGD/R). To evaluate the effect of SERPINA4 knockdown on OGD/R, cell viability and the concentration of kallistatin, endothelial nitric oxide synthase (eNOS) and total NO were measured.
Results
SERPINA4 siRNA transfection suppressed the expression of kallistatin in HUVECs. Exposure to OGD/R reduced cell viability, and this effect was more pronounced in SERPINA4 knockdown cells compared with controls. SERPINA4 knockdown significantly reduced kallistatin concentration regardless of OGD/R, with a more pronounced effect observed without OGD/R. Furthermore, SERPINA4 knockdown significantly decreased eNOS concentrations induced by OGD/R (P<0.01) but did not significantly affect the change in total NO concentration (P=0.728).
Conclusion
The knockdown of SERPINA4 resulted in increased vulnerability of HUVECs to OGD/R and significantly affected the change in eNOS level induced by OGD/R. These findings suggest that the protective effect of kallistatin against IR injury may contribute to its eNOS-promoting effect.

Citations

Citations to this article as recorded by  Crossref logo
  • Etiology-specific prognostic value of ultra-early diffusion-weighted MRI after out-of-hospital cardiac arrest: a multicenter cohort study
    Jin Hong Min, Yeonho You, Jung Soo Park, Changshin Kang, Hyun Shik Ryu, Wonjoon Jeong, Se Kwang Oh, So Young Jeon, In Ho Lee, Hye Seon Jeong, Sung Phil Chung, Rachel Beekman, Byung Kook Lee, Dong Hun Lee
    Critical Care.2026;[Epub]     CrossRef
  • Kallistatin Improves Lipid Metabolism and Alleviates Cardiac Hypertrophy via the SIRT1/PPAR Pathway: An Experimental Study
    Bing Li, Yanping Wu, Ya Li, Yonggang Yuan, Xianbo Zhou, Zesheng Xu, JinKun Wen
    Journal of Biochemical and Molecular Toxicology.2025;[Epub]     CrossRef
  • 7,379 View
  • 111 Download
  • 2 Web of Science
  • 2 Crossref

Review Article

Critical Care

Hemodynamic management of septic shock: beyond the Surviving Sepsis Campaign guidelines
Gil Joon Suh, Tae Gun Shin, Woon Yong Kwon, Kyuseok Kim, You Hwan Jo, Sung-Hyuk Choi, Sung Phil Chung, Won Young Kim, for the Korean Shock Society investigators
Clin Exp Emerg Med 2023;10(3):255-264.   Published online July 13, 2023
DOI: https://doi.org/10.15441/ceem.23.065

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Hemodynamic management of septic shock: beyond the Surviving Sepsis Campaign guidelines
Clin Exp Emerg Med. 2023;10(3):255-264.   Published online July 13, 2023
DOI: https://doi.org/10.15441/ceem.23.065
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Hemodynamic management of septic shock: beyond the Surviving Sepsis Campaign guidelines
Clin Exp Emerg Med. 2023;10(3):255-264.   Published online July 13, 2023
DOI: https://doi.org/10.15441/ceem.23.065
Close
Although the Surviving Sepsis Campaign guidelines provide standardized and generalized guidance, they are less individualized. This review focuses on recent updates in the hemodynamic management of septic shock. Monitoring and intervention for septic shock should be personalized according to the phase of shock. In the salvage phase, fluid resuscitation and vasopressors should be given to provide life-saving tissue perfusion. During the optimization phase, tissue perfusion should be optimized. In the stabilization and de-escalation phases, minimal fluid infusion and safe fluid removal should be performed, respectively, while preserving organ perfusion. There is controversy surrounding the use of restrictive versus liberal fluid strategies after initial resuscitation. Fluid administration after initial resuscitation should depend upon the patient’s fluid responsiveness and requires individualized management. A number of dynamic tests have been proposed to monitor fluid responsiveness, which can help clinicians decide whether to give fluid or not. The optimal timing for the initiation of vasopressor agents is unknown. Recent data suggest that early vasopressor initiation should be considered. Inotropes can be considered in patients with decreased cardiac contractility associated with impaired tissue perfusion despite adequate volume status and arterial blood pressure. Venoarterial extracorporeal membrane oxygenation should be considered for refractory septic shock with severe cardiac systolic dysfunction.

Citations

Citations to this article as recorded by  Crossref logo
  • Red Blood Cell Transfusion Beyond Restrictive Thresholds in Patients With Septic Shock and an Elevated Lactate Level: A Multicenter Observational Study
    Kyung Hun Yoo, Gil Joon Suh, Woon Yong Kwon, Sung-Hyuk Choi, Sung Phil Chung, Won Young Kim, Kyuseok Kim, Yoo Seok Park, Tae Gun Shin, Byuk Sung Ko, Tae Ho Lim, Yongil Cho
    Journal of Korean Medical Science.2026;[Epub]     CrossRef
  • The impact of ketamine on ICU mortality in patients with sepsis: A retrospective cohort study
    Yifei Liu, Jie Yue, Guangdong Wang, Yuxia Jiang, Aihua Shu
    Journal of Critical Care.2026; 92: 155422.     CrossRef
  • Comparison of prognosis in emergency department elderly septic shock patients with initial hypotension versus delayed hypotension
    Chaeeun Lee, Gil Joon Suh, Sung-Hyuk Choi, Sung Phil Chung, Won Young Kim, Tae Ho Lim, Sangchun Choi, Tae Gun Shin, Sangun Nah, Sangsoo Han
    European Journal of Emergency Medicine.2026;[Epub]     CrossRef
  • Urinary biomarkers for diagnosing acute kidney injury in sepsis in the emergency department
    Sumin Baek, Inwon Park, Seonghye Kim, Young Woo Um, Hee Eun Kim, Kyunghoon Lee, Jae Hyuk Lee, You Hwan Jo
    Heliyon.2025; 11(1): e41252.     CrossRef
  • Comparison between norepinephrine plus epinephrine and norepinephrine plus vasopressin after return of spontaneous circulation in patients with out-of-hospital cardiac arrest
    Sejoong Ahn, Bo-Yeong Jin, Sukyo Lee, Jong-Hak Park, Hanjin Cho, Sungwoo Moon, Sang Kuk Han, Phil Cho Choi, Young Hwan Lee, Sang O. Park, Jong Seok Lee, Ki Young Jeong, Sung Hyuk Choi, Young Hoon Yoon, Su Jin Kim, Kap Su Han, Min Seob Sim, Gun Tak Lee, Yo
    Scientific Reports.2025;[Epub]     CrossRef
  • Using machine learning techniques for early prediction of tracheal intubation in patients with septic shock: a multi-center study in South Korea
    Ji Han Heo, Taegyun Kim, Tae Gun Shin, Gil Joon Suh, Woon Yong Kwon, Hayoung Kim, Heesu Park, Heejun Kim, Sol Han
    Acute and Critical Care.2025; 40(2): 221.     CrossRef
  • Sepsis Heterogeneity and Precision Medicine: Typing Challenges from Clinical Syndromes to Molecular Mechanisms
    硕 盛
    Journal of Clinical Personalized Medicine.2025; 04(03): 259.     CrossRef
  • The evolving landscape of emergency care
    Lewis J. Kaplan
    Current Opinion in Critical Care.2025; 31(3): 235.     CrossRef
  • Prognostic Value of the AST/ALT Ratio in Patients with Septic Shock: A Prospective, Multicenter, Registry-Based Observational Study
    Sungwoo Choi, Sangun Nah, Gil Joon Suh, Sung-Hyuk Choi, Sung Phil Chung, Won Young Kim, Tae Ho Lim, Sangchun Choi, Tae Gun Shin, Sangsoo Han
    Diagnostics.2025; 15(14): 1773.     CrossRef
  • From Fluid Responsiveness to Prognosis: The Emerging Role of Point-of-Care Echocardiography in Sepsis
    Andrea Piccioni, Gloria Rozzi, Giacomo Spaziani, Michela Novelli, Mariella Fuorlo, Marcello Candelli, Giulia Pignataro, Luca Santarelli, Marcello Covino, Antonio Gasbarrini, Francesco Franceschi
    Diagnostics.2025; 15(20): 2612.     CrossRef
  • Impact of diastolic blood pressure time under range on mortality and acute kidney injury in septic patients: a retrospective cohort study
    Jian Zhao, Si Tong Lin, Ai Hua Qin, Cheng Rui Zhou, Xiang Dong Huang, Hua Guo Chen, Shu Qin Zhou, Hu Peng, Yuan Zhuo Chen
    BMC Anesthesiology.2025;[Epub]     CrossRef
  • Comparison of non-invasive strategies to drive fluid resuscitation in sepsis or septic shock: a meta-analysis of RCTs
    Mara Graziani, Laura Gasperini, Claudia Gasperini, Giorgio Maraziti, Gennaro De Pascale, Cecilia Becattini
    Internal and Emergency Medicine.2025;[Epub]     CrossRef
  • Effect of Intravenous Push and Piggyback Administration of Ceftriaxone on Mortality in Sepsis
    Sun Young Lim, Sumin Baek, You Hwan Jo, Jae Hyuk Lee, Young Woo Um, Hee Eun Kim, Dongkwan Han
    The Journal of Emergency Medicine.2024; 66(5): e632.     CrossRef
  • Temperature trajectories and mortality in hypothermic sepsis patients
    Dongkwan Han, Seung Hyun Kang, Young Woo Um, Hee Eun Kim, Ji Eun Hwang, Jae Hyuk Lee, You Hwan Jo, Yoon Sun Jung, Hui Jai Lee
    The American Journal of Emergency Medicine.2024; 84: 18.     CrossRef
  • Comparison of Early and Late Norepinephrine Administration in Patients With Septic Shock
    Chiwon Ahn, Gina Yu, Tae Gun Shin, Youngsuk Cho, Sunghoon Park, Gee Young Suh
    CHEST.2024; 166(6): 1417.     CrossRef
  • Removal of circulating mitochondrial N-formyl peptides via immobilized antibody therapy restores sepsis-induced neutrophil dysfunction
    Woon Yong Kwon, Yoon Sun Jung, Gil Joon Suh, Sung Hee Kim, Areum Lee, Jeong Yeon Kim, Hayoung Kim, Heesu Park, Jieun Shin, Taegyun Kim, Kyung Su Kim, Kiyoshi Itagaki, Carl J Hauser
    Journal of Leukocyte Biology.2024; 116(5): 1169.     CrossRef
  • Diagnostic Accuracy of Plasma Renin Concentration and Renin Activity in Predicting Mortality and Kidney Outcomes in Patients With Septic Shock and Hypoperfusion or Hypotension: A Multicenter, Prospective, Observational Study
    Gun Tak Lee, Byuk Sung Ko, Da Seul Kim, Minha Kim, Jong Eun Park, Sung Yeon Hwang, Daun Jeong, Chi Ryang Chung, Hyunggoo Kang, Jaehoon Oh, Tae Ho Lim, Bora Chae, Won Young Kim, Tae Gun Shin
    Annals of Laboratory Medicine.2024; 44(6): 497.     CrossRef
  • The mortality of patients with sepsis increases in the first month of a new academic year
    Sukyo Lee, Sungjin Kim, Sejoong Ahn, Hanjin Cho, Sungwoo Moon, Young Duck Cho, Jong-Hak Park
    Clinical and Experimental Emergency Medicine.2024; 11(2): 161.     CrossRef
  • Early Mortality Stratification with Serum Albumin and the Sequential Organ Failure Assessment Score at Emergency Department Admission in Septic Shock Patients
    Sang-Min Kim, Seung-Mok Ryoo, Tae-Gun Shin, You-Hwan Jo, Kyuseok Kim, Tae-Ho Lim, Sung-Phil Chung, Sung-Hyuk Choi, Gil-Joon Suh, Won-Young Kim
    Life.2024; 14(10): 1257.     CrossRef
  • External validation of a modified cardiovascular sequential organ failure assessment score in patients with suspected infection using the MIMIC-IV database
    Sung Yeon Hwang, Inkyu Kim, Byuk Sung Ko, Seung Mok Ryoo, Eunah Han, Hui Jai Lee, Daun Jeong, Tae Gun Shin, Kyuseok Kim, Vipa Thanachartwet
    PLOS ONE.2024; 19(11): e0312185.     CrossRef
  • PiCCO or Cardiac Ultrasound? Which Is Better for Hemodynamic Monitoring in ICU?
    Maria Andrei, Nicoleta Alice Dragoescu, Andreea Stanculescu, Luminita Chiutu, Octavian Dragoescu, Octavian Istratoaie
    Medicina.2024; 60(11): 1884.     CrossRef
  • Assessment of organ failure in sepsis patients in the emergency department: clinical evaluation, Sequential Organ Failure Assessment (SOFA) score, and future perspectives
    Tae Gun Shin
    Clinical and Experimental Emergency Medicine.2024; 11(4): 327.     CrossRef
  • Hemşirelerin Sepsis Farkındalığı ve Sepsis Tanılı Hastalarda Hemşirelik Yönetimi
    Pınar Erman, Güler Balcı Alparslan
    Yoğun Bakım Hemşireliği Dergisi.2024; 28(3): 213.     CrossRef
  • 37,908 View
  • 7,241 Download
  • 20 Web of Science
  • 23 Crossref
Original Articles
A quick Sequential Organ Failure Assessment–negative result at triage is associated with low compliance with sepsis bundles: a retrospective analysis of a multicenter prospective registry
Heesu Park, Tae Gun Shin, Won Young Kim, You Hwan Jo, Yoon Jung Hwang, Sung-Hyuk Choi, Tae Ho Lim, Kap Su Han, Jonghwan Shin, Gil Joon Suh, Gu Hyun Kang, Kyung Su Kim, Korean Shock Society investigators
Clin Exp Emerg Med 2022;9(2):84-92.   Published online June 30, 2022
DOI: https://doi.org/10.15441/ceem.22.230

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A quick Sequential Organ Failure Assessment–negative result at triage is associated with low compliance with sepsis bundles: a retrospective analysis of a multicenter prospective registry
Clin Exp Emerg Med. 2022;9(2):84-92.   Published online June 30, 2022
DOI: https://doi.org/10.15441/ceem.22.230
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A quick Sequential Organ Failure Assessment–negative result at triage is associated with low compliance with sepsis bundles: a retrospective analysis of a multicenter prospective registry
Clin Exp Emerg Med. 2022;9(2):84-92.   Published online June 30, 2022
DOI: https://doi.org/10.15441/ceem.22.230
Close
Objective
We investigated the effects of a quick Sequential Organ Failure Assessment (qSOFA)–negative result (qSOFA score <2 points) at triage on the compliance with sepsis bundles among patients with sepsis who presented to the emergency department (ED).
Methods
Prospective sepsis registry data from 11 urban tertiary hospital EDs between October 2015 and April 2018 were retrospectively reviewed. Patients who met the Third International Consensus Definitions for Sepsis and Septic Shock criteria were included. Primary exposure was defined as a qSOFA score ≥2 points at ED triage. The primary outcome was defined as 3-hour bundle compliance, including lactate measurement, blood culture, broad-spectrum antibiotics administration, and 30 mL/kg crystalloid administration. Multivariate logistic regression analysis to predict 3-hour bundle compliance was performed.
Results
Among the 2,250 patients enrolled in the registry, 2,087 fulfilled the sepsis criteria. Only 31.4% (656/2,087) of the sepsis patients had qSOFA scores ≥2 points at triage. Patients with qSOFA scores <2 points had lower lactate levels, lower SOFA scores, and a lower 28-day mortality rate. Rates of compliance with lactate measurement (adjusted odds ratio [aOR], 0.47; 95% confidence interval [CI], 0.29–0.75), antibiotics administration (aOR, 0.64; 95% CI, 0.52–0.78), and 30 mL/kg crystalloid administration (aOR, 0.62; 95% CI, 0.49–0.77) within 3 hours from triage were significantly lower in patients with qSOFA scores <2 points. However, the rate of compliance with blood culture within 3 hours from triage (aOR, 1.66; 95% CI, 1.33–2.08) was higher in patients with qSOFA scores <2 points.
Conclusion
A qSOFA-negative result at ED triage is associated with low compliance with lactate measurement, broad-spectrum antibiotics administration, and 30 mL/kg crystalloid administration within 3 hours in sepsis patients.

Citations

Citations to this article as recorded by  Crossref logo
  • Red Blood Cell Transfusion Beyond Restrictive Thresholds in Patients With Septic Shock and an Elevated Lactate Level: A Multicenter Observational Study
    Kyung Hun Yoo, Gil Joon Suh, Woon Yong Kwon, Sung-Hyuk Choi, Sung Phil Chung, Won Young Kim, Kyuseok Kim, Yoo Seok Park, Tae Gun Shin, Byuk Sung Ko, Tae Ho Lim, Yongil Cho
    Journal of Korean Medical Science.2026;[Epub]     CrossRef
  • Clinical Risk Models in Emphysematous Pyelonephritis: Toward a Unified Prognostic Approach
    Erkan Arslan
    Ibnosina Journal of Medicine and Biomedical Sciences.2026; 18(01): 006.     CrossRef
  • Prognostic Value of the AST/ALT Ratio in Patients with Septic Shock: A Prospective, Multicenter, Registry-Based Observational Study
    Sungwoo Choi, Sangun Nah, Gil Joon Suh, Sung-Hyuk Choi, Sung Phil Chung, Won Young Kim, Tae Ho Lim, Sangchun Choi, Tae Gun Shin, Sangsoo Han
    Diagnostics.2025; 15(14): 1773.     CrossRef
  • The usefulness of lactate/albumin ratio, C-reactive protein/albumin ratio, procalcitonin/albumin ratio, SOFA, and qSOFA in predicting the prognosis of patients with sepsis who presented to EDs
    Kyung Hun Yoo, Sung-Hyuk Choi, Gil Joon Suh, Sung Phil Chung, Han Sung Choi, Yoo Seok Park, You Hwan Jo, Tae Gun Shin, Tae Ho Lim, Won Young Kim, Juncheol Lee
    The American Journal of Emergency Medicine.2024; 78: 1.     CrossRef
  • Diagnostic Accuracy of Plasma Renin Concentration and Renin Activity in Predicting Mortality and Kidney Outcomes in Patients With Septic Shock and Hypoperfusion or Hypotension: A Multicenter, Prospective, Observational Study
    Gun Tak Lee, Byuk Sung Ko, Da Seul Kim, Minha Kim, Jong Eun Park, Sung Yeon Hwang, Daun Jeong, Chi Ryang Chung, Hyunggoo Kang, Jaehoon Oh, Tae Ho Lim, Bora Chae, Won Young Kim, Tae Gun Shin
    Annals of Laboratory Medicine.2024; 44(6): 497.     CrossRef
  • Impact of Point-of-Care Lactate Testing for Sepsis on Bundle Adherence and Clinical Outcomes in the Emergency Department: A Pre–Post Observational Study
    Sukyo Lee, Juhyun Song, Sungwoo Lee, Su Jin Kim, Kap Su Han, Sijin Lee
    Journal of Clinical Medicine.2024; 13(18): 5389.     CrossRef
  • Early Mortality Stratification with Serum Albumin and the Sequential Organ Failure Assessment Score at Emergency Department Admission in Septic Shock Patients
    Sang-Min Kim, Seung-Mok Ryoo, Tae-Gun Shin, You-Hwan Jo, Kyuseok Kim, Tae-Ho Lim, Sung-Phil Chung, Sung-Hyuk Choi, Gil-Joon Suh, Won-Young Kim
    Life.2024; 14(10): 1257.     CrossRef
  • Development and derivation of bacteremia prediction model in patients with hepatobiliary infection
    Jung Won Choi, Sung-Bin Chon, Sung Yeon Hwang, Tae Gun Shin, Jong Eun Park, Kyuseok Kim
    The American Journal of Emergency Medicine.2023; 73: 102.     CrossRef
  • Prognostic accuracy of initial and 24-h maximum SOFA scores of septic shock patients in the emergency department
    Tae Han Kim, Daun Jeong, Jong Eun Park, Sung Yeon Hwang, Gil Joon Suh, Sung-Hyuk Choi, Sung Phil Chung, Won Young Kim, Gun Tak Lee, Tae Gun Shin
    Heliyon.2023; 9(9): e19480.     CrossRef
  • EARLY PREDICTION OF UNEXPECTED LATENT SHOCK IN THE EMERGENCY DEPARTMENT USING VITAL SIGNS
    Hansol Chang, Weon Jung, Juhyung Ha, Jae Yong Yu, Sejin Heo, Gun Tak Lee, Jong Eun Park, Se Uk Lee, Sung Yeon Hwang, Hee Yoon, Won Chul Cha, Tae Gun Shin, Taerim Kim
    Shock.2023; 60(3): 373.     CrossRef
  • A Simple Bacteremia Score for Predicting Bacteremia in Patients with Suspected Infection in the Emergency Department: A Cohort Study
    Hyelin Han, Da Seul Kim, Minha Kim, Sejin Heo, Hansol Chang, Gun Tak Lee, Se Uk Lee, Taerim Kim, Hee Yoon, Sung Yeon Hwang, Won Chul Cha, Min Sub Sim, Ik Joon Jo, Jong Eun Park, Tae Gun Shin
    Journal of Personalized Medicine.2023; 14(1): 57.     CrossRef
  • 8,666 View
  • 232 Download
  • 11 Web of Science
  • 11 Crossref

Cardiovascular | Clinical Laboratory

Copeptin with high-sensitivity troponin at presentation is not inferior to serial troponin measurements for ruling out acute myocardial infarction
Kyung Su Kim, Gil Joon Suh, Sang Hoon Song, Yoon Sun Jung, Taegyun Kim, So Mi Shin, Min Woo Kang, Min Sung Lee
Clin Exp Emerg Med 2020;7(1):35-42.   Published online March 31, 2020
DOI: https://doi.org/10.15441/ceem.19.013

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Copeptin with high-sensitivity troponin at presentation is not inferior to serial troponin measurements for ruling out acute myocardial infarction
Clin Exp Emerg Med. 2020;7(1):35-42.   Published online March 31, 2020
DOI: https://doi.org/10.15441/ceem.19.013
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Copeptin with high-sensitivity troponin at presentation is not inferior to serial troponin measurements for ruling out acute myocardial infarction
Clin Exp Emerg Med. 2020;7(1):35-42.   Published online March 31, 2020
DOI: https://doi.org/10.15441/ceem.19.013
Close
Objective
We aimed to compare the multi-marker strategy (copeptin and high-sensitivity cardiac troponin I [hs-cTnI]) with serial hs-cTnI measurements to rule out acute myocardial infarction (AMI) in patients with chest pain.

Methods
This prospective observational study was performed in a single emergency department. To test the non-inferiority margin of 4% in terms of negative predictive value (NPV) between the multi-marker strategy (0 hour) and serial hs-cTnI measurements (0 and 2 hours), 262 participants were required. Samples for copeptin and hs-cTnI assays were collected at presentation (0 hour) and after 2 hours. The measured biomarkers were considered abnormal when hs-cTnI was >26.2 ng/L and when copeptin was >10 pmol/L.

Results
AMI was diagnosed in 28 patients (10.7%). The NPV of the multi-marker strategy was 100% (160/160; 95% confidence interval [CI], 97.7% to 100%), which was not inferior to that of serial hs-cTnI measurements (201/201; 100%; 95% CI, 98.2% to 100%). The sensitivity, specificity, and positive predictive value of the multi-marker strategy were 100% (95% CI, 87.7% to 100%), 68.1% (95% CI, 61.7% to 74.0%), and 27.2% (95% CI, 18.9% to 36.8%), respectively. The sensitivity, specificity, and positive predictive value of serial hs-cTnI measurements were 100% (95% CI, 87.7% to 100%), 85.5% (95% CI, 80.4% to 89.8%), and 45.2% (95% CI, 32.5% to 58.3%), respectively.

Conclusion
The multi-marker strategy (copeptin and hs-cTnI measurement) was not inferior to serial hs-cTnI measurements in terms of NPV for AMI diagnosis, with a sensitivity and NPV of 100%. Copeptin may help in the early rule-out of AMI in patients with chest pain.

Citations

Citations to this article as recorded by  Crossref logo
  • Copeptin in Acute Myocardial Infarction: Is There a Role in the Era of High-Sensitivity Troponins?
    Sofia Bezati, Ioannis Ventoulis, Vasiliki Bistola, Christos Verras, Dionysis Matsiras, Effie Polyzogopoulou, John Parissis
    Journal of Cardiovascular Development and Disease.2025; 12(4): 144.     CrossRef
  • ATUALIZAÇÃO SOBRE OS BIOMARCADORES PRECOCES DO INFARTO AGUDO DO MIOCÁRDIO E SUAS RELAÇÕES COM A TROPONINA CARDÍACA: UMA REVISÃO DE LITERATURA
    Paula Rayssa Rodrigues, Gabriel Santiago De Faria, Alessandra Cristina Pupin Silvério
    RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218.2024; 5(8): e585497.     CrossRef
  • Copeptin plus troponin in the rapid rule out of acute myocardial infarction and prognostic value on post-myocardial infarction outcomes: a systematic review and diagnostic accuracy study
    Sheref A. Elseidy, Ahmed K. Awad, Debvarsha Mandal, Mounika Vorla, Ahmed Elkheshen, Tamam Mohamad
    Heart and Vessels.2023; 38(1): 1.     CrossRef
  • Copeptin with high-sensitivity cardiac troponin to rule out non-ST-elevation myocardial infarction early on: A systematic review and meta-analysis
    Danni Mu, Jian Zhong, Lei Li, Jin Cheng, Yutong Zou, Ling Qiu, Xinqi Cheng
    Clinical Biochemistry.2023; 112: 24.     CrossRef
  • Acute coronary syndrome as a current issue of pediatric cardiology. Outcomes and prognosis: Clinical case
    N. V. Tomchik, T. A. Lashkovskaya, A. I. Kizilevich, A. I. Matveichyk
    Kuban Scientific Medical Bulletin.2023; 30(5): 113.     CrossRef
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    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
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    Lukasz Szarpak, Marcin Lapinski, Aleksandra Gasecka, Michal Pruc, Wiktoria L. Drela, Mariusz Koda, Andrea Denegri, Frank W. Peacock, Miłosz J. Jaguszewski, Krzysztof J. Filipiak
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    Biomarkers.2020; 25(7): 539.     CrossRef
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  • 7 Web of Science
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Critical Care

Quick Sepsis-related Organ Failure Assessment score is not sensitive enough to predict 28-day mortality in emergency department patients with sepsis: a retrospective review
Kyung Su Kim, Gil Joon Suh, Kyuseok Kim, Woon Yong Kwon, Jonghwan Shin, You Hwan Jo, Jae Hyuk Lee, Huijai Lee
Clin Exp Emerg Med 2019;6(1):77-83.   Published online March 28, 2019
DOI: https://doi.org/10.15441/ceem.17.294

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Quick Sepsis-related Organ Failure Assessment score is not sensitive enough to predict 28-day mortality in emergency department patients with sepsis: a retrospective review
Clin Exp Emerg Med. 2019;6(1):77-83.   Published online March 28, 2019
DOI: https://doi.org/10.15441/ceem.17.294
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Quick Sepsis-related Organ Failure Assessment score is not sensitive enough to predict 28-day mortality in emergency department patients with sepsis: a retrospective review
Clin Exp Emerg Med. 2019;6(1):77-83.   Published online March 28, 2019
DOI: https://doi.org/10.15441/ceem.17.294
Close
Objective
To test the hypothesis that the quick Sepsis-related Organ Failure Assessment (qSOFA) score, derived from vital signs taken during triage and recommended by current sepsis guidelines for screening patients with infections for organ dysfunction, is not sensitive enough to predict the risk of mortality in emergency department (ED) sepsis patients.
Methods
Patients diagnosed with severe sepsis and septic shock using the old definition between May 2014 and April 2015 were retrospectively reviewed in three urban tertiary hospital EDs. The sensitivities of systemic inflammatory response syndrome (SIRS) criteria, qSOFA, and Sequential Organ Failure Assessment (SOFA) scores ≥2 were compared using McNemar’s test. Diagnostic performances were evaluated using specificity, positive predictive value, and negative predictive value.
Results
Among the 928 patients diagnosed with severe sepsis or septic shock using the old definition, 231 (24.9%) died within 28 days. More than half of the sepsis patients (493/928, 53.1%) and more than one-third of the mortality cases (88/231, 38.1%) had a qSOFA score <2. The sensitivity of a qSOFA score ≥2 was 61.9%, which was significantly lower than the sensitivity of SIRS ≥2 (82.7%, P<0.001) and SOFA ≥2 (99.1%, P<0.001). The specificity, positive predictive value, and negative predictive value of a qSOFA score ≥2 for 28-day mortality were 58.1%, 32.9%, and 82.2%, respectively.
Conclusion
The current clinical criteria of the qSOFA are less sensitive than the SIRS assessment and SOFA to predict 28-day mortality in ED patients with sepsis.

Citations

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    Victoria Castilho Bartolomeu, Luiz Humberto Vieri Piacezzi, Karina Aparecida Lopes da Costa, Ruth Ester Assayag Batista, Cássia Regina Vancini Campanharo, Maria Carolina Barbosa Teixeira Lopes
    Revista da Escola de Enfermagem da USP.2025;[Epub]     CrossRef
  • Evaluación del desempeño de puntajes de alerta temprana en pacientes con COVID-19
    Victoria Castilho Bartolomeu, Luiz Humberto Vieri Piacezzi, Karina Aparecida Lopes da Costa, Ruth Ester Assayag Batista, Cássia Regina Vancini Campanharo, Maria Carolina Barbosa Teixeira Lopes
    Revista da Escola de Enfermagem da USP.2025;[Epub]     CrossRef
  • Avaliação do desempenho dos escores de alerta precoce em pacientes com COVID-19
    Victoria Castilho Bartolomeu, Luiz Humberto Vieri Piacezzi, Karina Aparecida Lopes da Costa, Ruth Ester Assayag Batista, Cássia Regina Vancini Campanharo, Maria Carolina Barbosa Teixeira Lopes
    Revista da Escola de Enfermagem da USP.2025;[Epub]     CrossRef
  • C-reactive Protein/Albumin Ratio as a Predictive Inflammatory Marker for Postoperative Systemic Inflammatory Response Syndrome and/or Sepsis in Polytraumatized Patients in ICU
    Ahmed S Salem, Mohamed A Zaghloul, Alfred M Boctor, Mohamed Maher Abd Elfattah, Oliver M Shehata
    Indian Journal of Critical Care Medicine.2025; 29(12): 1002.     CrossRef
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    Batuhan Başpınar, Efe Cem Erdat, Ebru Ersoy Ortaç, Arzu Topeli
    Journal of Health Sciences and Medicine.2024; 7(1): 73.     CrossRef
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    Rahma Hellali, Zaineb Chelly Dagdia, Ahmed Ktaish, Karine Zeitouni, Djillali Annane
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    Venkat Reddy, Harshitha Reddy, Rinkle Gemnani, Sunil Kumar, Sourya Acharya
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    David F. Gaieski, Brendan Carr, Melanie Toolan, Kim Ciotti, Amy Kidane, Joseph Christina, Rajesh Aggarwal
    Telemedicine and e-Health.2023; 29(11): 1679.     CrossRef
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    Xia Qiu, Yu-Peng Lei, Rui-Xi Zhou
    Expert Review of Anti-infective Therapy.2023; 21(8): 891.     CrossRef
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    Athar Fekry Lasheen, Tarek Mohey Rageh, Mahmoud Magdy Al-Abassy, Ahmed Ragab Abdo Selima
    The Egyptian Journal of Surgery.2023; 42(3): 801.     CrossRef
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    Can Wang, Rufu Xu, Yuerong Zeng, Yu Zhao, Xuelian Hu, Ali Rostami
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    Heesu Park, Tae Gun Shin, Won Young Kim, You Hwan Jo, Yoon Jung Hwang, Sung-Hyuk Choi, Tae Ho Lim, Kap Su Han, Jonghwan Shin, Gil Joon Suh, Gu Hyun Kang, Kyung Su Kim
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    The American Journal of Emergency Medicine.2021; 44: 277.     CrossRef
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    Priya A Prasad, Margaret C Fang, Sandra P Martinez, Kathleen D Liu, Kirsten N Kangelaris
    Journal of Hospital Medicine.2021; 16(8): 453.     CrossRef
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    Dongze Li, Yisong Cheng, Jing Yu, Yu Jia, Bofu Liu, Yiqin Xia, Qin Zhang, Yanmei Liu, Yan Ma, Rong Yao, Zhi Zeng, Yu Cao, Shuyun Xu
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    Jong Eun Park, Sung Yeon Hwang, Ik Joon Jo, Min Seob Sim, Won Chul Cha, Hee Yoon, Tae Rim Kim, Gun Tak Lee, Hye Seung Kim, InSuk Sohn, Tae Gun Shin
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    Sarah M. Perman, Mark E. Mikkelsen, Munish Goyal, Adit Ginde, Abhishek Bhardwaj, Byron Drumheller, S. Cham Sante, Anish K. Agarwal, David F. Gaieski
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    Jia Ding, Yuwen Chen, Yuan Gao
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  • 19 Crossref

Resuscitation

Association between the simultaneous decrease in the levels of soluble vascular cell adhesion molecule-1 and S100 protein and good neurological outcomes in cardiac arrest survivors
Min-Jung Kim, Taegyun Kim, Gil Joon Suh, Woon Yong Kwon, Kyung Su Kim, Yoon Sun Jung, Jung-In Ko, So Mi Shin, A Reum Lee
Clin Exp Emerg Med 2018;5(4):211-218.   Published online December 31, 2018
DOI: https://doi.org/10.15441/ceem.17.267

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Association between the simultaneous decrease in the levels of soluble vascular cell adhesion molecule-1 and S100 protein and good neurological outcomes in cardiac arrest survivors
Clin Exp Emerg Med. 2018;5(4):211-218.   Published online December 31, 2018
DOI: https://doi.org/10.15441/ceem.17.267
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Association between the simultaneous decrease in the levels of soluble vascular cell adhesion molecule-1 and S100 protein and good neurological outcomes in cardiac arrest survivors
Clin Exp Emerg Med. 2018;5(4):211-218.   Published online December 31, 2018
DOI: https://doi.org/10.15441/ceem.17.267
Close
Objective
This study aimed to determine whether simultaneous decreases in the serum levels of cell adhesion molecules (intracellular cell adhesion molecule-1 [ICAM-1], vascular cell adhesion molecule-1 [VCAM-1], and E-selectin) and S100 proteins within the first 24 hours after the return of spontaneous circulation were associated with good neurological outcomes in cardiac arrest survivors.
Methods
This retrospective observational study was based on prospectively collected data from a single emergency intensive care unit (ICU). Twenty-nine out-of-hospital cardiac arrest survivors who were admitted to the ICU for post-resuscitation care were enrolled. Blood samples were collected at 0 and 24 hours after ICU admission. According to the 6-month cerebral performance category (CPC) scale, the patients were divided into good (CPC 1 and 2, n=12) and poor (CPC 3 to 5, n=17) outcome groups.
Results
No difference was observed between the two groups in terms of the serum levels of ICAM-1, VCAM-1, E-selectin, and S100 at 0 and 24 hours. A simultaneous decrease in the serum levels of VCAM-1 and S100 as well as E-selectin and S100 was associated with good neurological outcomes. When other variables were adjusted, a simultaneous decrease in the serum levels of VCAM-1 and S100 was independently associated with good neurological outcomes (odds ratio, 9.285; 95% confidence interval, 1.073 to 80.318; P=0.043).
Conclusion
A simultaneous decrease in the serum levels of soluble VCAM-1 and S100 within the first 24 hours after the return of spontaneous circulation was associated with a good neurological outcome in out-of-hospital cardiac arrest survivors.

Citations

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  • Inflammation and Neurological Outcomes in Cardiac Arrest – a Narrative Review of Serum Biomarker Investigations
    Sergio L. Angulo, Thomas W. Johnson, Lilly Hutchinson, Bhagyashri Bhende, Yama Akbari, Sung-Min Cho, Imad R. Khan
    Journal of Intensive Care Medicine.2025;[Epub]     CrossRef
  • Prognostic Value of Serum S100B Protein for Neurological Outcomes After Cardiac Arrest: A Systematic Review and Meta-Analysis
    Łukasz Szpinda, Michal Lis, Michal Pruc, Weronika Goraj, Iwona Niewiadomska, Maciej Maslyk, Katarzyna Kotfis, Hanno L. Tan, Enrico Baldi, Lukasz Szarpak
    Journal of Clinical Medicine.2025; 15(1): 238.     CrossRef
  • Recovery and Survival of Patients After Out-of-Hospital Cardiac Arrest: A Literature Review Showcasing the Big Picture of Intensive Care Unit-Related Factors
    Srdjan S Nikolovski, Aleksandra D Lazic, Zoran Z Fiser, Ivana A Obradovic, Jelena Z Tijanic, Violetta Raffay
    Cureus.2024;[Epub]     CrossRef
  • Predicting neurological outcome after out-of-hospital cardiac arrest with cumulative information; development and internal validation of an artificial neural network algorithm
    Peder Andersson, Jesper Johnsson, Ola Björnsson, Tobias Cronberg, Christian Hassager, Henrik Zetterberg, Pascal Stammet, Johan Undén, Jesper Kjaergaard, Hans Friberg, Kaj Blennow, Gisela Lilja, Matt P. Wise, Josef Dankiewicz, Niklas Nielsen, Attila Frigye
    Critical Care.2021;[Epub]     CrossRef
  • Regional cerebral oxygen saturation in cardiac arrest survivors undergoing targeted temperature management 36 °C versus 33 °C: A randomized clinical trial
    Woon Yong Kwon, Yoon Sun Jung, Gil Joon Suh, Taekyun Kim, Hyeongkyu Kwak, Taekwon Kim, Jeong Yeon Kim, Min Sung Lee, Kyung Su Kim, Jonghwan Shin, Hui Jai Lee, Kyung Min You
    Resuscitation.2021; 167: 362.     CrossRef
  • 9,164 View
  • 120 Download
  • 5 Web of Science
  • 5 Crossref
Admission levels of high-density lipoprotein and apolipoprotein A-1 are associated with the neurologic outcome in patients with out-of-hospital cardiac arrest
Yong Soo Son, Kyung Su Kim, Gil Joon Suh, Woon Yong Kwon, Min Ji Park, Jung In Ko, Taegyun Kim
Clin Exp Emerg Med 2017;4(4):232-237.   Published online December 30, 2017
DOI: https://doi.org/10.15441/ceem.16.164

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Admission levels of high-density lipoprotein and apolipoprotein A-1 are associated with the neurologic outcome in patients with out-of-hospital cardiac arrest
Clin Exp Emerg Med. 2017;4(4):232-237.   Published online December 30, 2017
DOI: https://doi.org/10.15441/ceem.16.164
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Admission levels of high-density lipoprotein and apolipoprotein A-1 are associated with the neurologic outcome in patients with out-of-hospital cardiac arrest
Clin Exp Emerg Med. 2017;4(4):232-237.   Published online December 30, 2017
DOI: https://doi.org/10.15441/ceem.16.164
Close
Objective
To investigate whether serum levels of high-density lipoprotein (HDL) and apolipoprotein A-1 (ApoA1), after the return of spontaneous circulation, can predict the neurologic outcome in patients with out-of-hospital cardiac arrest (OHCA).
Methods
This was a retrospective observational study conducted in a single tertiary hospital intensive care unit. All adult OHCA survivors with admission lipid profiles were enrolled from March 2013 to December 2015. Good neurologic outcome was defined as discharge cerebral performance categories 1 and 2.
Results
Among 59 patients enrolled, 13 (22.0%) had a good neurologic outcome. Serum levels of HDL (56.7 vs. 40 mg/dL) and ApoA1 (117 vs. 91.6 mg/dL) were significantly higher in patients with a good outcome. Areas under the HDL and ApoA1 receiver operating curves to predict good outcomes were 0.799 and 0.759, respectively. The proportion of good outcome was significantly higher in patients in higher tertiles of HDL and ApoA1 (test for trend, both P=0.003). HDL (P=0.018) was an independent predictor in the multivariate logistic regression model.
Conclusion
Admission levels of HDL and ApoA1 are associated with neurologic outcome in patients with OHCA. Prognostic and potential therapeutic values of HDL and ApoA1 merit further evaluation in the post-cardiac arrest state, as in other systemic inflammatory conditions such as sepsis.

Citations

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  • Total cholesterol and bilirubin levels are associated with neurologic outcomes in patients with out-of-hospital cardiac arrest
    Sang Hwan Lee, Yongil Cho, Jaehoon Oh, Hyunggoo Kang, Tae Ho Lim, Byuk Sung Ko, Kyung Hun Yoo, Juncheol Lee
    Internal and Emergency Medicine.2025; 20(4): 1185.     CrossRef
  • Neutrophil to high-density lipoprotein cholesterol ratio as a potential inflammatory marker for predicting all-cause mortality in out-of-hospital cardiac arrest survivors
    Da-Long Chen, Yu-Kai Lin, Guei-Jane Wang, Kuan-Cheng Chang
    Scientific Reports.2025;[Epub]     CrossRef
  • Lactate-to-albumin ratio and cholesterol levels predict neurological outcome in cardiac arrest survivors
    Da-Long Chen, Chia-Min Chung, Guei-Jane Wang, Kuan-Cheng Chang
    The American Journal of Emergency Medicine.2024; 83: 9.     CrossRef
  • Association between Early Phase Serum Albumin Levels and Outcomes of Post-Cardiac Arrest Patients: A Systematic Review and Meta-Analysis
    Heekyung Lee, Juncheol Lee, Hyungoo Shin, Tae-Ho Lim, Bo-Hyoung Jang, Youngsuk Cho, Wonhee Kim, Jae-Guk Kim, Kyu-Sun Choi, Min-Kyun Na, Chiwon Ahn, Sae-Min Kwon
    Journal of Personalized Medicine.2022; 12(11): 1787.     CrossRef
  • Serum total cholesterol level as a potential predictive biomarker for neurological outcomes in cardiac arrest survivors who underwent target temperature management
    Changjoo Ahn, Changshin Kang, Hong Joon Ahn, Yeonho You, Jung Soo Park, Jin Hong Min, Wonjoon Jeong, Yongchul Cho, Seung Ryu, Yong Nam In
    Medicine.2022; 101(46): e31909.     CrossRef
  • Persistence of Lipoproteins and Cholesterol Alterations after Sepsis: Implication for Atherosclerosis Progression
    Krzysztof Laudanski
    International Journal of Molecular Sciences.2021; 22(19): 10517.     CrossRef
  • Low serum cholesterol level as a risk factor for out-of-hospital cardiac arrest: a case-control study
    Jae Kwang Yang, Yu Jin Kim, Joo Jeong, Jungeun Kim, Jeong Ho Park, Young Sun Ro, Sang Do Shin
    Clinical and Experimental Emergency Medicine.2021; 8(4): 296.     CrossRef
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    Minjung Kathy Chae, Sung Eun Lee, Young Gi Min, Eun Jung Park
    Resuscitation.2020; 146: 50.     CrossRef
  • The association between lipid profiles and the neurologic outcome in patients with out-of-hospital cardiac arrest
    Hyoung Youn Lee, Dong Hun Lee, Byung Kook Lee, Kyung Woon Jeung, Yong Hun Jung, Jung Soo Park, Jin Hong Min, Yong Il Min
    Resuscitation.2019; 145: 26.     CrossRef
  • 9,808 View
  • 180 Download
  • 9 Web of Science
  • 9 Crossref

Critical Care

Korean Shock Society septic shock registry: a preliminary report
Tae Gun Shin, Sung Yeon Hwang, Gu Hyun Kang, Won Young Kim, Seung Mok Ryoo, Kyuseok Kim, You Hwan Jo, Sung Phil Chung, Young Seon Joo, Jin Ho Beom, Sung-Hyuk Choi, Young Hoon Yoon, Woon Yong Kwon, Tae Ho Lim, Kap Su Han, Han Sung Choi, Gil Joon Suh
Clin Exp Emerg Med 2017;4(3):146-153.   Published online September 30, 2017
DOI: https://doi.org/10.15441/ceem.17.204

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Korean Shock Society septic shock registry: a preliminary report
Clin Exp Emerg Med. 2017;4(3):146-153.   Published online September 30, 2017
DOI: https://doi.org/10.15441/ceem.17.204
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Korean Shock Society septic shock registry: a preliminary report
Clin Exp Emerg Med. 2017;4(3):146-153.   Published online September 30, 2017
DOI: https://doi.org/10.15441/ceem.17.204
Close
Objective
To evaluate the clinical characteristics, therapeutic interventions, and outcomes of patients with septic shock admitted to the emergency department (ED). Methods This study was a preliminary, descriptive analysis of a prospective, multi-center, observational registry of the EDs of 10 hospitals participating in the Korean Shock Society. Patients aged 19 years or older who had a suspected or confirmed infection and evidence of refractory hypotension or hypoperfusion were included. Results A total of 468 patients were enrolled (median age, 71.3 years; male, 55.1%; refractory hypotension, 82.9%; hyperlactatemia without hypotension, 17.1%). Respiratory infection was the most common source of infection (31.0%). The median Sepsis-related Organ Failure Assessment score was 7.5. The sepsis bundle compliance was 91.2% for lactate measurement, 70.3% for blood culture, 68.4% for antibiotic administration, 80.3% for fluid resuscitation, 97.8% for vasopressor application, 68.0% for central venous pressure measurement, 22.0% for central venous oxygen saturation measurement, and 59.2% for repeated lactate measurement. Among patients who underwent interventions for source control (n=117, 25.1%), 43 (36.8%) received interventions within 12 hours of ED arrival. The in-hospital, 28-day, and 90-day mortality rates were 22.9%, 21.8%, and 27.1%, respectively. The median ED and hospital lengths of stay were 6.8 hours and 12 days, respectively. Conclusion This preliminary report revealed a mortality of over 20% in patients with septic shock, which suggests that there are areas for improvement in terms of the quality of initial resuscitation and outcomes of septic shock patients in the ED.

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    Kyung Hun Yoo, Gil Joon Suh, Woon Yong Kwon, Sung-Hyuk Choi, Sung Phil Chung, Won Young Kim, Kyuseok Kim, Yoo Seok Park, Tae Gun Shin, Byuk Sung Ko, Tae Ho Lim, Yongil Cho
    Journal of Korean Medical Science.2026;[Epub]     CrossRef
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    Chaeeun Lee, Gil Joon Suh, Sung-Hyuk Choi, Sung Phil Chung, Won Young Kim, Tae Ho Lim, Sangchun Choi, Tae Gun Shin, Sangun Nah, Sangsoo Han
    European Journal of Emergency Medicine.2026;[Epub]     CrossRef
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    Sangun Nah, Tae Ho Lim, Sung Phil Chung, Gil Joon Suh, Sung-Hyuk Choi, Woon Yong Kwon, Won Young Kim, Kyuseok Kim, Sangchun Choi, Je Sung You, Han Sung Choi, Tae Gun Shin, Sangsoo Han
    BMC Emergency Medicine.2026;[Epub]     CrossRef
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    Lichang Sun, Cong Zhang, Ping Song, Xiaoni Zhong, Biao Xie, Yingzhu Huang, Yuanjia Hu, Ximing Xu, Xun Lei
    Heart & Lung.2025; 70: 147.     CrossRef
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    Ji Han Heo, Taegyun Kim, Tae Gun Shin, Gil Joon Suh, Woon Yong Kwon, Hayoung Kim, Heesu Park, Heejun Kim, Sol Han
    Acute and Critical Care.2025; 40(2): 221.     CrossRef
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    Sungwoo Choi, Sangun Nah, Gil Joon Suh, Sung-Hyuk Choi, Sung Phil Chung, Won Young Kim, Tae Ho Lim, Sangchun Choi, Tae Gun Shin, Sangsoo Han
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    Fariba Shabani, Seyedeh Narjes Ahmadizadeh, Shahabedin Rahmatizadeh, Seyedeh Masumeh Hashemi, Reza Rabiei, Azita Behzad
    Health Science Reports.2025;[Epub]     CrossRef
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    Kyung Hun Yoo, Sung-Hyuk Choi, Gil Joon Suh, Sung Phil Chung, Han Sung Choi, Yoo Seok Park, You Hwan Jo, Tae Gun Shin, Tae Ho Lim, Won Young Kim, Juncheol Lee
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    Sejoong Ahn, Bo-Yeong Jin, Sukyo Lee, Sungjin Kim, Sungwoo Moon, Hanjin Cho, Kap Su Han, You Hwan Jo, Kyuseok Kim, Jonghwan Shin, Gil Joon Suh, Woon Yong Kwon, Tae Gun Shin, Han Sung Choi, Sangchun Choi, Yoo Seok Park, Sung Phil Chung, Won Young Kim, Hong
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    Ling Yan Leung, Hsi-Lan Huang, Kevin KC Hung, Chi Yan Leung, Cherry CY Lam, Ronson SL Lo, Chun Yu Yeung, Peter Joseph Tsoi, Michael Lai, Mikkel Brabrand, Joseph H Walline, Colin A Graham
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    Sungjin Kim, Sukyo Lee, Sejoong Ahn, Jonghak Park, Sungwoo Moon, Hanjin Cho, Sung-Hyuk Choi
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    Myeong Namgung, Chiwon Ahn, Yeonkyung Park, Il-Youp Kwak, Jungguk Lee, Moonho Won
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    Heesu Park, Tae Gun Shin, Won Young Kim, You Hwan Jo, Yoon Jung Hwang, Sung-Hyuk Choi, Tae Ho Lim, Kap Su Han, Jonghwan Shin, Gil Joon Suh, Gu Hyun Kang, Kyung Su Kim
    Clinical and Experimental Emergency Medicine.2022; 9(2): 84.     CrossRef
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    Biomedicines.2022; 10(9): 2090.     CrossRef
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    Journal of Clinical Medicine.2022; 11(23): 7231.     CrossRef
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    Jong Eun Park, Gun Tak Lee, Jiyeong Lee, Young-Min Kim, Tae Gun Shin, Se Uk Lee, Taerim Kim, Hee Yoon, Won Chul Cha, Sung Yeon Hwang
    The American Journal of Emergency Medicine.2021; 46: 430.     CrossRef
  • Characteristics and clinical outcomes of culture-negative and culture-positive septic shock: a single-center retrospective cohort study
    June-sung Kim, Youn-Jung Kim, Won Young Kim
    Critical Care.2021;[Epub]     CrossRef
  • Short and Long-Term Mortality Trends for Cancer Patients with Septic Shock Stratified by Cancer Type from 2009 to 2017: A Population-Based Cohort Study
    Youn-Jung Kim, Min-Ju Kim, Ye-Jee Kim, Won Young Kim
    Cancers.2021; 13(4): 657.     CrossRef
  • Pulse pressure during the initial resuscitative period in patients with septic shock treated with a protocol-driven resuscitation bundle therapy
    Sang-Hun Lee, Youn-Jung Kim, Gi Na Yu, Jae Cheon Jeon, Won Young Kim
    The Korean Journal of Internal Medicine.2021; 36(4): 924.     CrossRef
  • Effect of rapid fluid administration on the prognosis of septic shock patients with isolated hyperlactatemia: A prospective multicenter observational study
    Heekyung Lee, Sung-Hyuk Choi, Kyuseok Kim, Tae Gun Shin, Yoo Seok Park, Seung Mok Ryoo, Gil Joon Suh, Woon Yong Kwon, Tae Ho Lim, Donghee Son, Won Young Kim, Byuk Sung Ko
    Journal of Critical Care.2021; 66: 154.     CrossRef
  • Impact of Vitamin C and Thiamine Administration on Delirium-Free Days in Patients with Septic Shock
    Jong Eun Park, Tae Gun Shin, Ik Joon Jo, Kyeongman Jeon, Gee Young Suh, Minsu Park, Hojeong Won, Chi Ryang Chung, Sung Yeon Hwang
    Journal of Clinical Medicine.2020; 9(1): 193.     CrossRef
  • Korean Registry for Improving Sepsis Survival (KISS): Protocol for a Multicenter Cohort of Adult Patients with Sepsis or Septic Shock
    Jong Hun Kim, Nam Su Ku, Youn Jeong Kim, Hong Bin Kim, Hyeri Seok, Dong-Gun Lee, Jin Seo Lee, Su Jin Jeong, Jung-Hyun Choi, Jang Wook Sohn, Min Ja Kim, Dae Won Park
    Infection & Chemotherapy.2020; 52(1): 31.     CrossRef
  • Normothermia in Patients With Sepsis Who Present to Emergency Departments Is Associated With Low Compliance With Sepsis Bundles and Increased In-Hospital Mortality Rate*
    Sunghoon Park, Kyeongman Jeon, Dong Kyu Oh, Eun Young Choi, Gil Myeong Seong, Jeongwon Heo, Youjin Chang, Won Gun Kwack, Byung Ju Kang, Won-Il Choi, Kyung Chan Kim, So Young Park, Yoon Mi Shin, Heung Bum Lee, So Hee Park, Seok Chan Kim, Sang Hyun Kwak, Ja
    Critical Care Medicine.2020; 48(10): 1462.     CrossRef
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    The American Journal of Emergency Medicine.2019; 37(6): 1054.     CrossRef
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    Journal of Clinical Medicine.2019; 8(1): 102.     CrossRef
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    Hongjung Kim, Sung Phil Chung, Sung-Hyuk Choi, Gu Hyun Kang, Tae Gun Shin, Kyuseok Kim, Yoo Seok Park, Kap Su Han, Han Sung Choi, Gil Joon Suh, Won Young Kim, Tae Ho Lim, Byuk Sung Ko
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    Hyeri Seok, Dae Won Park
    Journal of the Korean Medical Association.2019; 62(12): 638.     CrossRef
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    Byuk Sung Ko, Kyuseok Kim, Sung-Hyuk Choi, Gu Hyun Kang, Tae Gun Shin, You Hwan Jo, Seung Mok Ryoo, Jin Ho Beom, Woon Yong Kwon, Kap Su Han, Han Sung Choi, Sung Phil Chung, Gil Joon Suh, Tae Ho Lim, Won Young Kim
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    Journal of Trauma and Injury.2018; 31(3): 166.     CrossRef
  • 13,081 View
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  • 30 Web of Science
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Imaging | Gastrointestinal

Diagnostic accuracy and implementation of computed tomography angiography for gastrointestinal hemorrhage according to clinical severity
Yoo Jin Choi, Kyung Su Kim, Gil Joon Suh, Woon Yong Kwon
Clin Exp Emerg Med 2016;3(2):69-74.   Published online June 30, 2016
DOI: https://doi.org/10.15441/ceem.15.066

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Diagnostic accuracy and implementation of computed tomography angiography for gastrointestinal hemorrhage according to clinical severity
Clin Exp Emerg Med. 2016;3(2):69-74.   Published online June 30, 2016
DOI: https://doi.org/10.15441/ceem.15.066
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Diagnostic accuracy and implementation of computed tomography angiography for gastrointestinal hemorrhage according to clinical severity
Clin Exp Emerg Med. 2016;3(2):69-74.   Published online June 30, 2016
DOI: https://doi.org/10.15441/ceem.15.066
Close
Objective
This study compared the diagnostic accuracy of computed tomography (CT) angiography in patients with various severities of gastrointestinal hemorrhage (GIH).
Methods
We retrospectively enrolled adult patients (n=262) with GIH who had undergone CT angiography from January 2012 to December 2013. Age, sex, comorbidities, presenting symptoms, initial vital signs, laboratory results, transfusion volume, emergency department disposition, and hospital mortality were abstracted from patient records. CT angiography findings were reviewed and compared to reference standards consisting of endoscopy, conventional angiography, bleeding scan, capsule endoscopy, and surgery, either alone or in combination. Clinical severity was stratified according to the number of packed red blood cell units transfused during the first two days: the first quartile was categorized as mild severity, while the second and third quartiles were categorized as moderate severity. The fourth quartile was categorized as severe.
Results
Patients were categorized into the mild (n=75, 28.6%), moderate (n=139, 53.1%), and severe (n=48, 18.3%) groups. The mean number of transfused packed red blood cell units was 0, 3, and 9.6 in the mild, moderate, and severe groups, respectively. The overall sensitivity, specificity, positive predictive value, and negative predictive value of CT angiography were 73.8%, 94.0%, 97.3%, and 55.3%, respectively. The area under the receiver operating characteristics curve for the diagnostic performance of CT angiography was 0.780, 0.841, and 0.930 in the mild, moderate, and severe groups, respectively, which significantly differed among groups (P=0.006).
Conclusion
The diagnostic accuracy of CT angiography is better in patients with more severe GIH.

Citations

Citations to this article as recorded by  Crossref logo
  • The Accuracy of Computed Tomography Angiography Compared With Technetium-99m Labelled Red Blood Cell Scintigraphy for the Diagnosis and Localization of Acute Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis
    Kaspar L. Yaxley, Ali Mulhem, Sean Godfrey, Jason L. Oke
    Current Problems in Diagnostic Radiology.2023; 52(6): 546.     CrossRef
  • Delayed endoscopy is associated with increased mortality in upper gastrointestinal hemorrhage
    Namkyung Jeong, Kyung Su Kim, Yoon Sun Jung, Taegyun Kim, So Mi Shin
    The American Journal of Emergency Medicine.2019; 37(2): 277.     CrossRef
  • Comparison of the National Early Warning Score+Lactate score with the pre-endoscopic Rockall, Glasgow-Blatchford, and AIMS65 scores in patients with upper gastrointestinal bleeding
    Daejin Kim, Sion Jo, Jae Baek Lee, Youngho Jin, Taeoh Jeong, Jaechol Yoon, Boyoung Park
    Clinical and Experimental Emergency Medicine.2018; 5(4): 219.     CrossRef
  • 17,419 View
  • 106 Download
  • 4 Web of Science
  • 3 Crossref

Resuscitation

Outcome and current status of therapeutic hypothermia after out-of-hospital cardiac arrest in Korea using data from the Korea Hypothermia Network registry
Byung Kook Lee, Kyu Nam Park, Gu Hyun Kang, Kyung Hwan Kim, Giwoon Kim, Won Young Kim, Jin Hong Min, Yooseok Park, Jung Bae Park, Gil Joon Suh, Yoo Dong Son, Jonghwan Shin, Joo Suk Oh, Yeon Ho You, Dong Hoon Lee, Jong Seok Lee, Hoon Lim, Tae Chang Jang, Gyu Chong Cho, In Soo Cho, Kyoung Chul Cha, Seung Pill Choi, Wook Jin Choi, Chul Han, The Korean Hypothermia Network Investigators
Clin Exp Emerg Med 2014;1(1):19-27.   Published online September 30, 2014
DOI: https://doi.org/10.15441/ceem.14.007

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Outcome and current status of therapeutic hypothermia after out-of-hospital cardiac arrest in Korea using data from the Korea Hypothermia Network registry
Clin Exp Emerg Med. 2014;1(1):19-27.   Published online September 30, 2014
DOI: https://doi.org/10.15441/ceem.14.007
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Outcome and current status of therapeutic hypothermia after out-of-hospital cardiac arrest in Korea using data from the Korea Hypothermia Network registry
Clin Exp Emerg Med. 2014;1(1):19-27.   Published online September 30, 2014
DOI: https://doi.org/10.15441/ceem.14.007
Close
Objective

Therapeutic hypothermia (TH) has become the standard strategy for reducing brain damage in the postresuscitation period. The aim of this study was to investigate current TH performance and outcomes in out-of-hospital cardiac arrest (OHCA) survivors using data from the Korean Hypothermia Network (KORHN) registry.

 Methods

We used the KORHN registry, a web-based multicenter registry that includes 24 participating hospitals throughout the Republic of Korea. Adult comatose OHCA survivors treated with TH between 2007 and 2012 were included. The primary outcomes were neurological outcome at hospital discharge and in-hospital mortality. The secondary outcomes were TH performance and adverse events during TH.

 Results

A total of 930 patients were included, of whom 556 (59.8%) survived to discharge and 249 (26.8%) were discharged with good neurologic outcomes. The median time from return of spontaneous circulation (ROSC) to the start of TH was 101 minutes (interquartile range [IQR], 46 to 200 minutes). The induction, maintenance, and rewarming durations were 150 minutes (IQR, 80 to 267 minutes), 1,440 minutes (IQR, 1,290 to 1,440 minutes), and 708 minutes (IQR, 420 to 900 minutes), respectively. The time from the ROSC to coronary angiography was 1,045 hours (IQR, 121 to 12,051 hours). Hyperglycemia (46.3%) was the most frequent adverse event.

 Conclusion

More than one-quarter of the OHCA survivors (26.8%) were discharged with good neurologic outcomes. TH performance was appropriately managed in terms of the factors related to its timing, including cooling start time and rewarming duration.

Citations

Citations to this article as recorded by  Crossref logo
  • Association Between the Timing of Coronary Angiography, Targeted Temperature Management, and Neurological Outcomes After Out‐of‐Hospital Cardiac Arrest: A Nationwide Population‐Based Registry Study in Korea
    Sang Hoon Oh, Han Joon Kim, Kyu Nam Park, Chun Song Youn, Jee Yong Lim, Hyo Joon Kim, Hyo Jin Bang
    Journal of the American Heart Association.2025;[Epub]     CrossRef
  • Feasibility of Magnetic Resonance-Based Conductivity Imaging as a Tool to Estimate the Severity of Hypoxic-Ischemic Brain Injury in the First Hours After Cardiac Arrest
    Yong Hun Jung, Hyoung Youn Lee, Byung Kook Lee, Bup Kyung Choi, Tae-Hoon Kim, Jin Woong Kim, Hyun Chul Kim, Hyung Joong Kim, Kyung Woon Jeung
    Neurocritical Care.2024; 40(2): 538.     CrossRef
  • Brain Death and Its Prediction in Out-of-Hospital Cardiac Arrest Patients Treated with Targeted Temperature Management
    Hwan Song, Sang Hoon Oh, Hye Rim Woo
    Diagnostics.2022; 12(5): 1190.     CrossRef
  • Ultra-early neurologic outcome prediction of out-of-hospital cardiac arrest survivors using combined diffusion-weighted imaging findings and quantitative analysis of apparent diffusion coefficient
    Jung Soo Park, Yong Nam In, Yeon Ho You, Jin Hong Min, Hong Joon Ahn, In Sool Yoo, Seung Whan Kim, Jin Woong Lee, Seung Ryu, Won Joon Jeong, Yong Chul Cho, Se Kwang Oh, Sung Uk Cho, Chang Shin Kang, In Ho Lee, Byung Kook Lee, Dong Hun Lee, Dong Hoon Lee
    Resuscitation.2020; 148: 39.     CrossRef
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    Wan Jing Tay, Huihua Li, Andrew FW Ho, Ching Hui Sia, Georgina GJ Kwek, Sohil Pothiawala, Nur Shahidah, Kenneth BK Tan, Aaron SL Aaron SL Wong, Duu Wen Sewa, Eric TS Lim, Chee Tang Chin, Marcus EH Marcus EH Ong
    Annals of the Academy of Medicine, Singapore.2020; 49(3): 127.     CrossRef
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    Soo Hyun Kim, Kyu Nam Park, Chun Song Youn, Minjung Kathy Chae, Won Young Kim, Byung Kook Lee, Dong Hoon Lee, Tae Chang Jang, Jae Hoon Lee, Yoon Hee Choi, Je Sung You, In Soo Cho, Su Jin Kim, Jong-Seok Lee, Yong Hwan Kim, Min Seob Sim, Jonghwan Shin, Yoo
    Clinical and Experimental Emergency Medicine.2020; 7(4): 250.     CrossRef
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    Seung Mok Ryoo, Seung Joon Yoo, Joon Sung Kim, Gina Yu, Sungmin Jung, Youn-Jung Kim, Chang Hwan Sohn, Won Young Kim
    Therapeutic Hypothermia and Temperature Management.2019; 9(3): 190.     CrossRef
  • Recovery from acute kidney injury as a potent predictor of survival and good neurological outcome at discharge after out-of-hospital cardiac arrest
    Yoo Seok Park, Yoon Hee Choi, Je Hyeok Oh, In Soo Cho, Kyoung-Chul Cha, Byung-Sun Choi, Je Sung You
    Critical Care.2019;[Epub]     CrossRef
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    Je Hyeok Oh, Dong Hoon Lee, In Soo Cho, Chun Song Youn, Byung Kook Lee, Jung Hee Wee, Kyoung-Chul Cha, Minjung Kathy Chae, Jonghwan Shin
    Journal of Critical Care.2019; 54: 197.     CrossRef
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    Seung Mok Ryoo, Dong Hun Lee, Byung Kook Lee, Chun Song Youn, Youn-Jung Kim, Su Jin Kim, Yong Hwan Kim, Won Young Kim
    Journal of Clinical Medicine.2019; 8(9): 1360.     CrossRef
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    Hyung Ki Moon, Jinhee Jang, Kyu Nam Park, Soo Hyun Kim, Byung Kook Lee, Sang Hoon Oh, Kyung Woon Jeung, Seung Pill Choi, In Soo Cho, Chun Song Youn
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    Dong Hoon Lee, Sun Hwa Lee, Je Hyeok Oh, In Soo Cho, Young Hwan Lee, Chul Han, Wook Jin Choi, You Dong Sohn
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    Jeong Ho Park, Jae Hun Oh, Seung Pill Choi, Jung Hee Wee
    Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine.2018;[Epub]     CrossRef
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    Byung Kook Lee, In Soo Cho, Joo Suk Oh, Wook Jin Choi, Jung Hee Wee, Chang Sun Kim, Won Young Kim, Chun Song Youn, Salvatore De Rosa
    PLOS ONE.2018; 13(12): e0209327.     CrossRef
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    Yong Hun Jung, Byung Kook Lee, Dong Hun Lee, Sung Min Lee, Yong Soo Cho, Kyung Woon Jeung
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    Byung Kook Lee, Won Young Kim, Jonghwan Shin, Joo Suk Oh, Jung Hee Wee, Kyoung Chul Cha, Yooseok Park, Jae Hyung Choi, Kyung Woon Jeung
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    Byoung-Joon Oh, Yong-Gyun Im, Eunjung Park, Young-Gi Min, Sang-Cheon Choi
    Clinical and Experimental Emergency Medicine.2016; 3(2): 100.     CrossRef
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    Young-Min Kim, Chun Song Youn, Soo Hyun Kim, Byung Kook Lee, In Soo Cho, Gyu Chong Cho, Kyung Woon Jeung, Sang Hoon Oh, Seung Pill Choi, Jong Hwan Shin, Kyoung-Chul Cha, Joo Suk Oh, Hyeon Woo Yim, Kyu Nam Park
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    Byung Kook Lee, Kyung Woon Jeung, Kyoung Hwan Song, Yong Hun Jung, Wook Jin Choi, Soo Hyun Kim, Chun Sung Youn, In Soo Cho, Dong Hun Lee
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  • Continuous Amplitude-Integrated Electroencephalographic Monitoring Is a Useful Prognostic Tool for Hypothermia-Treated Cardiac Arrest Patients
    Sang Hoon Oh, Kyu Nam Park, Young-Min Shon, Young-Min Kim, Han Joon Kim, Chun Song Youn, Soo Hyun Kim, Seung Pill Choi, Seok Chan Kim
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  • 18,614 View
  • 190 Download
  • 21 Web of Science
  • 23 Crossref
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CEEM : Clinical and Experimental Emergency Medicine