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"Hoon Kim"

Original Articles

Experimental study | Trauma

The long-term influences of age at injury on neuroinflammation and neuronal apoptosis following traumatic brain injury in pediatric and adult mice
Jin-Soo Park, Hyun-Jeong Park, Young-Min Kim, Hyun-Seok Chai, Gwan Jin Park, Sang-Chul Kim, Gyeong-Gyu Yu, Suk-Woo Lee, Hoon Kim
Clin Exp Emerg Med 2025;12(3):267-279.   Published online January 14, 2025
DOI: https://doi.org/10.15441/ceem.24.266

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The long-term influences of age at injury on neuroinflammation and neuronal apoptosis following traumatic brain injury in pediatric and adult mice
Clin Exp Emerg Med. 2025;12(3):267-279.   Published online January 14, 2025
DOI: https://doi.org/10.15441/ceem.24.266
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The long-term influences of age at injury on neuroinflammation and neuronal apoptosis following traumatic brain injury in pediatric and adult mice
Clin Exp Emerg Med. 2025;12(3):267-279.   Published online January 14, 2025
DOI: https://doi.org/10.15441/ceem.24.266
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Objective
The study explores the long-term impacts of traumatic brain injury (TBI) on neuroinflammation and neuronal apoptosis in pediatric and adult mice, focusing on how age at injury influences these processes.
Methods
Controlled cortical impacts were used to induce TBI in pediatric (21–25 days old) and adult (8–12 weeks old) C57BL/6 male mice. Neuroinflammation was evaluated by measuring immunoreactivity for allograft inflammatory factor 1 (AIF-1)/ionized calcium-binding adaptor molecule 1 (Iba-1) and glial fibrillary acidic protein (GFAP), while apoptosis was assessed using markers such as B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax), Bcl-2, and procaspase-3. Additionally, heat shock protein 70 (HSP70) expression was measured to understand the stress response.
Results
Following controlled cortical impacts, pediatric mice exhibited a significant reduction in expression of neuronal nuclei (P<0.001), and significant increases in expression of GFAP (P<0.01) and AIF-1/Iba-1 (P<0.05) at 3 days post-injury (DPI) compared with sham controls. In contrast, adult mice exhibited no significant change in AIF-1/Iba-1 expression and a less pronounced increase in GFAP (P<0.05) at 3 DPI compared with sham controls. A more significant increase in Bax/Bcl-2 ratio at 7 DPI (P<0.01) was seen in pediatric mice, while a weak but significant increase in Bax/Bcl-2 ratio at 7 DPI (P<0.05) was evident in adults. Both age groups showed a significant but transient increase in HSP70 levels at 7 DPI, which normalized by 90 DPI.
Conclusion
Pediatric and adult mice exhibited significant time-dependent differences in neuroinflammation and apoptosis following TBI, with pediatric mice showing more intense early responses indicative of age-specific vulnerabilities in post-injury outcomes. Both age groups showed a significant but transient increase in HSP70 expression, suggesting an acute response to stress post-injury.

Citations

Citations to this article as recorded by  Crossref logo
  • Extracellular vesicles as biomarkers for traumatic brain injury using a 3D in vitro human brain tissue model
    Peter Hsi, Vishal Tandon, David L. Kaplan
    Scientific Reports.2025;[Epub]     CrossRef
  • 4,814 View
  • 70 Download
  • 1 Web of Science
  • 1 Crossref

Airway | Critical Care

Development and demonstration of the protective efficacy of a convertible respiratory barrier enclosure: a simulation study
Min Ho Park, Ki Sub Sung, Ji Hoon Kim, Jinwoo Myung, Ju Young Hong
Clin Exp Emerg Med 2024;11(1):59-67.   Published online November 29, 2023
DOI: https://doi.org/10.15441/ceem.23.067

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Development and demonstration of the protective efficacy of a convertible respiratory barrier enclosure: a simulation study
Clin Exp Emerg Med. 2024;11(1):59-67.   Published online November 29, 2023
DOI: https://doi.org/10.15441/ceem.23.067
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Development and demonstration of the protective efficacy of a convertible respiratory barrier enclosure: a simulation study
Clin Exp Emerg Med. 2024;11(1):59-67.   Published online November 29, 2023
DOI: https://doi.org/10.15441/ceem.23.067
Close
Objective
The efficacy of previously developed respiratory barrier enclosures to limit healthcare workers’ exposure to aerosols from COVID-19 patients remains unclear; in addition, the design of these devices is unsuitable for transportation or other emergency procedures. Therefore, we developed a novel negative pressure respiratory isolator to improve protection from patient-generated aerosols and evaluated its protective effect in conversion to systemic isolator. Methods This in vitro study simulated droplets by nebulizing 1% glycerol + 99% ethanol solution. We performed cardiopulmonary resuscitation (CPR) and converted a respiratory barrier enclosure into a systemic isolator with a respiratory barrier as well as a respiratory barrier with negative pressure generator (NPG), which were compared with control and room air. During the procedure, particles were counted for 30 seconds and the count was repeated 10 times. Results During CPR, the total number of particles in the respiratory barrier with NPG (280,529; interquartile range [IQR], 205,263–359,195; P=0.970) was similar to that in the control (308,789; IQR, 175,056–473,276). Using NPG with a respiratory barrier reduced the number of particles to 27,524 (IQR, 26,703– 28,905; P=0.001). Particle number during conversion of the respiratory barrier into a systemic isolator was also lower than in the control (25,845; IQR, 19,391– 29,772; P=0.001). Conclusion The novel isolator was converted to a systemic isolator without air leakage. The aerosol-blocking effect of the isolator was quantified using a particle counter during CPR. Further studies comparing the barrier effect of isolators within various pressure differentials are warranted.

Citations

Citations to this article as recorded by  Crossref logo
  • A New Method Proposed for Analyzing Airflow Dynamics in Negative Pressure Isolation Chambers Using Particle Image Velocimetry
    Min Jae Oh, Jung Min Moon, Seung Cheol Ko, Min Ji Kim, Ki Sub Sung, Jung Woo Lee, Ju Young Hong, Joon Sang Lee, Yong Hyun Kim
    Bioengineering.2025; 12(3): 302.     CrossRef
  • Enhanced Aerosol Containment Performance of a Negative Pressure Hood with an Aerodynamic Cap Design: Multi-Method Validation Using CFD, PAO Particles, and Microbial Testing
    Seungcheol Ko, Kisub Sung, Min Jae Oh, Yoonjic Kim, Min Ji Kim, Jung Woo Lee, Yoo Seok Park, Yong Hyun Kim, Ju Young Hong, Joon Sang Lee
    Bioengineering.2025; 12(6): 624.     CrossRef
  • Enhancing Aerosol Mitigation in Medical Procedures: A CFD-Informed Respiratory Barrier Enclosure
    Ju Young Hong, Seungcheol Ko, Ki Sub Sung, Min Jae Oh, Min Ji Kim, Jung Woo Lee, Yoo Seok Park, Yong Hyun Kim, Joon Sang Lee
    Bioengineering.2024; 11(11): 1104.     CrossRef
  • 7,176 View
  • 91 Download
  • 3 Web of Science
  • 3 Crossref

Editorial

Emergency Medical Services | AI & Digital Health

Data integration using information and communication technology for emergency medical services and systems
Ji Hoon Kim
Clin Exp Emerg Med 2023;10(2):129-131.   Published online February 24, 2023
DOI: https://doi.org/10.15441/ceem.23.003

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Data integration using information and communication technology for emergency medical services and systems
Clin Exp Emerg Med. 2023;10(2):129-131.   Published online February 24, 2023
DOI: https://doi.org/10.15441/ceem.23.003
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Data integration using information and communication technology for emergency medical services and systems
Clin Exp Emerg Med. 2023;10(2):129-131.   Published online February 24, 2023
DOI: https://doi.org/10.15441/ceem.23.003
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Citations

Citations to this article as recorded by  Crossref logo
  • Development of AI-Based Prediction of Heart Attack Risk as an Element of Preventive Medicine
    Izabela Rojek, Piotr Kotlarz, Mirosław Kozielski, Mieczysław Jagodziński, Zbyszko Królikowski
    Electronics.2024; 13(2): 272.     CrossRef
  • Clinical Research in Prehospital Care: Current and Future Challenges
    Jonathan Cimino, Claude Braun
    Clinics and Practice.2023; 13(5): 1266.     CrossRef
  • 5,798 View
  • 125 Download
  • 3 Web of Science
  • 2 Crossref

Original Articles

Experimental study

Chronic juvenile stress exacerbates neurobehavioral dysfunction and neuroinflammation following traumatic brain injury in adult mice
Sung-Jin Park, Hyun-Jeong Park, Backyoun Kim, Young-Min Kim, Suk-Woo Lee, Hoon Kim
Clin Exp Emerg Med 2023;10(2):200-212.   Published online February 14, 2023
DOI: https://doi.org/10.15441/ceem.22.377

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Chronic juvenile stress exacerbates neurobehavioral dysfunction and neuroinflammation following traumatic brain injury in adult mice
Clin Exp Emerg Med. 2023;10(2):200-212.   Published online February 14, 2023
DOI: https://doi.org/10.15441/ceem.22.377
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Chronic juvenile stress exacerbates neurobehavioral dysfunction and neuroinflammation following traumatic brain injury in adult mice
Clin Exp Emerg Med. 2023;10(2):200-212.   Published online February 14, 2023
DOI: https://doi.org/10.15441/ceem.22.377
Close
Objective
Chronic stress in adolescence may affect brain maturation and predispose individuals to psychiatric disorders in adulthood. However, whether chronic juvenile stress influences vulnerability to nonpsychiatric brain injuries, such as traumatic brain injury (TBI), remains unclear. Therefore, we hypothesized that juvenile stress-related neuronal circuit disturbances could aggravate brain damage following TBI in adulthood.
Methods
For chronic stress, we used an unpredictable chronic mild stress (UCMS) procedure for 5 weeks in adolescent mice. This was followed by a controlled cortical impact (CCI) injury to evaluate the influence of chronic juvenile stress on brain damage progression following TBI in adult mice. Mice underwent UCMS alone, UCMS followed by CCI, CCI alone, or sham operation. We characterized neurobehavioral deficits (Barnes maze, open field, and light-dark tests), neuroinflammation (ionized calcium-binding adapter molecule 1 [Iba-1], glial fibrillary acidic protein [GFAP], and neuron-specific nuclear protein [NeuN] immunoreactivity), and apoptosis (B-cell lymp [Bcl-2], Bcl-2-associated X protein [Bax], and procaspase-3 immunoreactivity).
Results
Following CCI, mice exposed to UCMS showed decreased spatial learning and memory in the Barnes maze test compared with unstressed mice. A significant increase in Iba-1, GFAP, and Bax/Bcl-2 immunostaining levels was observed in the mice exposed to UCMS followed by CCI compared with the CCI-only mice. In contrast, a significant decrease in NeuN immunostaining levels was observed in the UCMS with CCI group compared with the CCI alone group.
Conclusion
Chronic stress in a juvenile mouse model aggravates neurobehavioral impairments and potentiates glial reactivity, neuronal injury, and apoptosis following moderate-to-severe TBI that occurs in adulthood. The present study suggests that juvenile chronic stress may influence poor outcomes following TBI in later adulthood.

Citations

Citations to this article as recorded by  Crossref logo
  • Context-dependent attention and memory outcomes resulting from combined prenatal THC and nicotine exposure following chronic stress
    Mariana Delgado, Nicole M. Roeder, Samantha L. Penman, Brittany J. Richardson, Jia Wang, Saptarshi Chakraborty, Panayotis K. Thanos
    Pharmacology Biochemistry and Behavior.2026; 267: 174234.     CrossRef
  • Inhibition of microglia priming by NLRP3 reduces the impact of early life stress and mild TBI
    Fabiola Placeres-Uray, Aditi S. Gorthy, Maria Dominguez Torres, Coleen M. Atkins
    Journal of Neuroinflammation.2025;[Epub]     CrossRef
  • Context is key: glucocorticoid receptor and corticosteroid therapeutics in outcomes after traumatic brain injury
    Morgan A. Taylor, Olga N. Kokiko-Cochran
    Frontiers in Cellular Neuroscience.2024;[Epub]     CrossRef
  • 8,082 View
  • 128 Download
  • 3 Web of Science
  • 3 Crossref

Airway

Efficiency, limitations, and familiarization of a novel negative pressure aerosol box for intubation: a simulation-based randomized crossover study
Youngbin Park, Ki Sub Sung, Ji Hoon Kim, Jinwoo Myung, Ju Young Hong
Clin Exp Emerg Med 2023;10(1):44-51.   Published online January 18, 2023
DOI: https://doi.org/10.15441/ceem.22.342

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Efficiency, limitations, and familiarization of a novel negative pressure aerosol box for intubation: a simulation-based randomized crossover study
Clin Exp Emerg Med. 2023;10(1):44-51.   Published online January 18, 2023
DOI: https://doi.org/10.15441/ceem.22.342
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Efficiency, limitations, and familiarization of a novel negative pressure aerosol box for intubation: a simulation-based randomized crossover study
Clin Exp Emerg Med. 2023;10(1):44-51.   Published online January 18, 2023
DOI: https://doi.org/10.15441/ceem.22.342
Close
Objective
This study aimed to introduce a novel negative pressure aerosol box (Carrycure Isolator) and to test its efficiency and limitations, with the hope of suggesting improvements and further directions.
Methods
A novel aerosol box (Carrycure Isolator) was invented. A single-center, randomized, crossover simulation study of 28 emergency medicine physicians was designed. Three trials of each participant using an intubation manikin were conducted, including intubation without the aerosol box (trial A), intubation with the aerosol box (trial B), and intubation with the aerosol box after familiarization (trial C). The primary endpoint was the time to intubation. The secondary endpoints were first-attempt success, number of attempts, percentage of glottic opening score, and Cormack-Lehane view. Collected data were statistically analyzed for their significance.
Results
The median times to intubation of trials A, B, and C were 30.5 (interquartile range [IQR], 28.0–40.0 seconds), 59.0 (IQR, 50.0–75.5 seconds), and 34.0 seconds (IQR, 30.5–47.0 seconds), respectively. Post hoc analysis showed that the time to intubation in trial B was significantly longer than that in trial A (P<0.05), while that the time to intubation in trial C was significantly shorter than that in trial B (P<0.05). Results concerning secondary endpoints showed similar patterns. Participants reported performing intubation with Carrycure Isolator to be relatively difficult, necessitating significant arm movement and view restrictions while increasing their time to intubation.
Conclusion
Physicians took a longer time to intubate a manikin using the Carrycure Isolator, a novel negative pressure aerosol box. However, the time was improved after a period of familiarization.

Citations

Citations to this article as recorded by  Crossref logo
  • A Portable, Foldable Negative-Pressure Aerosol-Containment System (FNPACS) for Aerosol Control During Aerosol-Generating Procedures
    Bing Rui Huang, Fatimah Ibrahim, Ina Ismiarti Shariffuddin, Puteri Ainaa S. Ibrahim, Li-Yen Chang, Karunan Joseph, Mas Sahidayana Mohktar, Noorjahan Haneem Md Hashim
    Bioengineering.2026; 13(6): 669.     CrossRef
  • A New Method Proposed for Analyzing Airflow Dynamics in Negative Pressure Isolation Chambers Using Particle Image Velocimetry
    Min Jae Oh, Jung Min Moon, Seung Cheol Ko, Min Ji Kim, Ki Sub Sung, Jung Woo Lee, Ju Young Hong, Joon Sang Lee, Yong Hyun Kim
    Bioengineering.2025; 12(3): 302.     CrossRef
  • Enhancing Aerosol Mitigation in Medical Procedures: A CFD-Informed Respiratory Barrier Enclosure
    Ju Young Hong, Seungcheol Ko, Ki Sub Sung, Min Jae Oh, Min Ji Kim, Jung Woo Lee, Yoo Seok Park, Yong Hyun Kim, Joon Sang Lee
    Bioengineering.2024; 11(11): 1104.     CrossRef
  • 6,407 View
  • 161 Download
  • 3 Web of Science
  • 3 Crossref

Education & Simulation

Experience of emergency medical services provider training using online training of trainers during COVID-19: official development assistance project in Tashkent, Uzbekistan
Yongsuk Mun, Joon Min Park, Hoon Kim, Hyunjong Kim, Jungeon Kim, Ajung Kim, Yoo Bin Lee, Woochan Jeon, Hye Weon Kwak
Clin Exp Emerg Med 2022;9(3):238-245.   Published online August 31, 2022
DOI: https://doi.org/10.15441/ceem.21.164

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Experience of emergency medical services provider training using online training of trainers during COVID-19: official development assistance project in Tashkent, Uzbekistan
Clin Exp Emerg Med. 2022;9(3):238-245.   Published online August 31, 2022
DOI: https://doi.org/10.15441/ceem.21.164
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Experience of emergency medical services provider training using online training of trainers during COVID-19: official development assistance project in Tashkent, Uzbekistan
Clin Exp Emerg Med. 2022;9(3):238-245.   Published online August 31, 2022
DOI: https://doi.org/10.15441/ceem.21.164
Close
Objective
Since onsite education is difficult due to the COVID-19 pandemic, official development assistance (ODA) projects have implemented online training of trainers (ToT) for emergency medical experts and staff. This study aims to share and discuss the ToT experience and its results in Uzbekistan.
Methods
We trained emergency medical advanced course instructors through online ToT among emergency medical service experts in Uzbekistan as a part of an ODA project. After the ToT, instructors were selected based on written tests, video monitoring of practice, and simulation performance. They operated the emergency medical course including lectures, practices, and simulations for 5 days. We tested the trainees through written tests before and after the course. They were surveyed regarding the course contents, its relevance, and their satisfaction with the course.
Results
Six instructors were selected after the online ToT program. They educated 68 emergency medical workers through the three training courses. The total score of the pretest was 129.2±34.8, and the posttest score was 170.8±31.2, which was significantly higher (P<0.05). The satisfaction calculated by adding the values of survey items for this curriculum was 28.0 (interquartile range, 26.0–30.0), and there was no statistical difference regarding trainee satisfaction between the three courses (P=0.148).
Conclusion
Instructors trained by online ToT programs could provide an in-person emergency medical advanced course.
  • 6,472 View
  • 181 Download

Emergency Medicine Practice and Administration | Epidemiology

Characteristics of frequent emergency department users in Korea: a 4-year retrospective analysis using Korea Health Panel Study data
Jihoon Yoon, Min Joung Kim, Kyung Hwan Kim, Junseok Park, Dong Wun Shin, Hoon Kim, Woochan Jeon, Hyunjong Kim, Jungeon Kim, Joon Min Park
Clin Exp Emerg Med 2022;9(2):114-119.   Published online June 30, 2022
DOI: https://doi.org/10.15441/ceem.21.151

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Characteristics of frequent emergency department users in Korea: a 4-year retrospective analysis using Korea Health Panel Study data
Clin Exp Emerg Med. 2022;9(2):114-119.   Published online June 30, 2022
DOI: https://doi.org/10.15441/ceem.21.151
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Characteristics of frequent emergency department users in Korea: a 4-year retrospective analysis using Korea Health Panel Study data
Clin Exp Emerg Med. 2022;9(2):114-119.   Published online June 30, 2022
DOI: https://doi.org/10.15441/ceem.21.151
Close
Objective
We aimed to investigate the characteristics of frequent emergency department (ED) users in Korea.
Methods
We analyzed the Korea Health Panel Study data of a sampled population from the 2005 Population Census of Korea data, and adults (age ≥18 years) who visited the ED at least once a year between 2014 and 2017 were included in the study. People who visited three or more times a year were classified as frequent users. We compared demographic, socioeconomic, and health-related factors between nonfrequent and frequent users. We used a multivariable logistic regression analysis to determine factors related to frequent ED visits. We also compared the characteristics of ED use in both nonfrequent and frequent users.
Results
A total of 5,090 panels were included, comprising 6,853 visits. Frequent users were 333 (6.5% of all panels), and their ED visits were 1,364 (19.9% of all ED visits). In the multivariable regression analysis, medical aid coverage (adjusted odds ratio [aOR] of the National Health Service coverage, 0.55; 95% confidence interval [CI], 0.40–0.75), unemployment (aOR of employment, 0.72; 95% CI, 0.56–0.91), prior ward admission in a year (aOR, 2.14; 95% CI, 1.67–2.75), and frequent outpatient department use (aOR, 1.72; 95% CI, 1.35–2.20) were associated with frequent use. Moreover, frequent users visited the ED of public hospitals more often than than nonfrequent users (19.2% vs. 9.8%). Medical problems rather than injury/poisoning were the more common reasons for visiting the ED (84.5% vs. 71.2%).
Conclusion
We found that frequent ED users were likely to be those with socioeconomic disadvantage or with high demand for medical service. Based on this study, further studies on interventions to reduce frequent ED use are required for better ED services.

Citations

Citations to this article as recorded by  Crossref logo
  • O perfil do usuário frequente de um Serviço de Urgência Polivalente: uma realidade arquipelágica
    Alexandra Torres de Medeiros, José Luís Santos Picanço, Nuno Miguel Faria Araújo
    Cogitare Enfermagem.2025;[Epub]     CrossRef
  • El perfil de lo usuario frecuente de un Servicio de Emergencias Polivalente: una realidad archipelágica
    Alexandra Torres de Medeiros, José Luís Santos Picanço, Nuno Miguel Faria Araújo
    Cogitare Enfermagem.2025;[Epub]     CrossRef
  • The profile of frequent user of a Multipurpose Emergency Service: an archipelago reality
    Alexandra Torres de Medeiros, José Luís Santos Picanço, Nuno Miguel Faria Araújo
    Cogitare Enfermagem.2025;[Epub]     CrossRef
  • Characteristics of consecutive versus non-consecutive frequent emergency medical services transport to a single emergency department
    Sun Hyu Kim, Hyeji Lee, Fadwa Alhalaiqa
    PLOS ONE.2024; 19(5): e0301337.     CrossRef
  • Status and trends of medical expenditures for poisoning patients
    Eung Nam Kim, Soyoung Jeon, Hye Sun Lee, Sung Phil Chung
    Journal of The Korean Society of Clinical Toxicology.2023; 21(1): 24.     CrossRef
  • Fatores associados ao uso não urgente dos serviços de emergência da Unidade de Pronto Atendimento da FHMMF em Pirapora – MG
    Thiago Vinicius dos Santos Ferreira, Letícia Rocha Oliveira Matos, Luana Rocha Oliveira Matos, Luiza Santos Ribeiro Da Silva, Samia Machado Melo
    Cuadernos de Educación y Desarrollo.2023; 15(8): 7869.     CrossRef
  • 7,731 View
  • 199 Download
  • 2 Web of Science
  • 6 Crossref

Experimental study | Trauma

Secondary hypoxic ischemia alters neurobehavioral outcomes, neuroinflammation, and oxidative stress in mice exposed to controlled cortical impact
Se-Kwang Oh, Hyun-Jeong Park, Gyeong-Gyu Yu, Seong-Hae Jeong, Suk-Woo Lee, Hoon Kim
Clin Exp Emerg Med 2021;8(3):216-228.   Published online September 30, 2021
DOI: https://doi.org/10.15441/ceem.20.124

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Secondary hypoxic ischemia alters neurobehavioral outcomes, neuroinflammation, and oxidative stress in mice exposed to controlled cortical impact
Clin Exp Emerg Med. 2021;8(3):216-228.   Published online September 30, 2021
DOI: https://doi.org/10.15441/ceem.20.124
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Secondary hypoxic ischemia alters neurobehavioral outcomes, neuroinflammation, and oxidative stress in mice exposed to controlled cortical impact
Clin Exp Emerg Med. 2021;8(3):216-228.   Published online September 30, 2021
DOI: https://doi.org/10.15441/ceem.20.124
Close
Objective
Hypoxic ischemia (HI) is a secondary insult that can cause fatal neurologic outcomes after traumatic brain injury (TBI), ranging from mild cognitive deficits to persistent vegetative states. We here aimed to unravel the underlying pathological mechanisms of HI injury in a TBI mouse model.
Methods
Neurobehavior, neuroinflammation, and oxidative stress were assessed in a mouse model of controlled cortical impact (CCI) injury followed by HI. Mice underwent CCI alone, CCI followed by HI, HI alone, or sham operation. HI was induced by one-vessel carotid ligation with 1 hour of 8% oxygen in nitrogen. Learning and memory were assessed using the novel object recognition test, contextual and cued fear conditioning, and Barnes maze test. Brain cytokine production and oxidative stress-related components were measured.
Results
Compared to TBI-only animals, TBI followed by HI mice exhibited significantly poorer survival and health scores, spatial learning and memory in the Barnes maze test, discrimination memory in the novel object recognition test, and fear memory following contextual and cued fear conditioning. Malondialdehyde levels were significantly lower, whereas glutathione peroxidase activity was significantly higher in TBI followed by HI mice compared to TBI-only and sham counterparts, respectively. Interleukin-6 levels were significantly higher in TBI followed by HI mice compared to both TBI-only and sham animals.
Conclusion
Post-traumatic HI aggravated deficits in spatial, fear, and discrimination memory in an experimental TBI mouse model. Our results suggest that increased neuroinflammation and oxidative stress contribute to HI-induced neurobehavioral impairments after TBI.

Citations

Citations to this article as recorded by  Crossref logo
  • The immunological landscape of traumatic brain injury: insights from pathophysiology to experimental models
    Matthew Abikenari, Joseph H. Ha, Justin Liu, Alexander Ren, Kwang Bog Cho, Jaejoon Lim, Lily H. Kim, Ravi Medikonda, John Choi, Michael Lim
    Frontiers in Neurology.2025;[Epub]     CrossRef
  • The long-term influences of age at injury on neuroinflammation and neuronal apoptosis following traumatic brain injury in pediatric and adult mice
    Jin-Soo Park, Hyun-Jeong Park, Young-Min Kim, Hyun-Seok Chai, Gwan Jin Park, Sang-Chul Kim, Gyeong-Gyu Yu, Suk-Woo Lee, Hoon Kim
    Clinical and Experimental Emergency Medicine.2025; 12(3): 267.     CrossRef
  • Chronic juvenile stress exacerbates neurobehavioral dysfunction and neuroinflammation following traumatic brain injury in adult mice
    Sung-Jin Park, Hyun-Jeong Park, Backyoun Kim, Young-Min Kim, Suk-Woo Lee, Hoon Kim
    Clinical and Experimental Emergency Medicine.2023; 10(2): 200.     CrossRef
  • 9,243 View
  • 80 Download
  • 4 Web of Science
  • 3 Crossref

Toxicology | Epidemiology

Incidence patterns of nervous system diseases after carbon monoxide poisoning: a retrospective longitudinal study in South Korea from 2012 to 2018
Bangshill Rhee, Hyuk-Hoon Kim, Sangchun Choi, Young Gi Min
Clin Exp Emerg Med 2021;8(2):111-119.   Published online June 30, 2021
DOI: https://doi.org/10.15441/ceem.20.099

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Incidence patterns of nervous system diseases after carbon monoxide poisoning: a retrospective longitudinal study in South Korea from 2012 to 2018
Clin Exp Emerg Med. 2021;8(2):111-119.   Published online June 30, 2021
DOI: https://doi.org/10.15441/ceem.20.099
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Incidence patterns of nervous system diseases after carbon monoxide poisoning: a retrospective longitudinal study in South Korea from 2012 to 2018
Clin Exp Emerg Med. 2021;8(2):111-119.   Published online June 30, 2021
DOI: https://doi.org/10.15441/ceem.20.099
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Objective
To analyze the incidence patterns of nervous system diseases in survivors of carbon monoxide (CO) poisoning using nationwide claims data from South Korea.
Methods
A national cohort was abstracted from a database that includes patients diagnosed with CO poisoning between January 2012 and December 2018. For all nervous system diseases, we investigated the frequency, pattern of incidence, effect of intensive care unit admission, and the standardized incidence ratios (SIRs) to estimate the risk of nervous system disease after CO poisoning.
Results
Of 26,778 patients, 18,720 (69.9%) were diagnosed with nervous system diseases after CO poisoning. The most common disease was disorders of sleep initiation and maintenance (n=701, 3.74%), followed by tension-type headache (n=477, 2.55%) and anoxic brain injury (n=406, 2.17%). Over half of the nervous system diseases occurred within the first year after CO poisoning. The cumulative hazard ratio for nervous system diseases in patients admitted to the intensive care unit was 2.25 (95% confidence interval [CI], 2.07–2.44). Among the frequent nervous system diseases after CO poisoning, patients had a higher risk of disorders of initiating and maintaining sleep (SIR, 1.61; 95% CI, 1.52–1.71), tension-type headache (SIR, 2.41; 95% CI, 2.23–2.61), anoxic brain injury (SIR, 58.76; 95% CI, 53.95–63.88), and post-zoster neuralgia (SIR, 1.94; 95% CI, 1.70–2.20).
Conclusion
Patients who experience CO poisoning are at higher risk for several nervous system diseases. Therefore, monitoring for specific nervous system diseases is important after CO poisoning within the first year.

Citations

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  • A double-blind randomized trial of hyperbaric oxygen for persistent symptoms after brain injury
    Lindell K. Weaver, Rosemary Ziemnik, Kayla Deru, Antonietta A. Russo
    Scientific Reports.2025;[Epub]     CrossRef
  • Machine Learning–Based Prediction of Delayed Neurologic Sequelae in Carbon Monoxide Poisoning Using Automatically Extracted MR Imaging Features
    Grace Yoojin Lee, Chang Hwan Sohn, Dongwon Kim, Sang-Beom Jeon, Jihye Yun, Sungwon Ham, Yoojin Nam, Jieun Yum, Won Young Kim, Namkug Kim
    American Journal of Neuroradiology.2025; 46(12): 2645.     CrossRef
  • Characteristics and toxicity of burning smoke released from non-metallic materials of ships in a closed environment
    Jing Yang, Zhi Li, Xun Liu, Xiaomeng Ren, Jun Wu, Xinhong Xu, Xiaochen Bao, Lu Jiang, Jingjing Fang
    Journal of Hazardous Materials.2024; 480: 136109.     CrossRef
  • Long-term mortality of adult patients with carbon monoxide poisoning presenting to the emergency department in Korea: a population-based cohort study
    Sang Hwan Lee, Soo Rack Ryu, Kyung Hun Yoo, Juncheol Lee, Yongil Cho, Tae Ho Lim, Hyunggoo Kang, Jaehoon Oh, Byuk Sung Ko
    Acute and Critical Care.2024; 39(4): 526.     CrossRef
  • Prevalence of Carbon Monoxide Poisoning and Hyperbaric Oxygen Therapy in Korea: Analysis of National Claims Data in 2010–2019
    Eunah Han, Gina Yu, Hye Sun Lee, Goeun Park, Sung Phil Chung
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • Predicting acute brain lesions on magnetic resonance imaging in acute carbon monoxide poisoning: a multicenter prospective observational study
    Kyung Hun Yoo, Hyunggoo Kang, Jaehoon Oh, Tae Ho Lim, Yongil Cho, Juncheol Lee, Sang Hwan Lee, Seungkyo Jung, Won Young Kim, Chang Hwan Sohn, Byuk Sung Ko
    Scientific Reports.2023;[Epub]     CrossRef
  • Level of knowledge about carbon monoxide poisoning and its prevention among students of the Medical School of the Universidad Abierta Interamericana of the city of Rosario (Argentina) in the year 2023
    Sofía Bonardi, Rodolfo Verrone
    Health Leadership and Quality of Life.2023; 2: 68.     CrossRef
  • Prevalence of Acute Myocardial and Brain Toxicity in Emergency Department Patients Exposed to Carbon Monoxide
    Carolina Zúñiga, Luisa Fabiola Pérez Moreno, Shirley Liperguer, Verónica Torres Cerino
    Open Journal of Emergency Medicine.2023; 11(04): 198.     CrossRef
  • Tips for avoiding common mistakes in out-of-hospital diagnosis of carbon monoxide poisoning
    G. Fucili, M. Brauzzi
    Journal of Anesthesia, Analgesia and Critical Care.2022;[Epub]     CrossRef
  • Carbon Monoxide Poisoning was Associated With Lifetime Suicidal Ideation: Evidence From A Population-Based Cross-Sectional Study in Hebei Province, China
    Long Sun, Keqing Li, Yunshu Zhang, Lili Zhang
    International Journal of Public Health.2022;[Epub]     CrossRef
  • Prognostic value of the myeloperoxidase index for early prediction of neurologic outcome in acute carbon monoxide poisoning
    Joong Seok Moon, Sung Hwa Kim, Yong Sung Cha
    Clinical and Experimental Emergency Medicine.2022; 9(3): 230.     CrossRef
  • Serum phosphate is not an early predictor of neurocognitive outcomes in acute carbon monoxide poisoning patients
    Yuseon Lee, Sung Hwa Kim, Yong Sung Cha
    Clinical and Experimental Emergency Medicine.2022; 10(1): 74.     CrossRef
  • 8,538 View
  • 126 Download
  • 11 Web of Science
  • 12 Crossref
Epidemiology and regional differences of acute poisonings of eight cities in Gyeonggi-do province in Korea using data from the National Emergency Department Information System of Korea
Seungho Ham, Young Gi Min, Minjung Kathy Chae, Hyuk-Hoon Kim
Clin Exp Emerg Med 2020;7(1):43-51.   Published online March 31, 2020
DOI: https://doi.org/10.15441/ceem.19.014

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Epidemiology and regional differences of acute poisonings of eight cities in Gyeonggi-do province in Korea using data from the National Emergency Department Information System of Korea
Clin Exp Emerg Med. 2020;7(1):43-51.   Published online March 31, 2020
DOI: https://doi.org/10.15441/ceem.19.014
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Epidemiology and regional differences of acute poisonings of eight cities in Gyeonggi-do province in Korea using data from the National Emergency Department Information System of Korea
Clin Exp Emerg Med. 2020;7(1):43-51.   Published online March 31, 2020
DOI: https://doi.org/10.15441/ceem.19.014
Close
Objective
We aimed to analyze the differences in epidemiological aspects and clinical courses of acute poisonings in each region of the Gyeonggi-do province in Korea.

Methods
This retrospective study analyzed data from the National Emergency Department Information System of Korea. We retrospectively reviewed cases of acute poisonings between April 2006 and March 2015 recorded at 13 emergency departments in eight different cities of Gyeonggi-do province in Korea. The differences in the incidence, age distribution, causative agent, and clinical course of poisonings among regions were the main outcomes measured.

Results
The proportion of poisonings in the ≤9 age group was high in Yongin (17.44%) and that in ≥65 age group was high in Gwangmyeong (21.76%). The proportion of cases involving carbon monoxide was high in Ansan (8.82%) in patients hospitalized and the proportion of cases involving pesticides was high in Pyeongtaek (52.78%) in patients admitted to the intensive care unit. The admission rate of poisoned patients was high in Osan (36.02%).

Conclusion
In this study, differences in the characteristics of poisoned patients between 8 cities were noted. Therefore, hospitals need to arrange treatment resources for poisoned patients according to the characteristics of the specific region. The results of this study may serve as evidence for new strategies to prepare for the acute poisonings in hospitals.

Citations

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  • A four-way patient search method for the retrospective identification of poisoning patients
    Veronika Uslin, Ville Hällberg, Timo Lukkarinen, Marjo Niskanen, Teemu Koivistoinen, Ari Palomäki
    Scientific Reports.2024;[Epub]     CrossRef
  • Clinical support system for triage based on federated learning for the Korea triage and acuity scale
    Hansol Chang, Jae Yong Yu, Geun Hyeong Lee, Sejin Heo, Se Uk Lee, Sung Yeon Hwang, Hee Yoon, Won Chul Cha, Tae Gun Shin, Min Seob Sim, Ik Joon Jo, Taerim Kim
    Heliyon.2023; 9(8): e19210.     CrossRef
  • Characterization of Acute Poisoning in Hospitalized Children in Southwest China
    Zhu Li, Li Xiao, Lin Yang, Shaojun Li, Liping Tan
    Frontiers in Pediatrics.2021;[Epub]     CrossRef
  • Development of a Mobile Personal Health Record Application Designed for Emergency Care in Korea; Integrated Information from Multicenter Electronic Medical Records
    Yuri Choi, June-sung Kim, In Ho Kwon, Taerim Kim, Su Min Kim, Wonchul Cha, Jinwoo Jeong, Jae-Ho Lee
    Applied Sciences.2020; 10(19): 6711.     CrossRef
  • Frequency and Management of Acute Poisoning Among Children Attending an Emergency Department in Saudi Arabia
    Mansour Tobaiqy, Bandar A. Asiri, Ahmed H. Sholan, Yahya A. Alzahrani, Ayed A. Alkatheeri, Ahmed M. Mahha, Shamsia S. Alzahrani, Katie MacLure
    Pharmacy.2020; 8(4): 189.     CrossRef
  • 8,098 View
  • 122 Download
  • 7 Web of Science
  • 5 Crossref

Procedures

Use of smart glasses for ultrasound-guided peripheral venous access: a randomized controlled pilot study
Hyunmook Lim, Min Joung Kim, Joon Min Park, Kyung Hwan Kim, Junseok Park, Dong Wun Shin, Hoon Kim, Woochan Jeon, Hyunjong Kim, Jungeon Kim
Clin Exp Emerg Med 2019;6(4):356-361.   Published online December 31, 2019
DOI: https://doi.org/10.15441/ceem.19.029

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Use of smart glasses for ultrasound-guided peripheral venous access: a randomized controlled pilot study
Clin Exp Emerg Med. 2019;6(4):356-361.   Published online December 31, 2019
DOI: https://doi.org/10.15441/ceem.19.029
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Use of smart glasses for ultrasound-guided peripheral venous access: a randomized controlled pilot study
Clin Exp Emerg Med. 2019;6(4):356-361.   Published online December 31, 2019
DOI: https://doi.org/10.15441/ceem.19.029
Close
Objective
Smart glasses can provide sonographers with real-time ultrasound images. In the present study, we aimed to evaluate the utility of smart-glasses for ultrasound-guided peripheral venous access.
Methods
In this randomized, crossover-design, simulation study, 12 participants were recruited from the emergency department residents at a university hospital. Each participant attempted ultrasound-guided peripheral venous access on a pediatric phantom at intervals of 5 days with (glasses group) or without (non-glasses group) the use of smart glasses. In the glasses group, participants confirmed the ultrasound image through the lens of the smart glasses. In the non-glasses group, participants confirmed the ultrasound image through the display viewer located next to the phantom. Procedure time was regarded as the primary outcome, while secondary outcomes included the number of head movements for the participant, number of skin punctures, number of needle redirections, and subjective difficulty.
Results
No significant differences in procedural time were observed between the groups (non-glasses group: median time, 15.5 seconds; interquartile range [IQR], 10.3 to 27.3 seconds; glasses group: median time, 19.0 seconds; IQR, 14.3 to 39.3 seconds; P=0.58). The number of head movements was lower in the glasses group than in the non-glasses group (glasses group: median, 0; IQR, 0 to 0; non-glasses group: median, 4; IQR, 3 to 5; P<0.01). No significant differences in the number of skin punctures or needle restrictions were observed between the groups.
Conclusion
Our results indicate that smart-glasses may aid in ensuring ultrasound-guided peripheral venous access by reducing head movements.

Citations

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  • Canalización vascular guiada por la visión directa de la imagen ecográfica a través de gafas de realidad aumentada. ¿Es posible? ¿Será útil?
    Carmen Espinosa Pereiro, Rita García Fernández, Miguel A. Rodríguez Vargas, Luis Crego Rodríguez, Antonio Rodríguez Núñez
    Anales de Pediatría.2026; 104(2): 504104.     CrossRef
  • Direct view through smart glasses guided vascular cannulation. Is it feasible? Will it be useful?
    Carmen Espinosa Pereiro, Rita García Fernández, Miguel A. Rodríguez Vargas, Luis Crego Rodríguez, Antonio Rodríguez Núñez
    Anales de Pediatría (English Edition).2026; 104(2): 504104.     CrossRef
  • Use of smart glasses for ultrasound-guided radial arterial catheterisation in obese patients: study protocol for a single-centre randomised clinical trial in China
    Yuwen Wang, Qiang Yu, Tingting Xue, Enqiang Guo, Yun Wu
    BMJ Open.2026; 16(2): e111115.     CrossRef
  • Smart glasses integrated with a wireless ultrasound system for radial artery catheterization in elderly patients: a randomized controlled trial
    Wudong Zhuang, Ruizhao Lyu, Xiaoyuan Li, Yang Bai, Rui Liu, Jianhua Wang
    Frontiers in Medicine.2026;[Epub]     CrossRef
  • Looking through the crystal ball feasibility of tele-echocardiography using smart glasses in neonates: a pilot study
    A. Michaelis, M. Weidenbach, I. Altmann, F. Markel, F. Löffelbein, I. Dähnert, R.A. Gebauer, C. Paech
    Cardiology in the Young.2025; 35(1): 87.     CrossRef
  • A Mixed Reality–Based Telesupervised Ultrasound Education Platform on 5G Network Compared to Direct Supervision: Prospective Randomized Pilot Trial
    Minha Kim, Meong Hi Son, Suhyeon Moon, Won Chul Cha, Ik Joon Jo, Hee Yoon
    JMIR Serious Games.2025; 13: e63448.     CrossRef
  • Use of smart glasses imaging for interscalene brachial plexus block: a randomised clinical trial
    Ping Liu, Jiaqi Qiu, Furui Wang, Rui Li, Ye Zhang, Yun Wu, Lingling Jiang
    British Journal of Anaesthesia.2025; 135(4): 1067.     CrossRef
  • Effectiveness of head-mounted ultrasound display for radial arterial catheterisation in paediatric patients by anaesthesiology trainees
    Jin-Tae Kim, Jung-Bin Park, Pyoyoon Kang, Sang-Hwan Ji, Eun-Hee Kim, Ji-Hyun Lee, Hee-Soo Kim, Young-Eun Jang.
    European Journal of Anaesthesiology.2024; 41(7): 522.     CrossRef
  • Augmented reality for point-of-care ultrasound-guided vascular access in pediatric patients using Microsoft HoloLens 2: a preliminary evaluation
    Gesiren Zhang, Trong N. Nguyen, Hadi Fooladi-Talari, Tyler Salvador, Kia Thomas, Daragh Crowley, R. Scott Dingeman, Raj Shekhar
    Journal of Medical Imaging.2024;[Epub]     CrossRef
  • The effect of smart glasses combined with ultrasound on radial arterial catheterization: a randomized controlled trial
    Yan Wang, Mingjing Chen, Ting Zou, Yan Weng, Wenjie Mao, Qing Zhong, Haibo Song
    BMC Anesthesiology.2024;[Epub]     CrossRef
  • Laser guidance for ultrasound-guided radial artery catheterization using smart glasses: a randomized trial
    Yoon Jung Kim, Chul-Woo Jung, Seungeun Choi, Youngwon Kim, Jeoung-Hwa Seo
    Canadian Journal of Anesthesia/Journal canadien d'anesthésie.2023; 70(10): 1635.     CrossRef
  • Smart Glasses to Facilitate Ultrasound Guided Peripheral Intravenous Access in the Simulation Setting for Thai Emergency Medical Service Providers
    Kamonwon Ienghong, Lap Woon Cheung, Pornpawit Wongwan, Korakot Apiratwarakul
    Journal of Multidisciplinary Healthcare.2023; Volume 16: 2201.     CrossRef
  • Assessing the Effect of Augmented Reality on Procedural Outcomes During Ultrasound-Guided Vascular Access
    Michele S. Saruwatari, Trong N. Nguyen, Hadi Fooladi Talari, Andrew J. Matisoff, Karun V. Sharma, Kelsey G. Donoho, Sonali Basu, Pallavi Dwivedi, James E. Bost, Raj Shekhar
    Ultrasound in Medicine & Biology.2023; 49(11): 2346.     CrossRef
  • Smart Glasses for Radial Arterial Catheterization in Pediatric Patients: A Randomized Clinical Trial
    Young-Eun Jang, Sung-Ae Cho, Sang-Hwan Ji, Eun-Hee Kim, Ji-Hyun Lee, Hee-Soo Kim, Jin-Tae Kim
    Anesthesiology.2021; 135(4): 612.     CrossRef
  • Smart glasses display device for fluoroscopically guided minimally invasive spinal instrumentation surgery: a preliminary study
    Keitaro Matsukawa, Yoshiyuki Yato
    Journal of Neurosurgery: Spine.2021; 34(1): 150.     CrossRef
  • 9,980 View
  • 153 Download
  • 15 Web of Science
  • 15 Crossref

Environmental

Predictors of poor prognosis in patients with heat stroke
Jae-Kwon Chun, Sangchun Choi, Hyuk-Hoon Kim, Hee Won Yang, Chang Seong Kim
Clin Exp Emerg Med 2019;6(4):345-350.   Published online December 31, 2019
DOI: https://doi.org/10.15441/ceem.18.081

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Predictors of poor prognosis in patients with heat stroke
Clin Exp Emerg Med. 2019;6(4):345-350.   Published online December 31, 2019
DOI: https://doi.org/10.15441/ceem.18.081
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Predictors of poor prognosis in patients with heat stroke
Clin Exp Emerg Med. 2019;6(4):345-350.   Published online December 31, 2019
DOI: https://doi.org/10.15441/ceem.18.081
Close
Objective
The predictors of poor prognosis in heat stroke (HS) remain unknown. This study investigated the predictive factors of poor prognosis in patients with HS.
Methods
Data were obtained and analyzed from the health records of patients diagnosed with heat illness at Ajou university hospital between January 2008 and December 2017. Univariate and multivariate analyses were performed to identify the independent predictors of poor prognosis.
Results
Thirty-six patients (median age, 54.5 years; 33 men) were included in the study. Poor prognosis was identified in 27.8% of the study population (10 patients). The levels of S100B protein, troponin I, creatinine, alanine aminotransferase, and serum lactate were statistically significant in the univariate analysis. Multiple regression analysis revealed that poor prognosis was significantly associated with an increased S100B protein level (odds ratio, 177.37; 95% confidence interval, 2.59 to 12,143.80; P=0.016). The S100B protein cut-off level for predicting poor prognosis was 0.610 μg/L (area under the curve, 0.906; 95% confidence interval, 0.00 to 1.00), with 86% sensitivity and 86% specificity.
Conclusion
An increased S100B protein level on emergency department admission is an independent prognostic factor of poor prognosis in patients with HS. Elevation of the S100B protein level represents a potential target for specific and prompt therapies in these patients.

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  • Energy metabolic dysregulation in heat stroke: from mitochondrial dysfunction to multi-organ failure mechanisms and targeted intervention
    Qiqi Li, Jinquan Wang, Xiaojie Qin, Biaochao Zhong, Qiantong Wei, Chunhui Zeng, Ke Yang
    Frontiers in Pharmacology.2026;[Epub]     CrossRef
  • Cracking the code of heatstroke: new insights into diagnosis and pathological mechanisms
    Hongli Xiong, Cunhao Bian, Yue Zhao, Yu sen Wang, Bi Wei, Hao Xiao, Li Zhang, Shisheng Zhu, Jianbo Li
    International Journal of Legal Medicine.2026;[Epub]     CrossRef
  • Grey-to-white matter ratio on computed tomography for predicting neurological outcome in patients with heat stroke: a retrospective cohort study
    Hua Wei, Hongling Zhu, Menglong Liu, Xiaodan Zhu, Anyong Yu, Can Luo, Qingbo Zeng, Fating Zhou, Haizhen Duan
    Frontiers in Neurology.2025;[Epub]     CrossRef
  • Age-leukocyte-international normalized ratio score (ALIS): A bedside triparametric tool for neurological prognostication in heat stroke emergencies
    Fating Zhou, Xiaodan Zhu, Haizhen Duan, Yunfei Xiang, Siyu Yang, Wanshu Que, Rui Huang, Shanmu Ai, Yu Ma
    The American Journal of Emergency Medicine.2025; 96: 217.     CrossRef
  • Prediction of in-hospital mortality in patients with exertional heatstroke: a 13-year retrospective study
    Xinghui Wu, Jing Qian, Songbin He, Xuezhi Shi, Ronglin Chen, Huaisheng Chen, LuLu Wang, Fanfan Wang, Jiale Yang, Na Peng, Huasheng Tong
    International Journal of Environmental Health Research.2024; 34(6): 2451.     CrossRef
  • How can heatstroke damage the brain? A mini review
    Kazuhiro Yoneda, Sanae Hosomi, Hiroshi Ito, Yuki Togami, Sayaka Oda, Hisatake Matsumoto, Junya Shimazaki, Hiroshi Ogura, Jun Oda
    Frontiers in Neuroscience.2024;[Epub]     CrossRef
  • Biomarkers of heatstroke‐induced organ injury and repair
    Zachary J. Schlader, Michael S. Davis, Abderrezak Bouchama
    Experimental Physiology.2022; 107(10): 1159.     CrossRef
  • Targeted temperature management in patients with severe heatstroke
    Yoon Seok Jung, Hyuk-Hoon Kim, Hee Won Yang, Sangchun Choi
    Medicine.2020; 99(45): e23159.     CrossRef
  • 9,128 View
  • 140 Download
  • 10 Web of Science
  • 8 Crossref

Experimental study | Trauma

Exploratory, cognitive, and depressive-like behaviors in adult and pediatric mice exposed to controlled cortical impact
Suk-Woo Lee, Mun-Sun Jang, Seong-Hae Jeong, Hoon Kim
Clin Exp Emerg Med 2019;6(2):125-137.   Published online June 28, 2019
DOI: https://doi.org/10.15441/ceem.18.019

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Exploratory, cognitive, and depressive-like behaviors in adult and pediatric mice exposed to controlled cortical impact
Clin Exp Emerg Med. 2019;6(2):125-137.   Published online June 28, 2019
DOI: https://doi.org/10.15441/ceem.18.019
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Exploratory, cognitive, and depressive-like behaviors in adult and pediatric mice exposed to controlled cortical impact
Clin Exp Emerg Med. 2019;6(2):125-137.   Published online June 28, 2019
DOI: https://doi.org/10.15441/ceem.18.019
Close
Objective
Sequelae of behavioral impairments associated with human traumatic brain injury (TBI) include neurobehavioral problems. We compared exploratory, cognitive, and depressive-like behaviors in pediatric and adult male mice exposed to controlled cortical impact (CCI).
Methods
Pediatric (21 to 25 days old) and adult (8 to 12 weeks old) male C57Bl/6 mice underwent CCI at a 2-mm depth of deflection. Hematoxylin and eosin staining was performed 3 to 7 days after recovery from CCI, and injury volume was analyzed using ImageJ. Neurobehavioral characterization after CCI was performed using the Barnes maze test (BMT), passive avoidance test, open-field test, light/dark test, tail suspension test, and rotarod test. Acutely and subacutely (3 and 7 days after CCI, respectively), CCI mice showed graded injury compared to sham mice for all analyzed deflection depths.
Results
Time-dependent differences in injury volume were noted between 3 and 7 days following 2-mm TBI in adult mice. In the BMT, 2-mm TBI adults showed spatial memory deficits compared to sham adults (P<0.05). However, no difference in spatial learning and memory was found between sham and 2-mm CCI groups among pediatric mice. The open-field test, light/dark test, and tail suspension test did not reveal differences in anxiety-like behaviors in both age groups.
Conclusion
Our findings revealed a graded injury response in both age groups. The BMT was an efficient cognitive test for assessing spatial/non-spatial learning following CCI in adult mice; however, spatial learning impairments in pediatric mice could not be assessed.

Citations

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  • Mild pediatric traumatic brain injury has sex-specific effects on neuroimmune cells and social behavior in rats
    Michaela R. Breach, Brooke Schatz, Habib E. Akouri, Zoe M. Tapp, Alejandra Zaleta Lastra, Alexander E. Weinstein, Minna Mohamed, Ashley E. Walters, Reem Mohamed, Olimjon Toirov, Marissa A. Smail, Cole Vonder Haar, Olga N. Kokiko-Cochran, Kathryn M. Lenz
    Scientific Reports.2026;[Epub]     CrossRef
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    Bar Richmond-Hacham, Chaim G. Pick, Lior Bikovski
    Experimental Neurology.2026; 405: 115929.     CrossRef
  • The long-term influences of age at injury on neuroinflammation and neuronal apoptosis following traumatic brain injury in pediatric and adult mice
    Jin-Soo Park, Hyun-Jeong Park, Young-Min Kim, Hyun-Seok Chai, Gwan Jin Park, Sang-Chul Kim, Gyeong-Gyu Yu, Suk-Woo Lee, Hoon Kim
    Clinical and Experimental Emergency Medicine.2025; 12(3): 267.     CrossRef
  • Multiplexed Quantitative Proteomics Reveals Proteomic Alterations in Two Rodent Traumatic Brain Injury Models
    Junho Park, Seung Hak Lee, Dongyoon Shin, Yeongshin Kim, Young Sik Kim, Min Yong Seong, Jin Joo Lee, Han Gil Seo, Won-Sang Cho, Young Sun Ro, Youngsoo Kim, Byung-Mo Oh
    Journal of Proteome Research.2024; 23(1): 249.     CrossRef
  • KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury
    Jesse D. Lai, Joshua E. Berlind, Gabriella Fricklas, Cecilia Lie, Jean-Paul Urenda, Kelsey Lam, Naomi Sta Maria, Russell Jacobs, Violeta Yu, Zhen Zhao, Justin K. Ichida
    Cell Stem Cell.2024; 31(4): 519.     CrossRef
  • Neurobiochemical, Peptidomic, and Bioinformatic Approaches to Characterize Tauopathy Peptidome Biomarker Candidates in Experimental Mouse Model of Traumatic Brain Injury
    Hamad Yadikar, Connor Johnson, Niko Pafundi, Lynn Nguyen, Milin Kurup, Isabel Torres, Albandery Al-Enezy, Zhihui Yang, Richard Yost, Firas H. Kobeissy, Kevin K. W. Wang
    Molecular Neurobiology.2023; 60(4): 2295.     CrossRef
  • Chronic juvenile stress exacerbates neurobehavioral dysfunction and neuroinflammation following traumatic brain injury in adult mice
    Sung-Jin Park, Hyun-Jeong Park, Backyoun Kim, Young-Min Kim, Suk-Woo Lee, Hoon Kim
    Clinical and Experimental Emergency Medicine.2023; 10(2): 200.     CrossRef
  • The pros and cons of motor, memory, and emotion-related behavioral tests in the mouse traumatic brain injury model
    Ruoyu Zhang, Junming Wang, Leo Huang, Tom J. Wang, Yinrou Huang, Zefu Li, Jinxin He, Chen Sun, Jing Wang, Xuemei Chen, Jian Wang
    Neurological Research.2022; 44(1): 65.     CrossRef
  • Comparison of young male mice of two different strains (C57BL/6J and the hybrid B6129SF1/J) in selected behavior tests: a small scale study
    Kristine Eraker Aasland Hansen, Alexandra M. Hudecová, Fred Haugen, Eystein Skjerve, Erik Ropstad, Karin E. Zimmer
    Laboratory Animal Research.2022;[Epub]     CrossRef
  • The inhibition of mammalian target of rapamycin (mTOR) in improving inflammatory response after traumatic brain injury
    Michela Campolo, Giovanna Casili, Marika Lanza, Alessia Filippone, Marika Cordaro, Alessio Ardizzone, Sarah Adriana Scuderi, Salvatore Cuzzocrea, Emanuela Esposito, Irene Paterniti
    Journal of Cellular and Molecular Medicine.2021; 25(16): 7855.     CrossRef
  • Traumatic Brain Injury: An Age-Dependent View of Post-Traumatic Neuroinflammation and Its Treatment
    Clément Delage, Toufik Taib, Célia Mamma, Dominique Lerouet, Valérie C. Besson
    Pharmaceutics.2021; 13(10): 1624.     CrossRef
  • Secondary hypoxic ischemia alters neurobehavioral outcomes, neuroinflammation, and oxidative stress in mice exposed to controlled cortical impact
    Se-Kwang Oh, Hyun-Jeong Park, Gyeong-Gyu Yu, Seong-Hae Jeong, Suk-Woo Lee, Hoon Kim
    Clinical and Experimental Emergency Medicine.2021; 8(3): 216.     CrossRef
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    Laura B. Tucker, Joseph T. McCabe
    Frontiers in Behavioral Neuroscience.2021;[Epub]     CrossRef
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    Agata Ciechanowska, Katarzyna Popiolek-Barczyk, Katarzyna Pawlik, Katarzyna Ciapała, Marco Oggioni, Domenico Mercurio, Maria-Grazia De Simoni, Joanna Mika
    Immunobiology.2020; 225(3): 151911.     CrossRef
  • Modeling Controlled Cortical Impact Injury in 3D Brain‐Like Tissue Cultures
    Volha Liaudanskaya, Joon Yong Chung, Craig Mizzoni, Nicolas Rouleau, Alexander N. Berk, Limin Wu, Julia A. Turner, Irene Georgakoudi, Michael J. Whalen, Thomas J. F. Nieland, David L. Kaplan
    Advanced Healthcare Materials.2020;[Epub]     CrossRef
  • CREB Coactivator CRTC2 Plays a Crucial Role in Endothelial Function
    Hideaki Kanki, Tsutomu Sasaki, Shigenobu Matsumura, Tomohiro Kawano, Kenichi Todo, Shuhei Okazaki, Kumiko Nishiyama, Hiroshi Takemori, Hideki Mochizuki
    The Journal of Neuroscience.2020; 40(49): 9533.     CrossRef
  • 14,283 View
  • 203 Download
  • 17 Web of Science
  • 16 Crossref

Resuscitation

Pilot study on a rewarming rate of 0.15°C/hr versus 0.25°C/hr and outcomes in post cardiac arrest patients
Eunhye Cho, Sung Eun Lee, Eunjung Park, Hyuk-Hoon Kim, Ji Sook Lee, Sangchun Choi, Young Gi Min, Minjung Kathy Chae
Clin Exp Emerg Med 2019;6(1):25-30.   Published online February 20, 2019
DOI: https://doi.org/10.15441/ceem.17.275

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Pilot study on a rewarming rate of 0.15°C/hr versus 0.25°C/hr and outcomes in post cardiac arrest patients
Clin Exp Emerg Med. 2019;6(1):25-30.   Published online February 20, 2019
DOI: https://doi.org/10.15441/ceem.17.275
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Pilot study on a rewarming rate of 0.15°C/hr versus 0.25°C/hr and outcomes in post cardiac arrest patients
Clin Exp Emerg Med. 2019;6(1):25-30.   Published online February 20, 2019
DOI: https://doi.org/10.15441/ceem.17.275
Close
Objective
Cerebral hemodynamic and metabolic changes may occur during the rewarming phase of targeted temperature management in post cardiac arrest patients. Yet, studies on different rewarming rates and patient outcomes are limited. This study aimed to investigate post cardiac arrest patients who were rewarmed with different rewarming rates after 24 hours of hypothermia and the association of these rates to the neurologic outcomes.
Methods
This study retrospectively investigated post cardiac arrest patients treated with targeted temperature management and rewarmed with rewarming rates of 0.15°C/hr and 0.25°C/hr. The association of the rewarming rate with poor neurologic outcomes (cerebral performance category score, 3 to 5) was investigated.
Results
A total of 71 patients were analyzed (0.15°C/hr, n=36; 0.25°C/hr, n=35). In the comparison between 0.15°C/hr and 0.25°C/hr, the poor neurologic outcome did not significantly differ (24 [66.7%] vs. 25 [71.4%], respectively; P=0.66). In the multivariate analysis, the rewarming rate of 0.15°C/hr was not associated with the 1-month neurologic outcome improvement (odds ratio, 0.54; 95% confidence interval, 0.16 to 1.69; P=0.28).
Conclusion
The rewarming rates of 0.15°C/hr and 0.25°C/hr were not associated with the neurologic outcome difference in post cardiac arrest patients.

Citations

Citations to this article as recorded by  Crossref logo
  • Association Between Rewarming Rate and Survival and Neurologic Outcome of Accidental Hypothermia
    Chiaki Hara, Takuya Taira, Akihiko Inoue, Takeshi Nishimura, Shota Kikuta, Nobuhiro Yamamoto, Shinichi Ijuin, Shuhei Takauji, Mineji Hayakawa, Satoshi Ishihara
    Critical Care Medicine.2025; 53(7): e1416.     CrossRef
  • Temperature Control After Cardiac Arrest: A Narrative Review
    Samantha Fernandez Hernandez, Brooke Barlow, Vera Pertsovskaya, Carolina B. Maciel
    Advances in Therapy.2023; 40(5): 2097.     CrossRef
  • Rapid rewarming rate associated with favorable neurological outcomes in patients with post–cardiac arrest syndrome patients treated with targeted temperature management
    Masaru Shin, Motoki Fujita, Toru Hifumi, Yasutaka Koga, Takeshi Yagi, Takashi Nakahara, Masaki Todani, Kotaro Kaneda, Ryosuke Tsuruta
    Acute Medicine & Surgery.2023;[Epub]     CrossRef
  • Targeted Temperature Management After Cardiac Arrest
    Nicole Kupchik
    Critical Care Nursing Clinics of North America.2021; 33(3): 303.     CrossRef
  • Impact of rewarming rate on interleukin-6 levels in patients with shockable cardiac arrest receiving targeted temperature management at 33 °C: the ISOCRATE pilot randomized controlled trial
    Jean-Baptiste Lascarrou, Elie Guichard, Jean Reignier, Amélie Le Gouge, Caroline Pouplet, Stéphanie Martin, Jean-Claude Lacherade, Gwenhael Colin, M. Azais, K. Bachoumas, A. Bailly, L. Camous, G. Colin, L. Crosby, M. Fiancette, M. Henry Lagarrigue, J. C.
    Critical Care.2021;[Epub]     CrossRef
  • Rewarming: The neglected phase of targeted temperature management
    Niklas Nielsen, Hans Kirkegaard
    Resuscitation.2020; 146: 249.     CrossRef
  • High Quality Targeted Temperature Management (TTM) After Cardiac Arrest
    Fabio Silvio Taccone, Edoardo Picetti, Jean-Louis Vincent
    Critical Care.2020;[Epub]     CrossRef
  • Resuscitating the Globally Ischemic Brain: TTM and Beyond
    Melika Hosseini, Robert H. Wilson, Christian Crouzet, Arya Amirhekmat, Kevin S. Wei, Yama Akbari
    Neurotherapeutics.2020; 17(2): 539.     CrossRef
  • A practical approach to the use of targeted temperature management after cardiac arrest
    Filippo Annoni, Katia Donadello, Leda Nobile, Fabio S. Taccone
    Minerva Anestesiologica.2020;[Epub]     CrossRef
  • 15,395 View
  • 132 Download
  • 10 Web of Science
  • 9 Crossref

Case Report

Medical Emergencies

A rare case of miliary tuberculosis accompanying perihepatitis
Ou Jun Kwon, Suk Woo Lee, Mun Sun Jang, Sang Chul Kim, Ji Han Lee, Hoon Kim
Clin Exp Emerg Med 2019;6(3):264-267.   Published online February 12, 2019
DOI: https://doi.org/10.15441/ceem.18.017

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A rare case of miliary tuberculosis accompanying perihepatitis
Clin Exp Emerg Med. 2019;6(3):264-267.   Published online February 12, 2019
DOI: https://doi.org/10.15441/ceem.18.017
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A rare case of miliary tuberculosis accompanying perihepatitis
Clin Exp Emerg Med. 2019;6(3):264-267.   Published online February 12, 2019
DOI: https://doi.org/10.15441/ceem.18.017
Close
Perihepatic capsulitis is associated with various diseases, such as Fitz-Hugh-Curtis syndrome, systemic lupus erythematosus, perforated cholecystitis, perforated hepatic abscess, and tuberculous peritonitis. Miliary tuberculosis is present in about 2% of all reported cases of tuberculosis and is characterized by the widespread millet-like hematogenous dissemination of Mycobacterium tuberculosis. We describe a 24-year-old virgin patient presenting with right upper quadrant and costovertebral angle pain. Diffuse perihepatic capsular enhancement was observed in abdominal computed tomography scans. Chest radiography showed miliary tuberculosis, and a polymerase chain reaction hybridization assay of sputum revealed the presence of M. tuberculosis. Symptoms improved after administering anti-tuberculosis medications. This report describes a rare case of miliary tuberculosis accompanying perihepatitis.

Citations

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  • Diagnostic determinants of acid-fast bacilli culture positivity in miliary TB
    J. Yang, M. Choi, K.S. Yi, Y.J. Lee, E.C. Kim, G. Min, M. Kim, E. Park, J.Y. Cho, Y.M. Shin, K.H. Choe, K.M. Lee, B. Yang, S.-H. Kim
    IJTLD Open.2026; 3(4): 269.     CrossRef
  • Pneumococcal perihepatitis due to hematogeneous dissemination
    Koichiro Okumura, Yu Sato, Hiroaki Yonekura, Noriyoshi Toki, Takaie Kuki, Satoshi Watanuki, Kenji Nishida
    IDCases.2020; 21: e00856.     CrossRef
  • 26,449 View
  • 176 Download
  • 1 Web of Science
  • 2 Crossref

Original Articles

Emergency Medicine Practice and Administration

Factors associated with satisfaction with pediatric emergency department services in Korea: analysis of Korea Health Panel Data 2010 to 2012
Kyeong Jae Lee, Min Joung Kim, Joon Min Park, Kyung Hwan Kim, Junseok Park, Dong Wun Shin, Hoon Kim, Woochan Jeon, Hyunjong Kim
Clin Exp Emerg Med 2018;5(3):156-164.   Published online September 30, 2018
DOI: https://doi.org/10.15441/ceem.17.254

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Factors associated with satisfaction with pediatric emergency department services in Korea: analysis of Korea Health Panel Data 2010 to 2012
Clin Exp Emerg Med. 2018;5(3):156-164.   Published online September 30, 2018
DOI: https://doi.org/10.15441/ceem.17.254
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Factors associated with satisfaction with pediatric emergency department services in Korea: analysis of Korea Health Panel Data 2010 to 2012
Clin Exp Emerg Med. 2018;5(3):156-164.   Published online September 30, 2018
DOI: https://doi.org/10.15441/ceem.17.254
Close
Objective
We aimed to investigate the factors related to satisfaction with the pediatric emergency department service in Korea.
Methods
This study examined data from the Korea Health Panel Data from 2010 to 2012. Pediatric patients who visited the emergency department at least once between 2010 and 2012 in Korea were included. Data were collected on patient satisfaction with the emergency department service, and factors related to the patient characteristics, emergency department service process, and medical institution. We compared the dissatisfied and satisfied groups, and calculated the odds ratios for satisfaction according to each variable.
Results
A total of 1,505 emergency department visits from 947 pediatric patients during the 3-year period were analyzed. We estimated that about 79.5% of patients in the population were satisfied. The odds of expressing satisfaction were higher among males than in females, and among patients who were hospitalized after emergency department treatment compared to those who were transferred to another hospital. Conversely, the odds of expressing satisfaction were lower among patients who had a chronic disease, a financial source other than National Health Insurance, experienced hospitalization within 1 year.
Conclusion
Our study results might be helpful for establishing a satisfactory pediatric emergency medical service system. In the future, further prospective studies evaluating the causal relationships between the relevant factors and patient satisfaction are warranted.

Citations

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  • Predictors of Caregiver Satisfaction With Pediatric Laceration Repair in the Pediatric Emergency Department
    Soyun Hwang, Jin Hee Lee, Young Ho Kwak, Do Kyun Kim, Jin Hee Jung, Jae Yun Jung, Hyuksool Kwon, Dongbum Suh, Yoo Jin Choi, Se Uk Lee, Joong Wan Park
    Pediatric Emergency Care.2023; 39(5): 324.     CrossRef
  • Status and trends of medical expenditures for poisoning patients
    Eung Nam Kim, Soyoung Jeon, Hye Sun Lee, Sung Phil Chung
    Journal of The Korean Society of Clinical Toxicology.2023; 21(1): 24.     CrossRef
  • Effect of usual source of care on receiving smoking cessation advice: Korean National Health Panel data analysis
    Sollip Kim, Hye Kyeong Park, Jae Ho Lee, Hong-Jun Cho, Nak Jin Sung
    Family Practice.2021; 38(3): 218.     CrossRef
  • Customers satisfaction in pediatric inpatient services: A multiple criteria satisfaction analysis
    Diogo Cunha Ferreira, Rui Cunha Marques, Alexandre Morais Nunes, José Rui Figueira
    Socio-Economic Planning Sciences.2021; 78: 101036.     CrossRef
  • 9,687 View
  • 90 Download
  • 4 Web of Science
  • 4 Crossref

Toxicology

Therapeutic effect of ascorbic acid on dapsone-induced methemoglobinemia in rats
Changwoo Kang, Dong Hoon Kim, Taeyun Kim, Soo Hoon Lee, Jin Hee Jeong, Sang Bong Lee, Jin Hyun Kim, Myeong Hee Jung, Kyung-woo Lee, In Sung Park
Clin Exp Emerg Med 2018;5(3):192-198.   Published online September 30, 2018
DOI: https://doi.org/10.15441/ceem.17.253

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Therapeutic effect of ascorbic acid on dapsone-induced methemoglobinemia in rats
Clin Exp Emerg Med. 2018;5(3):192-198.   Published online September 30, 2018
DOI: https://doi.org/10.15441/ceem.17.253
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Therapeutic effect of ascorbic acid on dapsone-induced methemoglobinemia in rats
Clin Exp Emerg Med. 2018;5(3):192-198.   Published online September 30, 2018
DOI: https://doi.org/10.15441/ceem.17.253
Close
Objective
Dapsone (diaminodiphenyl sulfone, DDS) is currently used to treat leprosy, malaria, dermatitis herpetiformis, and other diseases. It is also used to treat pneumocystis pneumonia and Toxoplasma gondii infection in HIV-positive patients. The most common adverse effect of DDS is methemoglobinemia from oxidative stress. Ascorbic acid is an antioxidant and reducing agent that scavenges the free radicals produced by oxidative stress. The present study aimed to investigate the effect of ascorbic acid in the treatment of DDS induced methemoglobinemia.
Methods
Male Sprague-Dawley rats were divided into three groups: an ascorbic acid group, a methylene blue (MB) group, and a control group. After DDS (40 mg/kg) treatment via oral gavage, ascorbic acid (15 mg/kg), MB (1 mg/kg), or normal saline were administered via tail vein injection. Depending on the duration of the DDS treatment, blood methemoglobin levels, as well as the nitric oxide levels and catalase activity, were measured at 60, 120, or 180 minutes after DDS administration.
Results
Methemoglobin concentrations in the ascorbic acid and MB groups were significantly lower compared to those in the control group across multiple time points. The plasma nitric oxide levels and catalase activity were not different among the groups or time points.
Conclusion
Intravenous ascorbic acid administration is effective in treating DDS-induced methemoglobinemia in a murine model.

Citations

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  • Clinical Indicators Suggesting Dapsone-Induced Methemoglobinemia in Dermatology Outpatients: A Pilot Retrospective Cohort Study
    Jerene Mathews, Anju Thomas, Pooja Lekshmi S, Haritha B Meda, Febin Ashraf
    Cureus.2026;[Epub]     CrossRef
  • Congenital methaemoglobinaemia in pregnancy
    Anusha Tamma Reddy, Manisha Madhai Beck, Greeshma Grace Thomas, Nitish Vijayanand
    BMJ Case Reports.2025; 18(5): e263737.     CrossRef
  • Alpha-Lipoic Acid Reduces Methemoglobin and Oxidative Imbalance in the Blood and Liver Induced by Dapsone in Mice: Molecular Mechanism of Antioxidant Action
    Savio Monteiro dos Santos, Joni Tetsuo Sakai, Bruno Alexandre Quadros Gomes, Lisa Maria Mendes de Almeida Souza, Roseane Guimarães Ferreira, Kaio Murilo Monteiro Espíndola, Ana Flávia Oliveira Pampolha, Kelly Davis, Pamela Suelen da S. Seabra, Larissa de
    ACS Pharmacology & Translational Science.2025; 8(7): 2153.     CrossRef
  • Ascorbic Acid for Methemoglobinemia Treatment: A Case Report and Literature Review
    Kelli R Keats, Rachel Robinson, Mallika Patel, Alexis Wallace, Stephanie Albrecht
    Journal of Pharmacy Practice.2024; 37(4): 1015.     CrossRef
  • The Potential Effect of Dapsone on the Inflammatory Reactions in COVID-19: Staggering View
    Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Engy Elekhnawy, Athanasios Alexiou, Gaber El-Saber Batiha
    Combinatorial Chemistry & High Throughput Screening.2024; 27(5): 674.     CrossRef
  • Free Radical Scavenging Activity of Boron and Vitamin C in Nitrite-Induced Hemoglobin Oxidation Model: In vitro and in vivo Studies
    Hozan Jaza Hama Salh, Tavga Ahmed Aziz, Zheen Aorahman Ahmed, Dlivan Fattah Aziz
    Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ).2023; 5: 157.     CrossRef
  • Hemolytic anemia in COVID-19
    Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Ajeet Kaushik, Małgorzata Kujawska, Gaber El-Saber Batiha
    Annals of Hematology.2022; 101(9): 1887.     CrossRef
  • Methaemoglobinaemia in pregnancy: Real world experience in a single centre in Malaysia
    Andy Sing Ong Tang, Kok Choon Cheah, Tze Shin Leong, Lee Ping Chew
    Proceedings of Singapore Healthcare.2022;[Epub]     CrossRef
  • Rapid Potentiometric Determination of Ascorbic Acid Using Iodate as a Reagent
    Anita Martinović Bevanda, Antonela Matić, Stanislava Talić, Anita Ivanković, Ante Prkić, Andrea Paut, Tina Vukušić
    International Journal of Electrochemical Science.2022; 17(7): 220730.     CrossRef
  • Methemoglobinemia due to prilocaine use during jaw deformity surgery: A case report
    Naoko Tsunoda, Tadashi Kawai, Kei Onodera, Yuko Komatsu, Shuu Suzuki, Toshimi Chiba, Hiroyuki Yamada
    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2020; 32(5): 377.     CrossRef
  • Role of ascorbic acid in dapsone induced methemoglobinemia
    Kamal Kant Sahu, Ajay Kumar Mishra
    Clinical and Experimental Emergency Medicine.2019; 6(1): 91.     CrossRef
  • Methemoglobinemia: Infants at risk
    Sarah Fossen Johnson
    Current Problems in Pediatric and Adolescent Health Care.2019; 49(3): 57.     CrossRef
  • 21,025 View
  • 196 Download
  • 13 Web of Science
  • 12 Crossref
Serum markers and development of delayed neuropsychological sequelae after acute carbon monoxide poisoning: anion gap, lactate, osmolarity, S100B protein, and interleukin-6
Hyukhoon Kim, Sangchun Choi, Eunjung Park, Eunhui Yoon, Younggi Min, Samsun Lampotang
Clin Exp Emerg Med 2018;5(3):185-191.   Published online September 30, 2018
DOI: https://doi.org/10.15441/ceem.17.217

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Serum markers and development of delayed neuropsychological sequelae after acute carbon monoxide poisoning: anion gap, lactate, osmolarity, S100B protein, and interleukin-6
Clin Exp Emerg Med. 2018;5(3):185-191.   Published online September 30, 2018
DOI: https://doi.org/10.15441/ceem.17.217
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Serum markers and development of delayed neuropsychological sequelae after acute carbon monoxide poisoning: anion gap, lactate, osmolarity, S100B protein, and interleukin-6
Clin Exp Emerg Med. 2018;5(3):185-191.   Published online September 30, 2018
DOI: https://doi.org/10.15441/ceem.17.217
Close
Objective
Reliable biomarkers of delayed neuropsychological sequelae (DNS) after acute carbon monoxide (CO) poisoning are lacking. This study investigated the associations between potential serum markers and the development of DNS after acute CO poisoning.
Methods
Retrospective chart reviews were conducted for patients diagnosed with acute CO poisoning during a 28-month period. The patients were divided into two groups according to the presence or absence of having developed DNS. Multivariate analysis was performed to identify predictors of DNS after CO poisoning.
Results
Of a total of 102 patients, 10 (9.8%) developed DNS. The levels of serum osmolarity, S100B protein, and serum lactate, as well as serum anion gap, were statistically significant in univariate analysis. Multiple logistic regression analysis showed that anion gap (adjusted odds ratio [AOR], 1.36; 95% confidence interval [CI], 1.11 to 1.88), serum lactate level (AOR, 1.74; 95% CI, 1.26 to 2.75), and serum S100B protein level ([AOR, 7.02×105; 95% CI, 4.56×102 to 9.00×1010] in model 1, [AOR, 3.69×105; 95% CI, 2.49×102 to 2.71×1011] in model 2) were independently associated with DNS development.
Conclusion
Based on our preliminary results, serum lactate level, serum anion gap, and serum S100B protein level in the emergency department could be informative predictors of DNS development in patients with acute CO poisoning. These markers might have the potential to improve early recognition of DNS in patients with acute CO poisoning.

Citations

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  • Clinical characteristics and the risk factors analysis in patients with delayed encephalopathy after acute carbon monoxide poisoning
    Ziang Han, Sumeng Shi, Yan Zhang, Ding Yuan, Zhigao Xu, Yanxia Gao
    Human & Experimental Toxicology.2025;[Epub]     CrossRef
  • Optic nerve sheath diameter measurements to predict delayed neurological sequelae after carbon monoxide poisoning
    Yusuf Kenan Tekin
    Clinical Toxicology.2024; 62(2): 88.     CrossRef
  • Effectiveness of Initial Troponin I and Brain Natriuretic Peptide Levels as Biomarkers for Predicting Delayed Neuropsychiatric Sequelae in Patients with CO Poisoning: A Retrospective Multicenter Observational Study
    Myung Hyun Jung, Juncheol Lee, Jaehoon Oh, Byuk Sung Ko, Tae Ho Lim, Hyunggoo Kang, Yongil Cho, Kyung Hun Yoo, Sang Hwan Lee, Chang Hwan Sohn, Won Young Kim
    Journal of Personalized Medicine.2023; 13(6): 921.     CrossRef
  • Predicting scale of delayed neuropsychiatric sequelae in patients with acute carbon monoxide poisoning: A retrospective study
    Shijun Yang, Huichun Liu, Qifeng Peng, Jinlan Li, Qunhui Liu
    The American Journal of Emergency Medicine.2022; 52: 114.     CrossRef
  • Prognostic value of the myeloperoxidase index for early prediction of neurologic outcome in acute carbon monoxide poisoning
    Joong Seok Moon, Sung Hwa Kim, Yong Sung Cha
    Clinical and Experimental Emergency Medicine.2022; 9(3): 230.     CrossRef
  • Serum phosphate is not an early predictor of neurocognitive outcomes in acute carbon monoxide poisoning patients
    Yuseon Lee, Sung Hwa Kim, Yong Sung Cha
    Clinical and Experimental Emergency Medicine.2022; 10(1): 74.     CrossRef
  • Assessment of serum glucose/potassium ratio as a predictor for delayed neuropsychiatric syndrome of carbon monoxide poisoning
    E Demirtaş, İ Korkmaz, YK Tekin, Es Demirtaş, İ Çaltekin
    Human & Experimental Toxicology.2021; 40(2): 207.     CrossRef
  • Risk factors for delayed encephalopathy following carbon monoxide poisoning: Importance of the period of inability to walk in the acute stage
    Yasuhiro Suzuki, Benito Soto-Blanco
    PLOS ONE.2021; 16(3): e0249395.     CrossRef
  • Serum NSE and S100B protein levels for evaluating the impaired consciousness in patients with acute carbon monoxide poisoning
    Litao Zhang, Jing Zhao, Qingqing Hao, Xin Xu, Hu Han, Jianguo Li
    Medicine.2021; 100(25): e26458.     CrossRef
  • Use of hyperbaric oxygen therapy for preventing delayed neurological sequelae in patients with carbon monoxide poisoning: A multicenter, prospective, observational study in Japan
    Motoki Fujita, Masaki Todani, Kotaro Kaneda, Shinya Suzuki, Shinjiro Wakai, Shota Kikuta, Satomi Sasaki, Noriyuki Hattori, Kazuyoshi Yagishita, Koji Kuwata, Ryosuke Tsuruta, Tai-Heng Chen
    PLOS ONE.2021; 16(6): e0253602.     CrossRef
  • Incidence patterns of nervous system diseases after carbon monoxide poisoning: a retrospective longitudinal study in South Korea from 2012 to 2018
    Bangshill Rhee, Hyuk-Hoon Kim, Sangchun Choi, Young Gi Min
    Clinical and Experimental Emergency Medicine.2021; 8(2): 111.     CrossRef
  • Prediction of delayed neuropsychiatric sequelae after carbon monoxide poisoning via serial determination of serum neuron-specific enolase levels
    Sangun Nah, Sungwoo Choi, Gi Woon Kim, Ji Eun Moon, Young Hwan Lee, Sangsoo Han
    Human & Experimental Toxicology.2021; 40(12_suppl): S339.     CrossRef
  • Does alcohol play the role of confounder or neuroprotective agent in acute carbon monoxide poisoning?
    Jeong Mi Moon, Byeong Jo Chun, Yong Soo Cho, Jong Goo Mun
    Clinical Toxicology.2020; 58(3): 161.     CrossRef
  • S-100β in predicting the need of hyperbaric oxygen in CO-induced delayed neurological sequels
    Amal SAF Hafez, Ghada N El-Sarnagawy
    Human & Experimental Toxicology.2020; 39(5): 614.     CrossRef
  • Clinical and Magnetic Resonance Imaging Findings of Patients with Acute Carbon Monoxide Poisoning
    Nezih KAVAK, Burcu DOĞAN, Hasan SULTANOĞLU, Rasime Pelin KAVAK, Meltem ÖZDEMİR
    Konuralp Tıp Dergisi.2020; 12(3): 443.     CrossRef
  • Observation on promoting resuscitation in the patients with coma of acute carbon monoxide poisoning by acupuncture combined with hyperbaric oxygen
    Mao-li LUO, Hui-jie LI, Liang-ce MA, Yuan JIANG
    World Journal of Acupuncture - Moxibustion.2019; 29(2): 103.     CrossRef
  • 9,404 View
  • 132 Download
  • 21 Web of Science
  • 16 Crossref

Infectious Disease | Emergency Medical Services

Impact of Middle East respiratory syndrome outbreak on the use of emergency medical resources in febrile patients
Hyunho Jeong, Sikyoung Jeong, Juseok Oh, Seon Hee Woo, Byung Hak So, Jeong Hee Wee, Ji Hoon Kim, Ji Yong Im, Seung Pill Choi, Kyoungnam Park, Byul Nim Hee Cho, Sungyoup Hong
Clin Exp Emerg Med 2017;4(2):94-101.   Published online June 30, 2017
DOI: https://doi.org/10.15441/ceem.16.166

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Impact of Middle East respiratory syndrome outbreak on the use of emergency medical resources in febrile patients
Clin Exp Emerg Med. 2017;4(2):94-101.   Published online June 30, 2017
DOI: https://doi.org/10.15441/ceem.16.166
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Impact of Middle East respiratory syndrome outbreak on the use of emergency medical resources in febrile patients
Clin Exp Emerg Med. 2017;4(2):94-101.   Published online June 30, 2017
DOI: https://doi.org/10.15441/ceem.16.166
Close
Objective
Outbreaks of transmissible respiratory infection are suspected to have significant effects on the health of pediatric and geriatric patients. The objective was to assess the impact of the Middle East respiratory syndrome (MERS) outbreak on the use of emergency resources.
Methods
An ecologic analysis of emergency department (ED) records between September and December 2015, was performed. Data was obtained from the National Emergency Department Information System database for Korea. All demographic and diagnostic data from patients presenting with febrile symptoms as a main complaint were collected. The data were compared to the equivalent period in the three years preceding the MERS outbreak in Korea.
Results
Following the MERS outbreak, there was an increase in overall ED visits by febrile patients and the proportion of visits by febrile patients, relative to total ED attendances. This effect was more prominent in the children under five years. The duration of the chief complaint before ED arrival and the length of ED stay were significantly increased among younger pediatric patients. Decreased body temperature on arrival was observed in younger pediatric patients.
Conclusion
MERS outbreak appears to have had a significant effects on ED use by febrile patients. The use of emergency care services by pediatric patients makes them more vulnerable to an outbreak of a transmissable disease. An effective strategy to control emergency center visits by non-urgent febrile patients and provide proper medical services is urgently needed.

Citations

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Case Reports

Neurology

Non-aneurysmal and non-traumatic subarachnoid hemorrhage after attempted suicide by incomplete hanging
Tae Hu Kim, Soo Hoon Lee, Dong Hoon Kim, Seong Chun Kim, Wonyoungyong Jin, So Yeon Kim, Sang Heon Shin, Sang Bong Lee
Clin Exp Emerg Med 2017;4(1):56-59.   Published online March 30, 2017
DOI: https://doi.org/10.15441/ceem.15.115

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Non-aneurysmal and non-traumatic subarachnoid hemorrhage after attempted suicide by incomplete hanging
Clin Exp Emerg Med. 2017;4(1):56-59.   Published online March 30, 2017
DOI: https://doi.org/10.15441/ceem.15.115
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Non-aneurysmal and non-traumatic subarachnoid hemorrhage after attempted suicide by incomplete hanging
Clin Exp Emerg Med. 2017;4(1):56-59.   Published online March 30, 2017
DOI: https://doi.org/10.15441/ceem.15.115
Close
Hanging is a common method of suicide that is being reported more frequently in many countries. Several complications including injuries to the cervical spine, neck vessels, and brain can occur after attempted suicide by hanging. There are only a few reports of brain computed tomography and magnetic resonance imaging of hanging victims. The most common abnormality was diffuse cerebral edema. A subarachnoid hemorrhage is an atypical complication by suicidal hanging. We report a case of a female patient who presented to an emergency department with altered mental status after attempting suicide by incomplete hanging. The patient was diagnosed with a non-aneurysmal and non-traumatic subarachnoid hemorrhage. This case shows that spontaneous subarachnoid hemorrhage can develop due to a sudden elevation of intracranial pressure, as occurs with hanging.

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  • 159 Download
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  • 8 Crossref

Medical Emergencies

Radiographic basal ganglia abnormalities secondary to nonketotic hyperglycemia with unusual clinical features
Ju Young Choi, Joon Min Park, Kyung Hwan Kim, Jun Seok Park, Dong Wun Shin, Hoon Kim, Woo Chan Jeon, Hyun Jong Kim
Clin Exp Emerg Med 2016;3(4):252-255.   Published online December 30, 2016
DOI: https://doi.org/10.15441/ceem.15.035

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Radiographic basal ganglia abnormalities secondary to nonketotic hyperglycemia with unusual clinical features
Clin Exp Emerg Med. 2016;3(4):252-255.   Published online December 30, 2016
DOI: https://doi.org/10.15441/ceem.15.035
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Radiographic basal ganglia abnormalities secondary to nonketotic hyperglycemia with unusual clinical features
Clin Exp Emerg Med. 2016;3(4):252-255.   Published online December 30, 2016
DOI: https://doi.org/10.15441/ceem.15.035
Close
A 77-year-old woman was admitted to a local clinic for altered consciousness and presented with a suspected basal ganglion hemorrhage detected on brain computed tomography. The patient was stuporous, but her vital signs were stable. Her initial blood glucose was 607 mg/dL, and a hyperdense lesion was found in the right basal ganglion on brain computed tomography. T1-weighted magnetic resonance imaging revealed high signal intensity in the right basal ganglion. Electroencephalography showed no seizure activity. The patient was treated with a fluid infusion, and serum glucose level was controlled with insulin. The patient gradually recovered consciousness and was alert within 24 hours as serum glucose level normalized. The basal ganglion lesion caused by hyperglycemia was not accompanied by involuntary limb movement. This is the first report of a patient presenting with decreased consciousness and typical neural radiographic changes associated with nonketotic hyperglycemia but without movement abnormalities.

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  • 143 Download
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Guidelines

Resuscitation

Part 4. Post-cardiac arrest care: 2015 Korean Guidelines for Cardiopulmonary Resuscitation
Young-Min Kim, Kyu Nam Park, Seung Pill Choi, Byung Kook Lee, Kyungil Park, Jeongmin Kim, Ji Hoon Kim, Sung Phil Chung, Sung Oh Hwang
Clin Exp Emerg Med 2016;3:S27-S38.   Published online July 5, 2016
DOI: https://doi.org/10.15441/ceem.16.130

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Part 4. Post-cardiac arrest care: 2015 Korean Guidelines for Cardiopulmonary Resuscitation
Clin Exp Emerg Med. 2016;3:S27-S38.   Published online July 5, 2016
DOI: https://doi.org/10.15441/ceem.16.130
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Part 4. Post-cardiac arrest care: 2015 Korean Guidelines for Cardiopulmonary Resuscitation
Clin Exp Emerg Med. 2016;3:S27-S38.   Published online July 5, 2016
DOI: https://doi.org/10.15441/ceem.16.130
Close

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    Mehmet Ozgur Erdogan, Nihat Müjdat Hökenek, Ozgur Sogut, Abdullah Algın, Kaan Yusufoglu
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    Sang Hoon Oh, Joo Suk Oh, Hyun Ho Jung, Jungtaek Park, Ji Hoon Kim, Jeong Ho Park, Jung Hee Wee, Seong Hoon Kim, Seung Pill Choi, Kyu Nam Park
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    Junhaeng Lee, Joo Suk Oh, Jong Ho Zhu, Sungyoup Hong, Sang Hyun Park, Ji Hoon Kim, Hyungsoo Kim, Mingu Seo, Kiwook Kim, Doo Hyo Lee, Hyun Ho Jung, Jungtaek Park, Young Min Oh, Semin Choi, Kyoung Ho Choi
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    Yoon Seok Jung, Hyuk-Hoon Kim, Hee Won Yang, Sangchun Choi
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Original Articles

Emergency Medicine Practice and Administration | Patient Safety

Patients who leave the emergency department against medical advice
Choung Ah Lee, Joon Pil Cho, Sang Cheon Choi, Hyuk Hoon Kim, Ju Ok Park
Clin Exp Emerg Med 2016;3(2):88-94.   Published online June 30, 2016
DOI: https://doi.org/10.15441/ceem.15.015

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Patients who leave the emergency department against medical advice
Clin Exp Emerg Med. 2016;3(2):88-94.   Published online June 30, 2016
DOI: https://doi.org/10.15441/ceem.15.015
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Patients who leave the emergency department against medical advice
Clin Exp Emerg Med. 2016;3(2):88-94.   Published online June 30, 2016
DOI: https://doi.org/10.15441/ceem.15.015
Close
Objective
Discharge against medical advice (DAMA) from the emergency department (ED) accounts for 0.1% to 2.7% of all ED discharges. DAMA carries a risk of increased mortality and readmissions. Our aim was to investigate the general characteristics of DAMA patients and the differences between them and non-DAMA patients.
Methods
We reviewed data collected by the National Emergency Medical Center between 2010 and 2011. Subjects were categorized into 2 groups, namely, the DAMA group and the non-DAMA group. We compared these groups with respect to age, gender, trauma or non-trauma status, type of hospital, health insurance, level of consciousness on admission, and diagnosis.
Results
Of 8,000,529 patients, 222,389 (2.78%) left against medical advice. The risk factors for DAMA across all age groups were as follows: no medical insurance (odds ratio [OR], 1.993), initial response to voice (OR, 2.753) or pain (OR, 2.101), trauma admission (OR, 1.126), admission to a local emergency medical center (OR, 1.215), and increased age. A high risk of DAMA was observed among patients with immune, endocrine, psychiatric, neurological, circulatory diseases, and external causes of morbidity and mortality.
Conclusion
Although DAMA cases account for only a small percentage of hospital discharges, they are important because DAMA patients have high readmission and mortality rates. It is therefore important to understand the general characteristics and predictors of DAMA in order to improve patient outcome and minimize the economic burden on the healthcare system.

Citations

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    Theeb Ayedh Alkahtani, Asaad Shujaa
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    Danielle Abou Khater, Joelle Kalaji, Alain Tanios, Charbel Ghosn, Robert Fakhoury, Mariana Helou
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    Daniel Soroudi, Micaela Rosser, Alap U. Patel, Raymond Yin, Matthew McLaughlin, Scott L. Hansen
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    RISHU KUMAR, SANDEEP JAIN, ANOOP PURKAYASTHA
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  • 응급실 기반 중독 심층 실태조사 1차년도 결과 보고
    성우 이, 수진 김, 규종 조, 미진 이, 병학 소, 경수 김, 주현 송
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Critical Care

Awareness and knowledge of sepsis in the general Korean population: comparison with the awareness and knowledge of acute myocardial infarction and stroke
Minji Park, Kyuseok Kim, Jae Hyuk Lee, Changwoo Kang, You Hwan Jo, Dong Hoon Kim, Kyeong Won Kang, Soo Hoon Lee, Chanjong Park, Joonghee Kim, Heajin Chung, Hyunmi Park, Sujin Jang
Clin Exp Emerg Med 2014;1(1):41-48.   Published online September 30, 2014
DOI: https://doi.org/10.15441/ceem.14.014

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Awareness and knowledge of sepsis in the general Korean population: comparison with the awareness and knowledge of acute myocardial infarction and stroke
Clin Exp Emerg Med. 2014;1(1):41-48.   Published online September 30, 2014
DOI: https://doi.org/10.15441/ceem.14.014
Download Citation

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Include:
Awareness and knowledge of sepsis in the general Korean population: comparison with the awareness and knowledge of acute myocardial infarction and stroke
Clin Exp Emerg Med. 2014;1(1):41-48.   Published online September 30, 2014
DOI: https://doi.org/10.15441/ceem.14.014
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Objective

Patients with severe sepsis or septic shock require timely, aggressive management to improve their outcomes, and early presentation of patients to the hospital may also be important. Thus, public awareness about sepsis may be important for improved outcomes. However, there are no studies regarding the public awareness of sepsis in the general Korean population. Therefore, the objective of this survey was to gain insight into the public awareness of sepsis.

 Methods

Prospective paper-based and web-based surveys were issued between May and June 2013 to adults aged ≥18 years.

 Results

A total of 1,081 participants responded to the survey (394 paper-based and 687 web-based). Mean age was 38.7±11.4 years, and 541 participants (50%) were men. Of the 1,081 participants, 831 (76.9%) had heard of the term “sepsis.” Of these participants, only 295 (35%) responded correctly regarding the definition of sepsis. However, 1,019 participants (94.3%) had heard of acute myocardial infarction, and 817 of these (80%) correctly defined acute myocardial infarction. Regarding stroke, 1,047 (96.9%) had heard of stroke, and 975 of these responded (93.1%) correctly to the definition of stroke.

 Conclusion

There is poor public awareness about sepsis compared with that of acute myocardial infarction and stroke. This may limit the timely management of severe sepsis and septic shock.

Citations

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  • 18,033 View
  • 166 Download
  • 14 Web of Science
  • 14 Crossref
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CEEM : Clinical and Experimental Emergency Medicine