Objective This study aimed to compare the diagnostic performance of cardiac biomarkers and to evaluate the optimal cut-off values for echocardiographic cardiac injury prediction in patients with carbon monoxide (CO) poisoning.
Methods This retrospective observational cohort study included adult patients with acute CO poisoning. Patients who did not undergo transthoracic echocardiography, which was used to define patients with cardiac injury (ejection fraction <55%), were excluded. The area under the curve was used to evaluate diagnostic performance for cardiac injury prediction. Mann-Whitney U, chi-square, and Fisher exact tests were used to analyze data.
Results After excluding the 27 patients who did not undergo echocardiography, 114 patients were included in the study. Fifteen (13.2%) patients had cardiac injury. The area under the curve values for the B-type natriuretic peptide, creatine kinase-myocardial band, and troponin I were 0.711 (95% confidence interval [CI], 0.527–0.895; P=0.011), 0.766 (95% CI, 0.607–0.926; P=0.001), and 0.801 (95% CI, 0.647–0.955; P<0.001), respectively, with optimal cut-off values of 330 pg/mL, 10.1 ng/mL, and 0.455 ng/mL, respectively. The sensitivity, specificity, and positive and negative predictive values of troponin I were 67%, 91%, 53%, and 95%, respectively.
Conclusion Troponin I showed the best diagnostic performance for predicting cardiac injury in patients with CO poisoning. A cut-off value of 0.455 ng/mL appeared optimal for cardiac injury prediction. However, further studies on cardiac biomarkers and other diagnostic tools in CO poisoning are needed given the low sensitivity of troponin I.
Citations
Citations to this article as recorded by
Risk stratification for myocardial injury and mortality in acute carbon monoxide poisoning: a multivariable predictive model Yongai Ling, Changsheng Ye, Xianwei Xiong, Huihua Huang, Weiguang Wang Inhalation Toxicology.2026; 38(5): 268. CrossRef
Development of a risk prediction nomogram for delayed neuropsychiatric sequelae in patients with acute carbon monoxide poisoning Ghada N. El-Sarnagawy, Fatma M. Elgazzar, Mona M. Ghonem Inhalation Toxicology.2024; 36(6): 406. CrossRef
Multiplexed SERS Detection of Serum Cardiac Markers Using Plasmonic Metasurfaces Peng Zheng, Lintong Wu, Piyush Raj, Jeong Hee Kim, Santosh Kumar Paidi, Steve Semancik, Ishan Barman Advanced Science.2024;[Epub] CrossRef
The effect of full blood count and cardiac biomarkers on prognosis in carbon monoxide poisoning in children Sevcan İpek, Ufuk Utku Güllü, Şükrü Güngör, Şeyma Demiray Irish Journal of Medical Science (1971 -).2023; 192(5): 2457. CrossRef
What is New in Eurasian Journal of Emergency Medicine-Long-term Cardiac Effect of Carbon Monoxide Poisoning İsa Kılıçaslan Eurasian Journal of Emergency Medicine.2023; 22(2): 63. CrossRef
MYOGLOBIN vs. HEMOGLOBIN BLOCKADE MODEL RELATED SMOKE GAS INHALATION - A COMPUTATIONAL ANALYSIS LUCIANA TEODORA ROTARU, RENATA MARIA VARUT, FLAVIUS TRUICU, ALINA GIRNICEANU, MARIA FORTOFOIU, CRISTIAN CONSTANTIN Journal of Science and Arts.2022; 22(3): 711. CrossRef
Prediction of troponin I and N-terminal pro-brain natriuretic peptide levels in acute carbon monoxide poisoning using advanced electrocardiogram analysis, Alexandria, Egypt Manal Hassan Abdel Aziz, Fatma Mohamed Magdy Badr El Dine, Heba Abdel Samie Mohamed Hussein, Ahmed Mokhtar Abdelazeem, Israa Mahmoud Sanad Environmental Science and Pollution Research.2021; 28(35): 48754. CrossRef
First
Prev
