Central retinal artery occlusion (CRAO) is considered an ophthalmologic emergency. The prognosis of this disease is very poor. Currently, there is no generally effective therapy available to treat CRAO. Hyperbaric oxygen therapy (HBOT) can increase the volume of oxygen delivered to the ischemic retinal tissue until spontaneous or assisted reperfusion occurs. We report the case of a patient who experienced sudden visual loss due to CRAO that was treated with HBOT. The patient was an 81-year-old woman who presented with CRAO in her right eye (OD). She exhibited “hand motion” visual acuity before treatment. She underwent three sessions of HBOT at a pressure of 2.8 atmospheres absolute, performed over 3 days. After 4 days in hospital, her visual acuity improved to 0.4 (OD) for far vision and 0.5 (OD) for near vision. Her vision was stable without the supply of oxygen; therefore, she was discharged.
Citations
Citations to this article as recorded by
Hyperbaric Oxygen Therapy in Acute Retinal Ischemia (CRAO and BRAO): A Narrative Review Wiktoria Czuj-Porębska, Damian Porębski, Rafał Czuj Polish Hyperbaric Research.2026; 95(2): 101. CrossRef
The effects of hyperbaric oxygen treatment for non-arteritic central retinal artery occlusion (HBOT-CRAO) Drue M. Orwig, Jianyong Wang, Zongyuan Li, John J. McGlynn, Naser HajAissa, Alan Davis, Majesta Hovingh, Laurel Packard, Joshua S. Kooistra, Jiangyong Min The American Journal of Emergency Medicine.2025; 98: 1. CrossRef
Hyperbaric Oxygen Therapy for Branch Retinal Artery Occlusion: A Case Series Mateusz Zarzecki, Izabela Zawadzka, Blanka Mitera, Marzena Wojewódzka-Żelezniakowicz, Joanna Konopińska Cureus.2025;[Epub] CrossRef
Aetiology, Diagnosis and Treatment of Arterial Occlusions of the Retina—A Narrative Review Barbara Daxer, Wolfgang Radner, Florian Fischer, Andreea-Liliana Cocoșilă, Armin Ettl Medicina.2024; 60(4): 526. CrossRef
Addressing retinal hypoxia: pathophysiology, therapeutic innovations, and future prospects Bhargavee Gnanasambandam, Jacob Prince, Siddharth Limaye, Eric Moran, Ben Lee, Justin Huynh, Joseph Irudayaraj, Michael Tsipursky Therapeutic Advances in Ophthalmology.2024;[Epub] CrossRef
Hyperbaric Oxygen Therapy Combined with Immunosuppression for Acute Macular Neuroretinopathy in Systemic Lupus Erythematosus Daraius Shroff, Abhishek Kothari, Priyanka Gupta, Tarun Kumar Sahni, Shishir Narain Ocular Immunology and Inflammation.2023; 31(2): 355. CrossRef
Neuroprotection for Nonarteritic Central Retinal Artery Occlusion: Lessons from Acute Ischemic Stroke Ogugua Ndubuisi Okonkwo, Chineze Thelma Agweye, Toyin Akanbi Clinical Ophthalmology.2023; Volume 17: 1531. CrossRef
Novel pharmaceuticals for the management of retinal vein occlusion and linked disorders Matthew Driban, Nikita Kedia, Supriya Arora, Jay Chhablani Expert Review of Clinical Pharmacology.2023; 16(11): 1125. CrossRef
Hyperbaric Oxygen Therapy in Ophthalmology: A Narrative Review Zuzanna Micun, Weronika Dobrzyńska, Michał Sieśkiewicz, Izabela Zawadzka, Diana Anna Dmuchowska, Marzena Wojewodzka-Zelezniakowicz, Joanna Konopińska Journal of Clinical Medicine.2023; 13(1): 29. CrossRef
An old lady with acute headache and sudden blindness Sunny Chi Lik Au, Simon Tak Chuen Ko Hong Kong Journal of Emergency Medicine.2021; 28(2): 121. CrossRef
A General Overview on the Hyperbaric Oxygen Therapy: Applications, Mechanisms and Translational Opportunities Miguel A. Ortega, Oscar Fraile-Martinez, Cielo García-Montero, Enrique Callejón-Peláez, Miguel A. Sáez, Miguel A. Álvarez-Mon, Natalio García-Honduvilla, Jorge Monserrat, Melchor Álvarez-Mon, Julia Bujan, María Luisa Canals Medicina.2021; 57(9): 864. CrossRef
Authors’ reply Argyrios Chronopoulos, James S. Schutz Survey of Ophthalmology.2020; 65(1): 117. CrossRef
Hyperbaric oxygen therapy in ophthalmic practice: an expert opinion Lawrence J. Lin, Tiffany X. Chen, Kenneth J. Wald, Andrea A. Tooley, Richard D. Lisman, Ernest S. Chiu Expert Review of Ophthalmology.2020; 15(2): 119. CrossRef
Central Retinal Artery Occlusion After Nasosinal Surgery – an Insight
Somya Chowdhary, Vivek Sawhney, Abhijit Pandya, Kumar Sambhav, Shailesh K Gupta International Medical Case Reports Journal.2020; Volume 13: 211. CrossRef
Assessing the risk of stroke development following retinal artery occlusion Ibraheem S. Shaikh, Samer T. Elsamna, Marco A. Zarbin, Neelakshi Bhagat Journal of Stroke and Cerebrovascular Diseases.2020; 29(9): 105002. CrossRef
Authors' response Argyrios Chronopoulos, James S. Schutz Survey of Ophthalmology.2019; 64(4): 591. CrossRef
Objective In severe organophosphate (OP) poisoning, administration of atropine via continuous intravenous infusion is typically considered. To date, there have been no studies on predicting successful atropine discontinuation through plasma cholinesterase (PChE) and serum lactate levels, which are monitored during critical care in severe acute OP poisoning. Therefore, we retrospectively evaluated the usefulness of serum lactate and PChE as predictors of successful discontinuation of atropine infusion.
Methods This retrospective observational study was performed on consecutive adult patients treated for severe acute OP poisoning between March 2011 and December 2016. We sequentially evaluated serum lactate and PChE levels on emergency department arrival and before a discontinuation trial of atropine infusion. Discontinuation of atropine intravenous infusion was attempted in patients after clearance of respiratory secretions and cessation of bronchoconstriction. Discontinuation of atropine infusion attempts were divided into successful and failed trials.
Results A total of 95 trials were conducted in 62 patients. Serum lactate levels before trials were significantly different between patients with successful and failed trials. The area under the curve for prediction of successful atropine discontinuation using serum lactate levels before trial discontinuation were 0.742 (95% confidence interval, 0.638 to 0.846). PChE level was not significantly different between two groups.
Conclusion Serum lactate levels before the discontinuation trial of atropine infusion served to predict successful discontinuation in severe acute OP poisoning.
Citations
Citations to this article as recorded by
Early Markers in Severe Organophosphorus Poisoning and Their Association with Mortality Ashaq Hussain Parrey, Manzoor Koka, Mohd. Ismail, Mohd. Ashraf, Hyder Lone The Journal of Emergency Medicine.2025; 73: 95. CrossRef
Atropine sulfate as a continuous intravenous infusion for the treatment of organophosphate toxicity in a cat Edward Baker, Carl Southern, Jennifer Martinez Journal of Feline Medicine and Surgery Open Reports.2024;[Epub] CrossRef
Organophosphate Poisoning in a Paediatric Intensive Care Unit: A Retrospective Analysis Based on Ten Years of Experience Abdullah Yousef, Waleed Albuali, Mohammed AlOmari, Abdullah AlMutairi, Hamad W Albuali, Faisal O AlQurashi, Hassan M Alshaqaq International Journal of General Medicine.2022; Volume 15: 6269. CrossRef
A Rare Presentation of Severe Organophosphate Poisoning: A Case Report and Review of Literature Anastasia E Ibrahim, Henrik Ghantarchyan, Thucminh Le, Ankur Bhagat, Bahareh Maknouni, Sarkis Arabian Cureus.2022;[Epub] CrossRef
First
Prev
