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"Intoxication"

Original Article

Toxicology | Psychosocial

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Predictors of intentional intoxication using decision tree modeling analysis: a retrospective study
Clin Exp Emerg Med. 2018;5(4):230-239.   Published online December 31, 2018
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Predictors of intentional intoxication using decision tree modeling analysis: a retrospective study
Clin Exp Emerg Med. 2018;5(4):230-239.   Published online December 31, 2018
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Objective
The suicide rate in South Korea is very high and is expected to increase in coming years. Intoxication is the most common suicide attempt method as well as one of the common reason for presenting to an emergency medical center. We used decision tree modeling analysis to identify predictors of risk for suicide by intentional intoxication.
Methods
A single-center, retrospective study was conducted at our hospital using a 4-year registry of the institute from January 1, 2013 to December 31, 2016. Demographic factors, such as sex, age, intentionality, therapeutic adherence, alcohol consumption, smoking status, physical disease, cancer, psychiatric disease, and toxicological factors, such as type of intoxicant and poisoning severity score were collected. Candidate risk factors based on the decision tree were used to select variables for multiple logistic regression analysis.
Results
In total, 4,023 patients with intoxication were enrolled as study participants, with 2,247 (55.9%) identified as cases of intentional intoxication. Reported annual percentages of intentional intoxication among patients were 628/937 (67.0%), 608/1,082 (56.2%), 536/1,017 (52.7), 475/987 (48.1%) from 2013 to 2016. Significant predictors identified based on decision tree analysis were alcohol consumption, old age, psychiatric disease, smoking, and male sex; those identified based on multiple regression analysis were alcohol consumption, smoking, male sex, psychiatric disease, old age, poor therapeutic adherence, and physical disease.
Conclusion
We identified important predictors of suicide risk by intentional intoxication. A specific and realistic approach to analysis using the decision tree modeling technique is an effective method to determine those groups at risk of suicide by intentional intoxication.

Citations

Citations to this article as recorded by  Crossref logo
  • Decision tree algorithm can determine the outcome of repeated supratherapeutic ingestion (RSTI) exposure to acetaminophen: review of 4500 national poison data system cases
    Omid Mehrpour, Christopher Hoyte, Foster Goss, Farshad M. Shirazi, Samaneh Nakhaee
    Drug and Chemical Toxicology.2023; 46(4): 692.     CrossRef
  • Comparison of machine learning algorithms to predict intentional and unintentional poisoning risk factors
    Yousef Veisani, Hojjat Sayyadi, Ali Sahebi, Ghobad Moradi, Fathola Mohamadian, Ali Delpisheh
    Heliyon.2023; 9(6): e17337.     CrossRef
  • Decision tree outcome prediction of acute acetaminophen exposure in the United States: A study of 30,000 cases from the National Poison Data System
    Omid Mehrpour, Farhad Saeedi, Christopher Hoyte
    Basic & Clinical Pharmacology & Toxicology.2022; 130(1): 191.     CrossRef
  • Perfil toxicológico dos suicídios no Rio Grande do Sul, Brasil, 2017 a 2019
    Maria Cristina Franck, Maristela Goldnadel Monteiro, Renata Pereira Limberger
    Revista Panamericana de Salud Pública.2021; 28: 1.     CrossRef
  • Perfil toxicológico dos suicídios no Rio Grande do Sul, Brasil, 2017 a 2019
    Maria Cristina Franck, Maristela Goldnadel Monteiro, Renata Pereira Limberger
    Revista Panamericana de Salud Pública.2021; 45: 1.     CrossRef
  • 8,336 View
  • 121 Download
  • 6 Web of Science
  • 5 Crossref

Case Report

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Monomorphic ventricular tachycardia due to protease inhibitor intoxication by atazanavir
Clin Exp Emerg Med. 2018;5(2):131-134.   Published online April 30, 2018
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Monomorphic ventricular tachycardia due to protease inhibitor intoxication by atazanavir
Clin Exp Emerg Med. 2018;5(2):131-134.   Published online April 30, 2018
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Atazanavir is a protease inhibitor approved for use in combination with other antiretroviral drugs for the treatment of human immunodeficiency virus infection. Atazanavir and other protease inhibitors can sometimes induce corrected QT prolongation and ventricular arrhythmia. A 40-year-old man with no comorbidities, except human immunodeficiency virus 1 infection, presented with palpitations 3 days after an overdose of 150 caps of atazanavir, with suicidal intent. His initial electrocardiogram showed monomorphic ventricular tachycardia, and hyperbilirubinemia was observed in his initial blood test. Immediately after magnesium sulfate infusion, his ventricular tachycardia was converted into junctional bradycardia with prolonged corrected QT. After 3 days of close observation in the intensive care unit, the corrected QT prolongation and hyperbilirubinemia were normalized.
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Original Article

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Clinical outcomes of adverse cardiovascular events in patients with acute dapsone poisoning
Clin Exp Emerg Med. 2016;3(1):41-45.   Published online March 31, 2016
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Clinical outcomes of adverse cardiovascular events in patients with acute dapsone poisoning
Clin Exp Emerg Med. 2016;3(1):41-45.   Published online March 31, 2016
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Objective
Adverse cardiovascular events (ACVEs) account for a large proportion of the morbidities and mortalities associated with drug overdose emergencies. However, there are no published reports regarding outcomes of ACVEs associated with acute dapsone poisoning. Here, the authors retrospectively analyzed ACVEs reported within 48 hours of treatment in patients with acute dapsone poisoning and assessed the significance of ACVEs as early predictors of mortality.
Methods
Sixty-one consecutive cases of acute dapsone poisoning that were diagnosed and treated at a regional emergency center between 2006 and 2014 were included in the study. An ACVE was defined as myocardial injury, shock, ventricular dysrhythmia, cardiac arrest, or any combination of these occurring within the first 48 hours of treatment for acute dapsone poisoning.
Results
Nineteen patients (31.1%) had evidence of myocardial injury (elevation of serum troponin-I level or electrocardiography signs of ischemia) after dapsone overdose, and there were a total of 19 ACVEs (31.1%), including one case of shock (1.6%). Fourteen patients (23.0%) died from pneumonia or multiple organ failure, and the incidence of ACVEs was significantly higher among non-survivors than among survivors (64.3% vs. 21.3%, P=0.006). ACVE was a significant predictor of mortality (odds ratio, 5.690; 95% confidence interval, 1.428 to 22.675; P=0.014).
Conclusion
The incidence of ACVE was significantly higher among patients who died after acute dapsone poisoning. ACVE is a significant predictor of mortality after dapsone overdose, and evidence of ACVE should be carefully sought in these patients.

Citations

Citations to this article as recorded by  Crossref logo
  • Management of Bullous Pemphigoid in Special Populations: A Narrative Review of the Literature
    Giulia Gasparini, Roberto Russo, Laura Calabrese, Martina D’Onghia, Giovanni Di Zenzo, Dario Didona, Martina Merli, Pietro Quaglino, Roberto Maglie, Emiliano Antiga, Marzia Caproni, Clara De Simone, Luisa Boeti, Gianluca Avallone, Luca Valtellini, Angelo
    Dermatologic Therapy.2025;[Epub]     CrossRef
  • Development of a risk-prediction nomogram for in-hospital adverse cardiovascular events in acute cardiotoxic agents poisoning
    Heba I. Lashin, Fatma M. Elgazzar, Sara I. El sharkawy, Sally M. Elsawaf, Zahraa Khalifa Sobh
    Toxicology Reports.2024; 13: 101826.     CrossRef
  • Dapsone for the treatment of acne vulgaris: do the risks outweigh the benefits?
    Selami Aykut Temiz, Munise Daye
    Cutaneous and Ocular Toxicology.2022; 41(1): 60.     CrossRef
  • Specific Treatment Exists for SARS-CoV-2 ARDS
    Badar Kanwar, Chul Joong Lee, Jong-Hoon Lee
    Vaccines.2021; 9(6): 635.     CrossRef
  • The Neuroinflammasome in Alzheimer’s Disease and Cerebral Stroke
    Jong-hoon Lee, Chul Joong Lee, Jungwuk Park, So Jeong Lee, Su-hee Choi
    Dementia and Geriatric Cognitive Disorders Extra.2021; 11(2): 159.     CrossRef
  • A Bitter Taste in Your Heart
    Conor J. Bloxham, Simon R. Foster, Walter G. Thomas
    Frontiers in Physiology.2020;[Epub]     CrossRef
  • 4,4′-Diaminodiphenyl Sulfone (DDS) as an Inflammasome Competitor
    Jong-hoon Lee, Ha Kyeu An, Mun-Gi Sohn, Paul Kivela, Sangsuk Oh
    International Journal of Molecular Sciences.2020; 21(17): 5953.     CrossRef
  • The usefulness of the SOFA and APACHE II scoring systems for the early prediction of mortality in patients with dapsone poisoning
    Y Lee, SJ Kim, YS Kim, H Kim, DK Lee, J Lee, TH Go, YS Cha
    Human & Experimental Toxicology.2019; 38(3): 280.     CrossRef
  • Analysis of Patients with Acute Toxic Exposure between 2009 and 2013: Data from the Korea Health Insurance Review and Assessment Service and the National Emergency Department Information System
    Young-Hoon Yoon, Jung-Youn Kim, Sung-Hyuk Choi
    Journal of Korean Medical Science.2018;[Epub]     CrossRef
  • Therapeutic effect of ascorbic acid on dapsone-induced methemoglobinemia in rats
    Changwoo Kang, Dong Hoon Kim, Taeyun Kim, Soo Hoon Lee, Jin Hee Jeong, Sang Bong Lee, Jin Hyun Kim, Myeong Hee Jung, Kyung-woo Lee, In Sung Park
    Clinical and Experimental Emergency Medicine.2018; 5(3): 192.     CrossRef
  • Dapsone overdose

    Reactions Weekly.2016; 1629(1): 99.     CrossRef
  • 13,182 View
  • 144 Download
  • 9 Web of Science
  • 11 Crossref
Case Report

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A case of survival after chlorfenapyr intoxication with acute pancreatitis
Clin Exp Emerg Med. 2015;2(1):63-66.   Published online March 31, 2015
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A case of survival after chlorfenapyr intoxication with acute pancreatitis
Clin Exp Emerg Med. 2015;2(1):63-66.   Published online March 31, 2015
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Chlorfenapyr is a moderately hazardous insecticide. There have been previous reports of chlorfenapyr intoxication, but none have reported patient survival or an association with pancreatitis. A 61-year-old woman was brought to the emergency department with vomiting after ingesting 10 mL chlorfenapyr in a suicide attempt 1 hour before. The patient was treated with gastric lavage and activated charcoal, then transferred to the intensive care unit. Initial laboratory data were unremarkable except for elevated amylase/lipase levels (134/222 U/L), which were even higher 7 days later and remained elevated for 2 weeks. Abdominal computed tomography showed diffuse pancreatic swelling. The patient improved with conservative care and was discharged to home 19 days after admission. This is the first reported case of survival after chlorfenapyr intoxication. We recommend early aggressive management in the emergency department and close monitoring in the intensive care unit to detect and treat potentially fatal deterioration after chlorfenapyr intoxication.

Citations

Citations to this article as recorded by  Crossref logo
  • Cooling-Seeking Behavior and Hot Sensation as Hallmark Toxidromes in Chlorfenapyr Intoxication: A Case Report
    Jiun-Hao Yu, Chih-Huang Hsieh, Chi-Syuan Pan, Han-Wei Mu
    The Journal of Emergency Medicine.2026; 80: 60.     CrossRef
  • Suspected chlorfenapyr poisoning in a horse
    B.P. Simões, F.M. Cerri, R.K. Takahira, A.S. Borges, J.P. Oliveira-Filho, R.M. Amorim
    Journal of Equine Veterinary Science.2025; 146: 105380.     CrossRef
  • Toxicological Review of an Uncoupler, Chlorfenapyr
    Sun Cheun Kim
    Korean Journal of Legal Medicine.2025; 49(2): 35.     CrossRef
  • Chlorfenapyr alert in Egypt: an urgent call for action to save lives!
    Asmaa Fady Sharif, Zahraa Khalifa Sobh
    Egyptian Journal of Forensic Sciences.2025;[Epub]     CrossRef
  • Delayed death of a child from chlorfenapyr poisoning: A case report and literature review
    Yishan Zhan, Jing Li, Yourong Zhu, Qiang Tao, Shouhua Zhang
    Clinical Case Reports.2024;[Epub]     CrossRef
  • Chlorfenapyr poisoning: mechanisms, clinical presentations, and treatment strategies
    Ji Cheng, Yulu Chen, Weidong Wang, Xueqi Zhu, Zhenluo Jiang, Peng Liu, Liwen Du
    World Journal of Emergency Medicine.2024; 15(3): 214.     CrossRef
  • Chlorfenapyr poisoning: a systematic review
    Grant Thomas Comstock, HoanVu Nguyen, Alvin Bronstein, Luke Yip
    Clinical Toxicology.2024; 62(7): 412.     CrossRef
  • A clinical warning in the treatment of chlorfenapyr poisoning
    Yuelei Cheng, Yunlai Zhao, Hao Li, Minmin Duan, Lianxiang Li, Song Zhou, Qingbin Tang, Wei Xie, Jixue Shi
    Toxicology Reports.2024; 13: 101703.     CrossRef
  • Emamectin·chlorfenapyr-induced fatal leukoencephalomyelopathy with delayed hyperthermia: insecticide endanger public safety
    Xun Li, Yun Yang, Yajing Zhang, Xuebin Zhang, Na Zhao, Wei Yue
    Frontiers in Neurology.2024;[Epub]     CrossRef
  • A narrative review of contemporary lethal pesticides: unveiling the ongoing threat of pesticide poisoning
    Sangchun Choi, Gi Woon Kim, Hoon Lim
    Clinical and Experimental Emergency Medicine.2024; 11(4): 335.     CrossRef
  • Experience in the treatment of chlorfenapyr poisoning
    Benhe Wu, Fei Xue, Mingfeng Lu, Aiwen Ma, Lu Fan
    The Journal of Toxicological Sciences.2023; 48(4): 221.     CrossRef
  • A Comprehensive Review of the Current Knowledge of Chlorfenapyr: Synthesis, Mode of Action, Resistance, and Environmental Toxicology
    Ping Huang, Xiyue Yan, Bo Yu, Xuan He, Lidan Lu, Yuanhang Ren
    Molecules.2023; 28(22): 7673.     CrossRef
  • A fatal case of chlorfenapyr poisoning and a review of the literature
    Shih-Chun Chien, Shih-Chao Chien, Yu-Jang Su
    Journal of International Medical Research.2022;[Epub]     CrossRef
  • A Fatal Case of Chlorfenapyr Poisoning and the Therapeutic Implications of Serum Chlorfenapyr and Tralopyril Levels
    Ming-Jin Chung, Yan-Chiao Mao, Chia-Tien Hsu, Mu-Chi Chung, Tsai-Jung Wang, Tung-Min Yu, Po-Yu Liu, Pin-Kuei Fu, Chia-Ming Hsieh
    Medicina.2022; 58(11): 1630.     CrossRef
  • 剖検にて頸胸髄の融解壊死を認めたクロルフェナピル中毒の1例(Chlorfenapyr poisoning with liquefactive necrosis of the cervical and thoracic cord: an autopsy case report)
    小橋 大輔 (Daisuke Kobashi), 堀口 真仁 (Masahito Horiguchi), 中村 光伸 (Mitsunobu Nakamura)
    Nihon Kyukyu Igakukai Zasshi: Journal of Japanese Association for Acute Medicine.2020; 31(8): 287.     CrossRef
  • A fatal case of chlorfenapyr poisoning following dermal exposure
    Sang-Kyoon Han, Seok-Ran Yeom, Sung-Hwa Lee, Soon-Chang Park, Hyung-Bin Kim, Young-Mo Cho, Sung-Wook Park
    Hong Kong Journal of Emergency Medicine.2019; 26(6): 375.     CrossRef
  • Acute chlorfenapyr toxicity in 3 dogs from a single household
    Rachel B. Davy, Samantha Campos, Alex M. Lynch
    Journal of Veterinary Emergency and Critical Care.2019; 29(6): 686.     CrossRef
  • Delayed hyperthermia from chlorfenapyr overdose
    James Chomin, William Heuser, Joshua Nogar, Mityanand Ramnarine, Richard Stripp, Payal Sud
    The American Journal of Emergency Medicine.2018;[Epub]     CrossRef
  • Chlorfenapyr Intoxication Manifested by Extensive Leukoencephalomyelopathy
    Il Soo Kim, Jae Hwan Kim, Jung Bin Kim, Ji Hyun Kim
    Journal of the Korean Neurological Association.2018; 36(4): 390.     CrossRef
  • Toxic Optic Neuropathy Caused by Chlorfenapyr Poisoning
    Su Jin Park, Jae Uk Jung, Yong Koo Kang, Bo Young Chun, Byeong Jae Son
    Journal of the Korean Ophthalmological Society.2018; 59(11): 1097.     CrossRef
  • Chlorfenapyr-Induced Toxic Leukoencephalopathy with Radiologic Reversibility: A Case Report and Literature Review
    Byung Hyun Baek, Seul Kee Kim, Woong Yoon, Tae Wook Heo, Yun Young Lee, Heoung Keun Kang
    Korean Journal of Radiology.2016; 17(2): 277.     CrossRef
  • 16,308 View
  • 132 Download
  • 18 Web of Science
  • 21 Crossref